Adriano Senatore

faculty_img Academic Title: Assistant Professor

Campus: UTM

CSB Appointment: Full

Primary Undergraduate Department:
Biology

Graduate Programs:
Cell & Systems Biology

Titles and Honors:

Academic or Administrative Appointments:

Education:
Ph.D. University of Waterloo 2012
M.Sc. University of Guelph 2006

 

Mailing Address
Department of Biology
University of Toronto
3359 Mississauga Road
Mississauga, ON L5L 1C6
Canada

 

Contact Information
Office phone:
Office: DV 3033
Lab:
Lab phone:
Email: adriano.senatore@utoronto.ca
URL: http://www.utm.utoronto.ca/biology/people/senatore-adriano

 

Research Areas
Animal Biology
Bioinformatics & Computational Biology

Cell Biology
Evolutionary Biology
Functional Genomics
Neurobiology
Physiology
Proteomics

 

Research

We seek to understand the function and dysfunction of several ion channels that play important roles in the nervous system, and further, how these and other electrogenic genes were adapted during nervous system evolution for complex cellular coordination and animal behavior. Through a broad phylogenetic approach, we explore the functional and physiological properties of:
1) Voltage-gated calcium channels that drive muscle contraction and neurotransmitter release.
2) Peptide and acid-gated ion channels (i.e. DEG/ENaC) involved in pain signaling, learning and memory, and synaptic transmission.
3) The sodium leak channel NALCN, involved in circadian rhythm, neural excitability, and sensitivity to anesthetics.
Researchers in the lab integrate a broad range of techniques using several animal model systems, including behavioral analysis, microscopy, molecular biology, electrophysiology, cell culture, proteomics, genomics/transcriptomics and bioinformatics.

 

Publications

2018

Top

Single neuron serotonin receptor subtype gene expression correlates with behavior within and across three molluscan species. Tamvacakis AN, Senatore A, Katz PS. Proc Biol Sci. 2018 Aug 22;285(1885). pii: 20180791. doi: 10.1098/rspb.2018.0791.
pubmed
Chemoreceptor proteins in the Caribbean spiny lobster, Panulirus argus: Expression of Ionotropic Receptors, Gustatory Receptors, and TRP channels in two chemosensory organs and brain. Kozma MT, Schmidt M, Ngo-Vu H, Sparks SD, Senatore A, Derby CD. PLoS One. 2018 Sep 21;13(9):e0203935. doi: 10.1371/journal.pone.0203935. eCollection 2018.
pubmed
Sequences of Circadian Clock Proteins in the Nudibranch Molluscs Hermissenda crassicornis, Melibe leonina, and Tritonia diomedea. Cook GM, Gruen AE, Morris J, Pankey MS, Senatore A, Katz PS, Watson WH 3rd, Newcomb JM. Biol Bull. 2018 Jun;234(3):207-218. doi: 10.1086/698467. Epub 2018 Jun 5.
pubmed

2017

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Neuropeptidergic integration of behavior in Trichoplax adhaerens, an animal without synapses. Senatore A, Reese TS, Smith CL. J Exp Biol. 2017 Sep 15;220(Pt 18):3381-3390. doi: 10.1242/jeb.162396.
pubmed
Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue. Smith CL, Abdallah S, Wong YY, Le P, Harracksingh AN, Artinian L, Tamvacakis AN, Rehder V, Reese TS, Senatore A. J Gen Physiol. 2017 Apr 3;149(4):483-510. doi: 10.1085/jgp.201611683. Epub 2017 Mar 22.
pubmed

2016

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Physiology and Evolution of Voltage-Gated Calcium Channels in Early Diverging Animal Phyla: Cnidaria, Placozoa, Porifera and Ctenophora. Senatore A, Raiss H, Le P. Front Physiol. 2016 Nov 4;7:481. eCollection 2016.
pubmed

2015

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Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis.Tamvacakis AN, Senatore A, Katz PS. Learn. Mem. 2015 Dec;22(12):617-21
pubmed
Deep mRNA sequencing of the Tritonia diomedea brain transcriptome provides access to gene homologues for neuronal excitability, synaptic transmission and peptidergic signalling.Senatore A, Edirisinghe N, Katz PS. PLoS ONE 2015;10(2):e0118321
pubmed

2014

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Gd3+ and calcium sensitive, sodium leak currents are features of weak membrane-glass seals in patch clamp recordings.Boone AN, Senatore A, Chemin J, Monteil A, Spafford JD. PLoS ONE 2014;9(6):e98808
pubmed
T-type channels become highly permeable to sodium ions using an alternative extracellular turret region (S5-P) outside the selectivity filter.Senatore A, Guan W, Boone AN, Spafford JD. J. Biol. Chem. 2014 Apr;289(17):11952-69
pubmed
Cav3 T-type channels: regulators for gating, membrane expression, and cation selectivity.Senatore A, Guan W, Spafford JD. Pflugers Arch. 2014 Apr;466(4):645-60
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2013

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A uniquely adaptable pore is consistent with NALCN being an ion sensor.Senatore A, Spafford JD. Channels (Austin) 2013 Mar-Apr;7(2):60-8
pubmed
NALCN ion channels have alternative selectivity filters resembling calcium channels or sodium channels.Senatore A, Monteil A, van Minnen J, Smit AB, Spafford JD. PLoS ONE 2013;8(1):e55088
pubmed
Induction of a ricinosomal-protease and programmed cell death in tomato endosperm by gibberellic acid.Trobacher CP, Senatore A, Holley C, Greenwood JS. Planta 2013 Mar;237(3):665-79
pubmed

2012

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Gene transcription and splicing of T-type channels are evolutionarily-conserved strategies for regulating channel expression and gating.Senatore A, Spafford JD. PLoS ONE 2012;7(6):e37409
pubmed

2011

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Mapping of dihydropyridine binding residues in a less sensitive invertebrate L-type calcium channel (LCa v 1).Senatore A, Boone A, Lam S, Dawson TF, Zhorov B, Spafford JD. Channels (Austin) 2011 Mar-Apr;5(2):173-87
pubmed
Optimized transfection strategy for expression and electrophysiological recording of recombinant voltage-gated ion channels in HEK-293T cells.Senatore A, Boone AN, Spafford JD. J Vis Exp 2011;(47)
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2010

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G-proteins modulate invertebrate synaptic calcium channel (LCav2) differently from the classical voltage-dependent regulation of mammalian Cav2.1 and Cav2.2 channels.Huang X, Senatore A, Dawson TF, Quan Q, Spafford JD. J. Exp. Biol. 2010 Jun;213(Pt 12):2094-103
pubmed
Transient and big are key features of an invertebrate T-type channel (LCav3) from the central nervous system of Lymnaea stagnalis.Senatore A, Spafford JD. J. Biol. Chem. 2010 Mar;285(10):7447-58
pubmed

2009

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Ricinosomes predict programmed cell death leading to anther dehiscence in tomato.Senatore A, Trobacher CP, Greenwood JS. Plant Physiol. 2009 Feb;149(2):775-90
pubmed

2008

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PKC-induced intracellular trafficking of Ca(V)2 precedes its rapid recruitment to the plasma membrane.Zhang Y, Helm JS, Senatore A, Spafford JD, Kaczmarek LK, Jonas EA. J. Neurosci. 2008 Mar;28(10):2601-12
pubmed

 

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