Angela Lange

faculty_img Academic Title: Professor

Campus: UTM

CSB Appointment: Full

Primary Undergraduate Department:
Biology, UTM

Graduate Programs:
Cell & Systems Biology

Titles and Honors:


Academic or Administrative Appointments:
Research Director, Biology, UTM

Education:
Ph.D. York 1984

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
3359 Mississauga Road North
Mississauga, ON L5L 1C6
Canada
 

 

Contact Information
Office phone: 905-828-3972 
Office: DV 3033 
Lab: DV 3025 
Lab phone: 905-828-3898/5333 
Email: angela.lange@utoronto.ca 
URL: http://www.erin.utoronto.ca/~w3lange/

 

Research Areas
Animal Biology
Molecular Biology
Neurobiology
Physiology

 

Research

The research interests of my laboratory lie within the field of insect physiology. In particular, we are interested in the means by which cells and tissues communicate with one another in order to produce integrated and coordinated output. To this end, we have developed model systems to help identify motor and modulatory input onto the reproductive system, the digestive system and the cardiac system of the locust, Locusta migratoria, the stick insect, Baculum extradentatum, and the medically important hemipteran, Rhodnius prolixus. These inputs must be coordinated in order to produce the correct response at the appropriate time (e.g.egg-laying, absorption of nutrients, circulation). This work entails neurophysiology, neurochemistry, receptor physiology, signal transduction, molecular biology and various physiological bioassays. Our work allows for experimentation at the whole animal level down to the molecular level. Work of this nature can furnish the means of controlling insect pests by development of new insecticides.

 

Publications

2015

Top
Adipokinetic hormone signalling system in the Chagas disease vector, Rhodnius prolixus.Zandawala M, Hamoudi Z, Lange AB, Orchard I.Insect Mol. Biol. 2015 Apr;24(2):264-76
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Myoinhibitors controlling oviduct contraction within the female blood-gorging insect, Rhodnius prolixus.Sedra L, Haddad AS, Lange AB.Gen. Comp. Endocrinol. 2015 Jan;211:62-8
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Identification, characterization and expression of a receptor for the unusual myosuppressin in the blood-feeding bug, Rhodnius prolixus.Lee D, James TE, Lange AB.Insect Mol. Biol. 2015 Feb;24(1):129-37
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Functional characterization and expression analysis of the myoinhibiting peptide receptor in the Chagas disease vector, Rhodnius prolixus.Paluzzi JP, Haddad AS, Sedra L, Orchard I, Lange AB.Mol. Cell. Endocrinol. 2015 Jan;399:143-53
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2014

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K+ absorption by locust gut and inhibition of ileal K+ and water transport by FGLamide allatostatins.Robertson L, Donini A, Lange AB.J. Exp. Biol. 2014 Jul;
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Octopamine modulates a central pattern generator associated with egg-laying in the locust, Locusta migratoria.Wong R, Lange AB.J. Insect Physiol. 2014 Apr;63:1-8
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The distribution and physiological effects of three evolutionarily and sequence-related neuropeptides in Rhodnius prolixus: Adipokinetic hormone, corazonin and adipokinetic hormone/corazonin-related peptide.Patel H, Orchard I, Veenstra JA, Lange AB.Gen. Comp. Endocrinol. 2014 Jan;195:1-8
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The female reproductive system of the kissing bug, Rhodnius prolixus: arrangements of muscles, distribution and myoactivity of two endogenous FMRFamide-like peptides.Sedra L, Lange AB.Peptides 2014 Mar;53:140-7
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2013

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Evidence for a conserved CCAP-signaling pathway controlling ecdysis in a hemimetabolous insect, Rhodnius prolixus.Lee D, Orchard I, Lange AB.Front Neurosci 2013;7:207
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Identification and expression of the CCAP receptor in the Chagas' disease vector, Rhodnius prolixus, and its involvement in cardiac control.Lee D, Vanden Broeck J, Lange AB.PLoS ONE 2013;8(7):e68897
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2012

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The distribution and physiological effects of the myoinhibiting peptides in the kissing bug, rhodnius prolixus.Lange AB, Alim U, Vandersmissen HP, Mizoguchi A, Vanden Broeck J, Orchard I.Front Neurosci 2012;6:98
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The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST.Robertson L, Rodriguez EP, Lange AB.J. Exp. Biol. 2012 Oct;215(Pt 19):3394-402
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An unusual myosuppressin from the blood-feeding bug Rhodnius prolixus.Lee D, Taufique H, da Silva R, Lange AB.J. Exp. Biol. 2012 Jun;215(Pt 12):2088-95
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The regulation of cardiac activity by nitric oxide (NO) in the Vietnamese stick insect, Baculum extradentatum.da Silva R, da Silva SR, Lange AB.Cell. Signal. 2012 Jun;24(6):1344-50
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Sequencing and biological effects of an adipokinetic/hypertrehalosemic peptide in the stick insect, Baculum extradentatum.Malik A, Gäde G, Lange AB.Peptides 2012 Mar;34(1):51-6
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2011

