|Agriculture & Agrifood Canada
Eastern Cereal and Oilseed Research Centre
960 Carling Ave
Ottawa, ON K1A0C6
|Office phone: 613-759-7619
Fusarium graminearum is a pathogen that infects small grain cereals and deposits mycotoxins in cereals. The accumulation of mycotoxins reduce the value of crops and are toxic to animals. Over the past ten years, we have established research program to study diseases in cereals caused by the phytopathogen Fusarium graminearum and develop technologies to mitigate diseases associated with this fungus. F. graminearum is a causal agent of the head blight diseases of small grain cereals and the mycotoxins that accumulate in the infected cereals represent a major loss of income for farmers worldwide. Our program employs many aspects of genetics and genomics in fundamental and technology transfer research. Mycotoxins are the most significant food safety issue in the international grain marketplace and new stringent regulations on toxin levels in grain will significantly affect the competitiveness of grain in international trade. The development of monocot crops such as wheat and triticale for novel uses (biorefinery, enhanced health products) depends on a sustainable yield, high quality, and minimal pathogen and mycotoxin contamination. Knowledge of the host/pathogen interaction will greatly improve our ability to combine natural resistance strategies and design novel ones in crop germplasm, or interfere with pathogenesis using sustainable crop management protocols (e.g. biological control). Finally, the research program has added to our knowledge of secondary metabolites produced by Fusarium in crops, which have impacts on food safety and monitoring.
|In planta proximity dependent biotin identification (BioID). Khan M, Youn JY, Gingras AC, Subramaniam R, Desveaux D. Sci Rep. 2018 Jun 15;8(1):9212. doi: 10.1038/s41598-018-27500-3.
|Building a protein-interaction network to study Fusarium graminearum pathogenesis. Armand Mirmiran, Darrell Desveaux & Rajagopal Subramaniam. Pages 172-178 | Accepted 11 Feb 2018, Accepted author version posted online: 16 Feb 2018, Published online: 12 Mar 2018.
|Oh, the places they’ll go! A survey of phytopathogen effectors and their host targets. Khan M, Seto D, Subramaniam R, Desveaux D. Plant J. 2018 Feb;93(4):651-663. doi: 10.1111/tpj.13780. Epub 2017 Dec 25.pubmed|
|Whole genome sequencing and comparative genomics of closely related Fusarium Head Blight fungi: Fusarium graminearum, F. meridionale and F. asiaticum. Walkowiak S, Rowland O, Rodrigue N, Subramaniam R. BMC Genomics. 2016 Dec 9;17(1):1014.pubmed|
|Of guards, decoys, baits and traps: pathogen perception in plants by type III effector sensors. Khan M, Subramaniam R, Desveaux D. Curr Opin Microbiol. 2016 Feb;29:49-55. doi: 10.1016/j.mib.2015.10.006. Epub 2015 Nov 18.pubmed|
|Antifungal Saponins from the Maya Medicinal Plant Cestrum schlechtendahlii G. Don (Solanaceae). Chieu Anh Kim Ta, J. Antonio Guerrero-Analco, Elizabeth Roberts, Rui Liu, Christopher D. Mogg, Ammar Saleem, Marco Otárola-Rojas, Luis Poveda, Pablo Sanchez-Vindas, Victor Cal, Federico Caal, Rajagopal Subramaniam, Myron L. Smith, John T. Arnason. First published: 15 December 2015, https://doi.org/10.1002/ptr.5545.citation link|
|Leucine metabolism regulates TRI6 expression and affects deoxynivalenol production and virulence in Fusarium graminearum. Subramaniam R, Narayanan S, Walkowiak S, Wang L, Joshi M, Rocheleau H, Ouellet T, Harris LJ. Mol Microbiol. 2015 Nov;98(4):760-9. doi: 10.1111/mmi.13155. Epub 2015 Sep 15.pubmed|