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The gut microbiome and the hygiene hypothesis of allergic disease. Impact of pets and siblings on infant gut microbiota

Azad MB, Konya T, Maughan H, Guttman DS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, Ann Am Thorac Soc 2014 Jan;11 Suppl 1:S73 PubMed PMID: 24437416 Abstract Rationale: Early-life exposure to pets or siblings is protective against allergic disease, including asthma. These associations are commonly attributed to the “hygiene hypothesis”; however, few studies have … Read More

Next-generation mapping of genetic mutations using bulk population sequencing

Austin RS, Chatfield SP, Desveaux D, Guttman DS Methods Mol. Biol. 2014;1062:301-15 PubMed PMID: 24057374 Abstract Next-generation sequencing platforms have made it possible to very rapidly map genetic mutations in Arabidopsis using whole-genome resequencing against pooled members of an F2 mapping population. In the case of recessive mutations, all individuals expressing the phenotype will be … Read More