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EOL-1, the homolog of the mammalian Dom3Z, regulates olfactory learning in C. elegans.

Shen Y, Zhang J, Calarco JA, Zhang Y J. Neurosci. 2014 Oct 01; 34(40):13364-70 PMID: 25274815 Abstract Learning is an essential function of the nervous system. However, our understanding of molecular underpinnings of learning remains incomplete. Here, we characterize a conserved protein EOL-1 that regulates olfactory learning in Caenorhabditis elegans. A recessive allele of eol-1 … Read More

Heritable genome editing in C. elegans via a CRISPR-Cas9 system.

Friedland AE, Tzur YB, Esvelt KM, Colaiácovo MP, Church GM, Calarco JA Nat. Methods 2013 Aug; 10(8):741-3 PMID: 23817069 Abstract We report the use of clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated endonuclease Cas9 to target genomic sequences in the Caenorhabditis elegans germ line using single-guide RNAs that are expressed from a U6 small nuclear … Read More

‘Cryptic’ exons reveal some of their secrets.

Calarco JA Elife 2013 Jan 22; 2():e00476 PMID: 23358458 Abstract By regulating the inclusion of ‘cryptic’ exons in messenger RNA in nerve cells, NOVA proteins are able to influence the abundance of the corresponding proteins.