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Pubmed

Short linear motifs in intrinsically disordered regions modulate HOG signaling capacity.

Strome B, Hsu IS, Li Cheong Man M, Zarin T, Nguyen Ba A, Moses AM BMC Syst Biol 2018 Jul 03; 12(1):75 PMID: 29970070 Abstract The effort to characterize intrinsically disordered regions of signaling proteins is rapidly expanding. An important class of disordered interaction modules are ubiquitous and functionally diverse elements known as short linear … Read More

Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins.

Lu AX, Chong YT, Hsu IS, Strome B, Handfield LF, Kraus O, Andrews BJ, Moses AM Elife 2018 04 05; 7(): PMID: 29620521 Abstract The evaluation of protein localization changes on a systematic level is a powerful tool for understanding how cells respond to environmental, chemical, or genetic perturbations. To date, work in understanding these … Read More

NoLogo: a new statistical model highlights the diversity and suggests new classes of Crm1-dependent nuclear export signals.

Liku ME, Legere EA, Moses AM BMC Bioinformatics 2018 02 27; 19(1):65 PMID: 29482494 Abstract Crm1-dependent Nuclear Export Signals (NESs) are clusters of alternating hydrophobic and non-hydrophobic amino acid residues between 10 to 15 amino acids in length. NESs were largely thought to follow simple consensus patterns, based on which they were categorized into 6-10 … Read More