Guojun Yang

faculty_img Academic Title: Assistant Professor

Campus: UTM

CSB Appointment: Full

Primary Undergraduate Department:
Biology, UTM

Graduate Programs:
Cell & Systems Biology
Developmental Biology

Titles and Honors
Academic or Administrative Appointments
Education:
Ph.D. Texas A&M University

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
3359 Mississauga Road North
Mississauga, ON L5L 1C6
Canada

 

Contact Information
Office phone: 905-569-4751
Office: DV 3035
Lab: DV 4021
Lab phone: 905-828-3988
Email: gage.yang@utoronto.ca
URL: http://individual.utoronto.ca/gyang

 

Research Areas
Animal Biology
Bioinformatics & Computational Biology
Biotechnology
Comparative Genomics
Evolutionary Biology
Genetics
Molecular Biology
Plant Biology
Synthetic Biology
Systems Biology

 

Research

Transposable elements (TEs) form a major community in eukaryotic genome ecosystems, where they often account for at least half of total content. The discovery of transposons has forced biologists to view genomes as much more dynamic systems than previously imagined. In addition, TE derived DNA tools are widely used in gene discovery and transgenesis. The most intriguing issues surrounding TEs are their interaction with host genome and their persistent proliferation during evolution despite being mutagens. Our research aims to understand how transposable elements shape genome function and evolution.

 

Publications

Link to curated list

 

2014

Top
Procedures for Mucosal Immunization and Analyses of Cellular Immune Response to Candidate HIV Vaccines in Murine and Nonhuman Primate Models.Singh S, Nehete P, Hanley P, Nehete B, Yang G, He H, Anthony SM, Schluns KS, Sastry KJ.Methods Mol. Biol. 2014;1184:417-55
pubmed
Tc1-like transposable elements in plant genomes.Liu Y, Yang G.Mob DNA 2014;5:17
pubmed
Sublingual vaccination induces mucosal and systemic adaptive immunity for protection against lung tumor challenge.Singh S, Yang G, Schluns KS, Anthony SM, Sastry KJ.PLoS ONE 2014;9(3):e90001
pubmed

2013

Top
Phenotypic and functional characterization of lymphocytes from different age groups of Bolivian squirrel monkeys (Saimiri boliviensis boliviensis).Nehete PN, Hanley PW, Nehete BP, Yang G, Ruiz JC, Williams L, Abee CR, Sastry KJ.PLoS ONE 2013;8(11):e79836
pubmed
On a class of two-dimensional Douglas and projectively flat Finsler metrics.Yang G.ScientificWorldJournal 2013;2013:291491
pubmed
Miniature inverted-repeat transposable elements: discovery, distribution, and activity.Fattash I, Rooke R, Wong A, Hui C, Luu T, Bhardwaj P, Yang G.Genome 2013 Sep;56(9):475-86
pubmed
Birth of three stowaway-like MITE families via microhomology-mediated miniaturization of a Tc1/Mariner element in the yellow fever mosquito.Yang G, Fattash I, Lee CN, Liu K, Cavinder B.Genome Biol Evol 2013;5(10):1937-48
pubmed
Draft genome sequence of the mulberry tree Morus notabilis.He N, Zhang C, Qi X, Zhao S, Tao Y, Yang G, Lee TH, Wang X, Cai Q, Li D, Lu M, Liao S, Luo G, He R, Tan X, Xu Y, Li T, Zhao A, Jia L, Fu Q, Zeng Q, Gao C, Ma B, Liang J, Wang X, Shang J, Song P, Wu H, Fan L, Wang Q, Shuai Q, Zhu J, Wei C, Zhu-Salzman K, Jin D, Wang J, Liu T, Yu M, Tang C, Wang Z, Dai F, Chen J, Liu Y, Zhao S, Lin T, Zhang S, Wang J, Wang J, Yang H, Yang G, Wang J, Paterson AH, Xia Q, Ji D, Xiang Z.Nat Commun 2013;4:2445
pubmed
Comparison of systemic and mucosal immunization with helper-dependent adenoviruses for vaccination against mucosal challenge with SHIV.Weaver EA, Nehete PN, Nehete BP, Yang G, Buchl SJ, Hanley PW, Palmer D, Montefiori DC, Ferrari G, Ng P, Sastry KJ, Barry MA.PLoS ONE 2013;8(7):e67574
pubmed
MITE Digger, an efficient and accurate algorithm for genome wide discovery of miniature inverted repeat transposable elements.Yang G.BMC Bioinformatics 2013;14:186
pubmed
A rice Stowaway MITE for gene transfer in yeast.Fattash I, Bhardwaj P, Hui C, Yang G.PLoS ONE 2013;8(5):e64135
pubmed
HIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complex.Wang X, Singh S, Jung HY, Yang G, Jun S, Sastry KJ, Park JI.J. Biol. Chem. 2013 May;288(22):15474-80
pubmed
Nerium oleander derived cardiac glycoside oleandrin is a novel inhibitor of HIV infectivity.Singh S, Shenoy S, Nehete PN, Yang P, Nehete B, Fontenot D, Yang G, Newman RA, Sastry KJ.Fitoterapia 2013 Jan;84:32-9
pubmed

