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Mitochondrial matrix pH acidifies during anoxia and is maintained by the FF-ATPase in anoxia-tolerant painted turtle cortical neurons.

Hawrysh PJ, Buck LT FEBS Open Bio 2019 Apr; 9(4):571-581 PMID: 30984533 Abstract The western painted turtle (Chrysemys picta bellii) can survive extended periods of anoxia via a series of mechanisms that serve to reduce its energetic needs. Central to these mechanisms is the response of mitochondria, which depolarize in response to anoxia in turtle … Read More

Taurine activates glycine and GABA receptor currents in anoxia-tolerant painted turtle pyramidal neurons.

Miles AR, Hawrysh PJ, Hossein-Javaheri N, Buck LT J. Exp. Biol. 2018 Nov 05; 221(Pt 21): PMID: 30237241 Abstract Unlike anoxia-intolerant mammals, painted turtles can survive extended periods without oxygen. This is partly accomplished by an anoxia-mediated increase in gamma-aminobutyric acid (GABA) release, which activates GABA receptors and mediates spike arrest in turtle neurons via … Read More

Synthetic Genetic Interaction (CRISPR-SGI) Profiling in .

Calarco JA, Norris AD Bio Protoc 2018 Mar 05; 8(5): PMID: 29552597 Abstract Genetic interaction screens are a powerful methodology to establish novel roles for genes and elucidate functional connections between genes. Such studies have been performed to great effect in single-cell organisms such as yeast and (Schuldiner ., 2005; Butland ., 2008; Costanzo ., … Read More