Greg Vanlerberghe

faculty_img Academic Title: Professor

Campus: UTSC

CSB Appointment: Full

Primary Undergraduate Department:
Biological Sciences, UTSC

Graduate Programs:
Cell & Systems Biology

Titles and Honors:
Academic or Administrative Appointments:
Education:
Ph.D. Queen’s University 1991
M.Sc. University of Western Ontario 1987
B.Sc. University of Western Ontario 1984

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4
Canada

 

Contact Information
Office phone: 416-208-2742
Office:  SY 262
Lab:  SY 270
Lab phone: 416-287-7240
Email: gregv@utsc.utoronto.ca
URL: http://www.scar.utoronto.ca/~gregv/

 

Research Areas
Plant Biology

 

Research

Plant growth at all stages depends on the ability of metabolism to function effectively under a wide range of cellular and environmental conditions. An enhanced understanding of how metabolism functions, particularly under less favorable conditions, is therefore a central component of intensifying efforts worldwide to improve plant productivity for food and many other uses. We investigate the impact of abiotic and biotic stresses (such as drought, low temperature, nutrient deficiency, high carbon dioxide, low oxygen, pathogen attack) on metabolism. Our goal is to uncover the signature responses of carbon and energy metabolism to stress, and to elucidate how these responses support acclimation to stress. An emphasis is placed on the two major energy transducing organelles of the plant cell (the mitochondrion and the chloroplast) and on the interactions between major metabolic hubs including respiration, photosynthesis and nutrient assimilation. In addition, the impact of the related reactive oxygen and reactive nitrogen metabolic networks is investigated. These reactive species can damage metabolism but are also key signaling molecules supporting stress acclimation. To advance our goals, an integrative approach is taken, whereby processes are studied at the whole plant, cell, organelle, and molecular level using a combination of physiological, biochemical and molecular biological approaches. This includes growth of plants and suspension cells under defined conditions; generation and analysis of transgenic plants; gene expression analyses; leaf gas exchange and chlorophyll fluorescence analyses; organelle isolation and analyses; biochemical analyses of enzymes and metabolites, and confocal imaging and biochemical analysis of reactive oxygen and nitrogen species.

 

Publications

2014

Top
Knockdown of mitochondrial alternative oxidase induces the 'stress state' of signaling molecule pools in Nicotiana tabacum, with implications for stomatal function.Cvetkovska M, Dahal K, Alber NA, Jin C, Cheung M, Vanlerberghe GC.New Phytol. 2014 Jul;203(2):449-61
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2013

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A lack of mitochondrial alternative oxidase compromises capacity to recover from severe drought stress.Wang J, Vanlerberghe GC.Physiol Plant 2013 Apr;
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Alternative Oxidase: A Mitochondrial Respiratory Pathway to Maintain Metabolic and Signaling Homeostasis during Abiotic and Biotic Stress in Plants.Vanlerberghe GC.Int J Mol Sci 2013;14(4):6805-47
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The signaling role of a mitochondrial superoxide burst during stress.Cvetkovska M, Alber NA, Vanlerberghe GC.Plant Signal Behav 2013 Jan;8(1):e22749
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Alternative oxidase impacts the plant response to biotic stress by influencing the mitochondrial generation of reactive oxygen species.Cvetkovska M, Vanlerberghe GC.Plant Cell Environ. 2013 Mar;36(3):721-32
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2012

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Alternative oxidase modulates leaf mitochondrial concentrations of superoxide and nitric oxide.Cvetkovska M, Vanlerberghe GC.New Phytol. 2012 Jul;195(1):32-9
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Coordination of a mitochondrial superoxide burst during the hypersensitive response to bacterial pathogen in Nicotiana tabacum.Cvetkovska M, Vanlerberghe GC.Plant Cell Environ. 2012 Jun;35(6):1121-36
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2011

