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Serotonin-dependent kinetics of feeding bursts underlie a graded response to food availability in C. elegans.

Lee KS, Iwanir S, Kopito RB, Scholz M, Calarco JA, Biron D, Levine E Nat Commun 2017 02 01; 8():14221 PMID: 28145493 Abstract Animals integrate physiological and environmental signals to modulate their food uptake. The nematode C. elegans, whose food uptake consists of pumping bacteria from the environment into the gut, provides excellent opportunities for … Read More

Neuroendocrine modulation sustains the forward motor state.

Lim MA, Chitturi J, Laskova V, Meng J, Findeis D, Wiekenberg A, Mulcahy B, Luo L, Li Y, Lu Y, Hung W, Qu Y, Ho CY, Holmyard D, Ji N, McWhirter R, Samuel AD, Miller DM, Schnabel R, Calarco JA, Zhen M Elife 2016 11 18; 5(): PMID: 27855782 Abstract Neuromodulators shape neural circuit dynamics. … Read More

Regulation of Tissue-Specific Alternative Splicing: C. elegans as a Model System.

Gracida X, Norris AD, Calarco JA Adv. Exp. Med. Biol. 2016; 907():229-61 PMID: 27256389 Abstract Alternative pre-mRNA splicing serves as an elegant mechanism for generating transcriptomic and proteomic diversity between cell and tissue types. In this chapter, we highlight key concepts and outstanding goals in studies of tissue and cell-specific alternative splicing. We place particular … Read More