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Evolution of Ecdysis and Metamorphosis in Arthropods: The Rise of Regulation of Juvenile Hormone

Cheong SP, Huang J, Bendena WG, Tobe SS, Hui JH Integr. Comp. Biol. 2015 Nov;55(5):878-90 PMID: 26105594 Abstract Arthropods are the most successful group of animals, and are found in diverse habitats; they account for more than 80% of described animal species. A rigid exoskeleton is a common feature that is shared across the different … Read More

A uniquely adaptable pore is consistent with NALCN being an ion sensor

Senatore A, Spafford JD Channels (Austin) 2013 Mar-Apr;7(2):60-8 PMID: 23442378 Abstract NALCN is an intriguing, orphan ion channel among the 4x6TM family of related voltage-gated cation channels, sharing a common architecture of four homologous domains consisting of six transmembrane helices, separated by three cytoplasmic linkers and delimited by N and C-terminal ends. NALCN is one … Read More

Cav3 T-type channels: regulators for gating, membrane expression, and cation selectivity

Senatore A, Guan W, Spafford JD Pflugers Arch. 2014 Apr;466(4):645-60 PMID: 24515291 Abstract Cav3 T-type channels are low-voltage-gated channels with rapid kinetics that are classified among the calcium-selective Cav1 and Cav2 type channels. Here, we outline the fundamental and unique regulators of T-type channels. An ubiquitous and proximally located “gating brake” works in concert with … Read More