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Impact of mitochondrial alternative oxidase expression on the response of Nicotiana tabacum to cold temperature.Wang J, Rajakulendran N, Amirsadeghi S, Vanlerberghe GC.Physiol Plant 2011 Aug;142(4):339-51
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2010

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The product of the alternative oxidase is still H2O.Møller IM, Rasmusson AG, Siedow JJ, Vanlerberghe GC.Arch. Biochem. Biophys. 2010 Mar;495(1):93-4; author reply 95-6
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2009

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Alternative oxidase in animals: unique characteristics and taxonomic distribution.McDonald AE, Vanlerberghe GC, Staples JF.J. Exp. Biol. 2009 Aug;212(Pt 16):2627-34
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Is the maintenance of homeostatic mitochondrial signaling during stress a physiological role for alternative oxidase?.Vanlerberghe GC, Cvetkovska M, Wang J.Physiol Plant 2009 Dec;137(4):392-406
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2007

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A glucocorticoid-inducible gene expression system can cause growth defects in tobacco.Amirsadeghi S, McDonald AE, Vanlerberghe GC.Planta 2007 Jul;226(2):453-63
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2006

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Origins, evolutionary history, and taxonomic distribution of alternative oxidase and plastoquinol terminal oxidase.McDonald AE, Vanlerberghe GC.Comp. Biochem. Physiol. Part D Genomics Proteomics 2006 Sep;1(3):357-64
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Changes in plant mitochondrial electron transport alter cellular levels of reactive oxygen species and susceptibility to cell death signaling molecules.Amirsadeghi S, Robson CA, McDonald AE, Vanlerberghe GC.Plant Cell Physiol. 2006 Nov;47(11):1509-19
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2005

Top
The role of alternative oxidase in modulating carbon use efficiency and growth during macronutrient stress in tobacco cells.Sieger SM, Kristensen BK, Robson CA, Amirsadeghi S, Eng EW, Abdel-Mesih A, Møller IM, Vanlerberghe GC.J. Exp. Bot. 2005 Jun;56(416):1499-515
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Alternative oxidase and plastoquinol terminal oxidase in marine prokaryotes of the Sargasso Sea.McDonald AE, Vanlerberghe GC.Gene 2005 Apr;349:15-24
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2003

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Prokaryotic orthologues of mitochondrial alternative oxidase and plastid terminal oxidase.McDonald AE, Amirsadeghi S, Vanlerberghe GC.Plant Mol. Biol. 2003 Dec;53(6):865-76
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2002

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Methods and approaches to study plant mitochondrial alternative oxidase.McDonald AE, Sieger SM, Vanlerberghe GC.Physiol Plant 2002 Oct;116(2):135-143
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Transgenic plant cells lacking mitochondrial alternative oxidase have increased susceptibility to mitochondria-dependent and -independent pathways of programmed cell death.Robson CA, Vanlerberghe GC.Plant Physiol. 2002 Aug;129(4):1908-20
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Mitochondrial alternative oxidase is not a critical component of plant viral resistance but may play a role in the hypersensitive response.Ordog SH, Higgins VJ, Vanlerberghe GC.Plant Physiol. 2002 Aug;129(4):1858-65
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Induction of mitochondrial alternative oxidase in response to a cell signal pathway down-regulating the cytochrome pathway prevents programmed cell death.Vanlerberghe GC, Robson CA, Yip JY.Plant Physiol. 2002 Aug;129(4):1829-42
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2001

Top
Mitochondrial alternative oxidase acts to dampen the generation of active oxygen species during a period of rapid respiration induced to support a high rate of nutrient uptake.Yip JY, Vanlerberghe GC.Physiol Plant 2001 Jul;112(3):327-333
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1997

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ALTERNATIVE OXIDASE: From Gene to Function.Vanlerberghe GC, McIntosh L.Annu. Rev. Plant Physiol. Plant Mol. Biol. 1997 Jun;48:703-734
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