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The Proctolin Gene and Biological Effects of Proctolin in the Blood-Feeding Bug, Rhodnius prolixus.Orchard I, Lee do H, da Silva R, Lange AB.Front Endocrinol (Lausanne) 2011;2:59
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Crustacean cardioactive peptide in the Chagas' disease vector, Rhodnius prolixus: presence, distribution and physiological effects.Lee do H, Lange AB.Gen. Comp. Endocrinol. 2011 Oct;174(1):36-43
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Evidence of a central pattern generator regulating spermathecal muscle activity in Locusta migratoria and its coordination with oviposition.da Silva R, Lange AB.J. Exp. Biol. 2011 Mar;214(Pt 5):757-63
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Effects of crustacean cardioactive peptide on the hearts of two Orthopteran insects, and the demonstration of a Frank-Starling-like effect.da Silva SR, da Silva R, Lange AB.Gen. Comp. Endocrinol. 2011 Apr;171(2):218-24
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2010

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Effects of the mycotoxin destruxin A on Locusta migratoria visceral muscles.Ruiz-Sanchez E, Lange AB, Orchard I.Toxicon 2010 Nov;56(6):1043-51
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Neuropeptide action in insects and crustaceans.Mykles DL, Adams ME, Gäde G, Lange AB, Marco HG, Orchard I.Physiol. Biochem. Zool. 2010 Sep-Oct;83(5):836-46
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Neural substrate and allatostatin-like innervation of the gut of Locusta migratoria.Robertson L, Lange AB.J. Insect Physiol. 2010 Aug;56(8):893-901
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Rhythmic behaviour and pattern-generating circuits in the locust: key concepts and recent updates.Ayali A, Lange AB.J. Insect Physiol. 2010 Aug;56(8):834-43
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Effects of the cyclopeptide mycotoxin destruxin A on the Malpighian tubules of Rhodnius prolixus (Stål).Ruiz-Sanchez E, Orchard I, Lange AB.Toxicon 2010 Jun;55(6):1162-70
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2009

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Neuropeptides modulate the heart of the stick insect Baculum extradentatum.Lange AB, Calvin A, da Silva R.Ann. N. Y. Acad. Sci. 2009 Apr;1163:448-50
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Neural mechanisms coordinating the female reproductive system in the locust.Lange AB.Front Biosci (Landmark Ed) 2009;14:4401-15
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Tyramine: from octopamine precursor to neuroactive chemical in insects.Lange AB.Gen. Comp. Endocrinol. 2009 May;162(1):18-26
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2008

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Tyramine as a possible neurotransmitter/neuromodulator at the spermatheca of the African migratory locust, Locusta migratoria.da Silva R, Lange AB.J. Insect Physiol. 2008 Aug;54(8):1306-13
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Peptidergic control of the heart of the stick insect, Baculum extradentatum.Ejaz A, Lange AB.Peptides 2008 Feb;29(2):214-25
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Dopaminergic control of foregut contractions in Locusta migratoria.Lange AB, Chan K.J. Insect Physiol. 2008 Jan;54(1):222-30
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2007

Top
Neural and hormonal control of muscular activity of the spermatheca in the locust, Locusta migratoria.Lange AB, da Silva R.Peptides 2007 Jan;28(1):174-84
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2006

Top
The association of crustacean cardioactive peptide with the spermatheca of the African migratory locust, Locusta migratoria.da Silva R, Lange AB.J. Insect Physiol. 2006 Apr;52(4):399-409
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Proctolin-like immunoreactivity in the central and peripheral nervous systems of the locust, Locusta migratoria.Clark L, Agricola HJ, Lange AB.Peptides 2006 Mar;27(3):549-58
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Proctolin: A possible releasing factor in the corpus cardiacum/corpus allatum of the locust.Clark L, Zhang JR, Tobe S, Lange AB.Peptides 2006 Mar;27(3):559-66
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2005

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Isolation, cloning, and tissue expression of a putative octopamine/tyramine receptor from locust visceral muscle tissues.Molaei G, Paluzzi JP, Bendena WG, Lange AB.Arch. Insect Biochem. Physiol. 2005 Jul;59(3):132-49
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The presence and distribution of crustacean cardioactive peptide in the central and peripheral nervous system of the stick insect, Baculum extradentatum.Lange AB, Patel K.Regul. Pept. 2005 Jul;129(1-3):191-201
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2004

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A neurohormonal role for serotonin in the control of locust oviducts.Lange AB.Arch. Insect Biochem. Physiol. 2004 Aug;56(4):179-90
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Evidence for a possible neurotransmitter/neuromodulator role of tyramine on the locust oviducts.Donini A, Lange AB.J. Insect Physiol. 2004 Apr;50(4):351-61
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2003

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The association of serotonin with the alimentary canal of the African migratory locust, Locusta migratoria: distribution, physiology and pharmacological profile.Molaei G, Lange AB.J. Insect Physiol. 2003 Nov;49(11):1073-82
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2002

Top
A review of the involvement of proctolin as a cotransmitter and local neurohormone in the oviduct of the locust, Locusta migratoria.Lange AB.Peptides 2002 Nov;23(11):2063-70
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Evidence for crustacean cardioactive peptide-like innervation of the gut in Locusta migratoria.Donini A, Ngo C, Lange AB.Peptides 2002 Nov;23(11):1915-23
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The effects of crustacean cardioactive peptide on locust oviducts are calcium-dependent.Donini A, Lange AB.Peptides 2002 Apr;23(4):683-91
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Evidence for the association of FMRFamide-related peptides with the spermatheca of Locusta migratoria.Clark J, Lange AB.Peptides 2002 Apr;23(4):613-9
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