Andreas Hilfinger

faculty_img Academic Title: Assistant Professor

Campus: Mississauga

CSB Appointment: Cross Appointment

Primary Undergraduate Department: Department of Chemical and Physical Sciences

Graduate Programs:
Chemical and Physical Sciences
Cell and Systems Biology

Academic or Administrative Appointments

Education:
PhD Max-Planck-Institute for the Physics of Complex Systems 2006
MASt Cambridge University 2002
MSci Imperial College London 2001

Mailing Address
3359 Mississauga Rd North,
Mississauga, Ontario,
L5L 1C6.

 

Contact Information
Office phone: 905-569-4582
Office: DV4050
Lab phone:
Email: andreas.hilfinger@utoronto.ca
URL: https://hilfinger.group

 

Research Areas

Quantitative Biology
Systems Biology
Bioinformatics & Computational Biology

 

Research

All biological cells make decisions by adjusting concentrations of biochemical molecules. Because molecular levels in cells are discrete and often low, the probabilistic nature of individual chemical reactions significantly randomizes every cellular process. This non-genetic variability plays an important role in many different processes ranging from stem cell differentiation, to anti-tumor drug responses, and even DNA repair. The goal of our research is twofold. By analyzing models that describe molecular fluctuations in cells we want to understand the principles of how stochastic fluctuations are generated, transmitted, and eliminated within cellular processes. Secondly, we are developing mathematical tools to non-perturbatively identify biochemical reaction rates from single-cell fluctuation data.

 

Publications

 

 

2016

Top

Exploiting Natural Fluctuations to Identify Kinetic Mechanisms in Sparsely Characterized Systems. Hilfinger A, Norman TM, Paulsson J. Cell Syst. 2016 Apr 27;2(4):251-9. doi: 10.1016/j.cels.2016.04.002. Epub 2016 Apr 27.
pubmed
Constraints on Fluctuations in Sparsely Characterized Biological Systems. Hilfinger A, Norman TM, Vinnicombe G, Paulsson J. Phys Rev Lett. 2016 Feb 5;116(5):058101. doi: 10.1103/PhysRevLett.116.058101. Epub 2016 Feb 1.
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2015

Top

Systems biology: Defiant daughters and coordinated cousins. Hilfinger A, Paulsson J. Nature. 2015 Mar 26;519(7544):422-3. doi: 10.1038/nature14210. Epub 2015 Mar 11.pubmed
 

2012

Top

Using temporal correlations and full distributions to separate intrinsic and extrinsic fluctuations in biological systems. Hilfinger A, Chen M, Paulsson J. Phys Rev Lett. 2012 Dec 14;109(24):248104. Epub 2012 Dec 10.
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2011

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Separating intrinsic from extrinsic fluctuations in dynamic biological systems. Hilfinger A, Paulsson J. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12167-72. doi: 10.1073/pnas.1018832108. Epub 2011 Jul 5.
pubmed
 

2009

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Nonlinear dynamics of cilia and flagella. Hilfinger A, Chattopadhyay AK, Jülicher F. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 May;79(5 Pt 1):051918. Epub 2009 May 21.
pubmed
 

2008

Top

The chirality of ciliary beats. Hilfinger A, Jülicher F. Phys Biol. 2008 Mar 19;5(1):016003. doi: 10.1088/1478-3975/5/1/016003.
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