Bebhinn Treanor

faculty_img Academic Title: Assistant Professor

Campus: UTSC

CSB Appointment: Full

Primary Undergraduate Department:
Biological Sciences, UTSC

Graduate Programs:
Cell & Systems Biology
Physiology

Titles and Honors:


Academic or Administrative Appointments:


Education:
Ph.D. Imperial College London 2006
B.Sc.. University of Calgary 2001

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4
Canada
 

 

Contact Information
Office phone: 416-208-2926 
Office: SW 567 
Lab:  
Lab phone:  
Email: btreanor@utsc.utoronto.ca 
URL:

 

Research Areas
Cell Biology

 

Research

Over the last decade the ability to resolve biochemical events within individual cells has transformed our view of intracellular signalling and provided vital spatio-temporal information about the activation of cell surface receptors. What has emerged is that the organization and dynamics of cell surface receptors plays a critical role in directing cell signalling and effector cell fate. My research focuses on the molecular mechanisms controlling the organization and dynamics of immune cell receptors and the functional significance for immune cell activation using cutting edge optical microscopy to visualize individual molecules and macromolecular clusters of cell surface proteins in single cells. My current research investigates the potential for extracellular regulatory mechanisms for receptor organization, such as glycan-based domains generated by the binding of galectins to cell surface glycoproteins. The galectins are a family of lectins that can bind b-galactoside on cell surface glycoproteins to form an extracellular molecular lattice. My laboratory uses advanced optical microscopy techniques to explore how these cell-surface scaffolding proteins could modulate the interaction, function and turnover of immune cell glycoproteins.

 

Publications

2013

Top
The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling.Mattila PK, Feest C, Depoil D, Treanor B, Montaner B, Otipoby KL, Carter R, Justement LB, Bruckbauer A, Batista FD.Immunity 2013 Mar;38(3):461-74
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2012

Top
B-cell receptor: from resting state to activate.Treanor B.Immunology 2012 May;136(1):21-7
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2011

Top
Editorial: Counting the carbs: a memory B cell makeover.Treanor B, Cancro MP.J. Leukoc. Biol. 2011 Jul;90(1):1-3
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Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity.Treanor B, Depoil D, Bruckbauer A, Batista FD.J. Exp. Med. 2011 May;208(5):1055-68
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2010

Top
Visualizing a role for the actin cytoskeleton in the regulation of B-cell activation.Batista FD, Treanor B, Harwood NE.Immunol. Rev. 2010 Sep;237(1):191-204
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Organisation and dynamics of antigen receptors: implications for lymphocyte signalling.Treanor B, Batista FD.Curr. Opin. Immunol. 2010 Jun;22(3):299-307
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The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor.Treanor B, Depoil D, Gonzalez-Granja A, Barral P, Weber M, Dushek O, Bruckbauer A, Batista FD.Immunity 2010 Feb;32(2):187-99
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2009

Top
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.Randall KL, Lambe T, Johnson AL, Johnson A, Treanor B, Kucharska E, Domaschenz H, Whittle B, Tze LE, Enders A, Crockford TL, Bouriez-Jones T, Alston D, Cyster JG, Lenardo MJ, Mackay F, Deenick EK, Tangye SG, Chan TD, Camidge T, Brink R, Vinuesa CG, Batista FD, Cornall RJ, Goodnow CC.Nat. Immunol. 2009 Dec;10(12):1283-91
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Microsignalosomes: spatially resolved receptor signalling.Treanor B, Harwood NE, Batista FD.Biochem. Soc. Trans. 2009 Oct;37(Pt 5):1014-8
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Early events of B cell activation by antigen.Depoil D, Weber M, Treanor B, Fleire SJ, Carrasco YR, Harwood NE, Batista FD.Sci Signal 2009;2(63):pt1
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2008

Top
Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen.Weber M, Treanor B, Depoil D, Shinohara H, Harwood NE, Hikida M, Kurosaki T, Batista FD.J. Exp. Med. 2008 Apr;205(4):853-68
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CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand.Depoil D, Fleire S, Treanor BL, Weber M, Harwood NE, Marchbank KL, Tybulewicz VL, Batista FD.Nat. Immunol. 2008 Jan;9(1):63-72
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2007

Top
Mechanistic insight into lymphocyte activation through quantitative imaging and theoretical modelling.Treanor B, Batista FD.Curr. Opin. Immunol. 2007 Aug;19(4):476-83
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The role of integrins and coreceptors in refining thresholds for B-cell responses.Batista FD, Arana E, Barral P, Carrasco YR, Depoil D, Eckl-Dorna J, Fleire S, Howe K, Vehlow A, Weber M, Treanor B.Immunol. Rev. 2007 Aug;218:197-213
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2006

Top
Microclusters of inhibitory killer immunoglobulin-like receptor signaling at natural killer cell immunological synapses.Treanor B, Lanigan PM, Kumar S, Dunsby C, Munro I, Auksorius E, Culley FJ, Purbhoo MA, Phillips D, Neil MA, Burshtyn DN, French PM, Davis DM.J. Cell Biol. 2006 Jul;174(1):153-61
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2004

Top
Time-domain fluorescence lifetime imaging applied to biological tissue.Elson D, Requejo-Isidro J, Munro I, Reavell F, Siegel J, Suhling K, Tadrous P, Benninger R, Lanigan P, McGinty J, Talbot C, Treanor B, Webb S, Sandison A, Wallace A, Davis D, Lever J, Neil M, Phillips D, Stamp G, French P.Photochem. Photobiol. Sci. 2004 Aug;3(8):795-801
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