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Advanced In vivo Use of CRISPR/Cas9 and Anti-sense DNA Inhibition for Gene Manipulation in the Brain

Walters BJ, Azam AB, Gillon CJ, Josselyn SA, Zovkic IB Front Genet 2015;6:362 PMID: 26793235 Abstract Gene editing tools are essential for uncovering how genes mediate normal brain-behavior relationships and contribute to neurodegenerative and neuropsychiatric disorders. Recent progress in gene editing technology now allows neuroscientists unprecedented access to edit the genome efficiently. Although many important … Read More

RXR/USP and EcR are critical for the regulation of reproduction and the control of JH biosynthesis in Diploptera punctata

Hult EF, Huang J, Marchal E, Lam J, Tobe SS J. Insect Physiol. 2015 Sep;80:48-60 PMID: 25917982 Abstract During development and reproduction the response to ecdysteroids is mediated by a heterodimeric receptor complex comprising the retinoid X receptor/ultraspiracle (RXR/USP) and the ecdysone receptor (EcR). Here, the role of these receptors in the endocrine control of … Read More

How Did Arthropod Sesquiterpenoids and Ecdysteroids Arise? Comparison of Hormonal Pathway Genes in Noninsect Arthropod Genomes

Qu Z, Kenny NJ, Lam HM, Chan TF, Chu KH, Bendena WG, Tobe SS, Hui JH Genome Biol Evol 2015 Jul;7(7):1951-9 PMID: 26112967 Abstract The phylum Arthropoda contains the largest number of described living animal species, with insects and crustaceans dominating the terrestrial and aquatic environments, respectively. Their successful radiations have long been linked to … Read More