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Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases.

Gritsunov A, Peek J, Diaz Caballero J, Guttman D, Christendat D Plant J. 2018 Jun 11; (): PMID: 29890023 Abstract Quinate is produced and used by many plants in the biosynthesis of chlorogenic acids (CGAs). Chlorogenic acids are astringent and serve to deter herbivory. They also function as antifungal agents and have potent antioxidant properties. … Read More

Variational Infinite Heterogeneous Mixture Model for Semi-supervised Clustering of Heart Enhancers.

Mehdi TF, Singh G, Mitchell JA, Moses AM Bioinformatics 2019 Feb 07; (): PMID: 30753279 Abstract Mammalian genomes can contain thousands of enhancers but only a subset are actively driving gene expression in a given cellular context. Integrated genomic datasets can be harnessed to predict active enhancers. One challenge in integration of large genomic datasets … Read More

A Noisy Analog-to-Digital Converter Connects Cytosolic Calcium Bursts to Transcription Factor Nuclear Localization Pulses in Yeast.

Hsu IS, Strome B, Plotnikov S, Moses AM G3 2019 02 07; 9(2):561-570 PMID: 30573469 Abstract Several examples of transcription factors that show stochastic, unsynchronized pulses of nuclear localization have been described. Here we show that under constant calcium stress, nuclear localization pulses of the transcription factor Crz1 follow stochastic variations in cytosolic calcium concentration. … Read More