George Espie

faculty_img Academic Title: Professor

Campus: UTM

CSB Appointment: Full

Primary Undergraduate Department:
Biology, UTM

Graduate Programs:
Cell & Systems Biology

Titles and Honors:


Academic or Administrative Appointments:


Education:
Ph.D. York University 1985
B.Sc. York University 1979

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
3359 Mississauga Road North
Mississauga, ON L5L 1C6
Canada
 

 

Contact Information
Office phone: 905-828-5380 
Office: DV 4053 
Lab: DV 4028 
Lab phone: 905-828-5219 
Email: george.espie@utoronto.ca 
URL: LAB

 

Research Areas
Biotechnology
Cell Biology
Microbiology
Molecular Biology
Physiology
Plant Biology
Structural Biology

 

Research


Microbial physiology, molecular biology, biochemistry and photosynthesis. Current research is directed towards: identifying the molecular components essential to the CO2 – concentrating mechanism of aquatic, photosynthetic microorganisms; defining the role of carbonic anhydrase in photosynthesis; acquiring an understanding of the biochemical mechanisms involved in the active transport HCO3-; regulation of expression of the CO2/HCO3- transport systems and the control of photosynthetic electron transport by CO2/HCO3-.Using molecular and biochemical tools, we are also analysing the structure, assembly and protein targeting to carboxysomes, the unique CO2 fixing organelles of cyanobacteria. Also, in collaboration with colleagues in chemical engineering, we are using our expertise in microbial photosynthesis to investigate the industrial use of microalgal biofilms grown in photobioreactors as a source for biofuels and a means for waste water remediation.

 

Publications

2014

Top
Identification and characterization of a carboxysomal γ-carbonic anhydrase from the cyanobacterium Nostoc sp. PCC 7120.de Araujo C, Arefeen D, Tadesse Y, Long BM, Price GD, Rowlett RS, Kimber MS, Espie GS.Photosyn. Res. 2014 Sep;121(2-3):135-50
pubmed

2013

Top
Algae biofilm growth and the potential to stimulate lipid accumulation through nutrient starvation.Schnurr PJ, Espie GS, Allen DG.Bioresour. Technol. 2013 May;136:337-44
pubmed

2012

Top
Inactivation of a low temperature-induced RNA helicase in Synechocystis sp. PCC 6803: physiological and morphological consequences.Rosana AR, Ventakesh M, Chamot D, Patterson-Fortin LM, Tarassova O, Espie GS, Owttrim GW.Plant Cell Physiol. 2012 Apr;53(4):646-58
pubmed

2011

Top
Physiological characterization and light response of the CO2-concentrating mechanism in the filamentous cyanobacterium Leptolyngbya sp. CPCC 696.de Araujo ED, Patel J, de Araujo C, Rogers SP, Short SM, Campbell DA, Espie GS.Photosyn. Res. 2011 Sep;109(1-3):85-101
pubmed
Carboxysomes: cyanobacterial RubisCO comes in small packages.Espie GS, Kimber MS.Photosyn. Res. 2011 Sep;109(1-3):7-20
pubmed

2010

Top
Structural basis of the oxidative activation of the carboxysomal gamma-carbonic anhydrase, CcmM.Peña KL, Castel SE, de Araujo C, Espie GS, Kimber MS.Proc. Natl. Acad. Sci. U.S.A. 2010 Feb;107(6):2455-60
pubmed

2009

Top
Optical microscopy in photosynthesis.Cisek R, Spencer L, Prent N, Zigmantas D, Espie GS, Barzda V.Photosyn. Res. 2009 Nov-Dec;102(2-3):111-41
pubmed

2008

Top
A multiprotein bicarbonate dehydration complex essential to carboxysome function in cyanobacteria.Cot SS, So AK, Espie GS.J. Bacteriol. 2008 Feb;190(3):936-45
pubmed

2007

Top
Involvement of the cynABDS operon and the CO2-concentrating mechanism in the light-dependent transport and metabolism of cyanate by cyanobacteria.Espie GS, Jalali F, Tong T, Zacal NJ, So AK.J. Bacteriol. 2007 Feb;189(3):1013-24
pubmed

2006

Top
Mechanism of the down regulation of photosynthesis by blue light in the Cyanobacterium synechocystis sp. PCC 6803.Scott M, McCollum C, Vasil'ev S, Crozier C, Espie GS, Krol M, Huner NP, Bruce D.Biochemistry 2006 Jul;45(29):8952-8
pubmed

2004

Top
A novel evolutionary lineage of carbonic anhydrase (epsilon class) is a component of the carboxysome shell.So AK, Espie GS, Williams EB, Shively JM, Heinhorst S, Cannon GC.J. Bacteriol. 2004 Feb;186(3):623-30
pubmed

2002

Top
Mitochondrial-driven bicarbonate transport supports photosynthesis in a marine microalga.Huertas IE, Colman B, Espie GS.Plant Physiol. 2002 Sep;130(1):284-91
pubmed
The energy source for CO2 transport in the marine microalga Nannochloris atomus.Huertas IE, Espie GS, Colman B.Planta 2002 Apr;214(6):947-53
pubmed
Effects of carbon nutrition on the physiological expression of HCO3- transport and the CO2-concentrating mechanism in the Cyanobacterium chlorogloeopsis sp. ATCC 27193.Skleryk RS, So AK, Espie GS.Planta 2002 Feb;214(4):572-83
pubmed
Characterization of a mutant lacking carboxysomal carbonic anhydrase from the cyanobacterium Synechocystis PCC6803.So AK, John-McKay M, Espie GS.Planta 2002 Jan;214(3):456-67
pubmed