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Phytopathogen type III effectors as probes of biological systems.

Lee AH, Middleton MA, Guttman DS, Desveaux D Microb Biotechnol 2013 May; 6(3):230-40 PMID: 23433088 Abstract Bacterial phytopathogens utilize a myriad of virulence factors to modulate their plant hosts in order to promote successful pathogenesis. One potent virulence strategy is to inject these virulence proteins into plant cells via the type III secretion system. Characterizing … Read More

The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a.

Lewis JD, Lee AH, Hassan JA, Wan J, Hurley B, Jhingree JR, Wang PW, Lo T, Youn JY, Guttman DS, Desveaux D Proc. Natl. Acad. Sci. U.S.A. 2013 Nov 12; 110(46):18722-7 PMID: 24170858 Abstract Plant and animal pathogenic bacteria can suppress host immunity by injecting type III secreted effector (T3SE) proteins into host cells. However, … Read More

Proteomics of effector-triggered immunity (ETI) in plants.

Hurley B, Subramaniam R, Guttman DS, Desveaux D Virulence 2014; 5(7):752-60 PMID: 25513776 Abstract Effector-triggered immunity (ETI) was originally termed gene-for-gene resistance and dates back to fundamental observations of flax resistance to rust fungi by Harold Henry Flor in the 1940s. Since then, genetic and biochemical approaches have defined our current understanding of how plant … Read More