2012

Top
ATon, abundant novel nonautonomous mobile genetic elements in yellow fever mosquito (Aedes aegypti).Yang G, Wong A, Rooke R.BMC Genomics 2012;13:283
pubmed

2011

Top
[Effects of maternal lead exposure on the expression of Abeta40 in the hippocampus of the filial mice].Li N, Yang G, Qiao M, Zhen Y, Li W.Wei Sheng Yan Jiu 2011 Nov;40(6):779-81
pubmed
Bioinformatics and genomic analysis of transposable elements in eukaryotic genomes.Janicki M, Rooke R, Yang G.Chromosome Res. 2011 Aug;19(6):787-808
pubmed
Functional impairment of central memory CD4 T cells is a potential early prognostic marker for changing viral load in SHIV-infected rhesus macaques.He H, Nehete PN, Nehete B, Wieder E, Yang G, Buchl S, Sastry KJ.PLoS ONE 2011;6(5):e19607
pubmed
Isolation and characterization of a rice glutathione S-transferase gene promoter regulated by herbicides and hormones.Hu T, He S, Yang G, Zeng H, Wang G, Chen Z, Huang X.Plant Cell Rep. 2011 Apr;30(4):539-49
pubmed
TE Displayer for post-genomic analysis of transposable elements.Rooke R, Yang G.Bioinformatics 2011 Jan;27(2):286-7
pubmed

2010

Top
Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator.Jin R, Yang G, Li G.Neurobiol. Dis. 2010 Jun;38(3):376-85
pubmed
CD122+CD8+ Treg suppress vaccine-induced antitumor immune responses in lymphodepleted mice.Wang LX, Li Y, Yang G, Pang PY, Haley D, Walker EB, Urba WJ, Hu HM.Eur. J. Immunol. 2010 May;40(5):1375-85
pubmed
Inflammatory mechanisms in ischemic stroke: role of inflammatory cells.Jin R, Yang G, Li G.J. Leukoc. Biol. 2010 May;87(5):779-89
pubmed

2009

Top
Tuned for transposition: molecular determinants underlying the hyperactivity of a Stowaway MITE.Yang G, Nagel DH, Feschotte C, Hancock CN, Wessler SR.Science 2009 Sep;325(5946):1391-4
pubmed
Determinants in CaV1 channels that regulate the Ca2+ sensitivity of bound calmodulin.Halling DB, Georgiou DK, Black DJ, Yang G, Fallon JL, Quiocho FA, Pedersen SE, Hamilton SL.J. Biol. Chem. 2009 Jul;284(30):20041-51
pubmed
Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins.Fallon JL, Baker MR, Xiong L, Loy RE, Yang G, Dirksen RT, Hamilton SL, Quiocho FA.Proc. Natl. Acad. Sci. U.S.A. 2009 Mar;106(13):5135-40
pubmed

2008

Top
Efficient cross-presentation depends on autophagy in tumor cells.Li Y, Wang LX, Yang G, Hao F, Urba WJ, Hu HM.Cancer Res. 2008 Sep;68(17):6889-95
pubmed

2007

Top
Transposition of the rice miniature inverted repeat transposable element mPing in Arabidopsis thaliana.Yang G, Zhang F, Hancock CN, Wessler SR.Proc. Natl. Acad. Sci. U.S.A. 2007 Jun;104(26):10962-7
pubmed

2006

Top
Dramatic amplification of a rice transposable element during recent domestication.Naito K, Cho E, Yang G, Campbell MA, Yano K, Okumoto Y, Tanisaka T, Wessler SR.Proc. Natl. Acad. Sci. U.S.A. 2006 Nov;103(47):17620-5
pubmed
A rice Tc1/mariner-like element transposes in yeast.Yang G, Weil CF, Wessler SR.Plant Cell 2006 Oct;18(10):2469-78
pubmed
Efficacy of GM-CSF-producing tumor vaccine after docetaxel chemotherapy in mice bearing established Lewis lung carcinoma.Chu Y, Wang LX, Yang G, Ross HJ, Urba WJ, Prell R, Jooss K, Xiong S, Hu HM.J. Immunother. 2006 Jul-Aug;29(4):367-80
pubmed
Combined IL-21 and low-dose IL-2 therapy induces anti-tumor immunity and long-term curative effects in a murine melanoma tumor model.He H, Wisner P, Yang G, Hu HM, Haley D, Miller W, O'Hara A, Alvord WG, Clegg CH, Fox BA, Urba WJ, Walker EB.J Transl Med 2006;4:24
pubmed
HideNseek, a post-genome approach to locate transgenes exemplified in Arabidopsis thaliana.Yang G, Hall TC.Bioinformatics 2006 Mar;22(5):523-6
pubmed

2005

Top
Interleukin-7-dependent expansion and persistence of melanoma-specific T cells in lymphodepleted mice lead to tumor regression and editing.Wang LX, Li R, Yang G, Lim M, O'Hara A, Chu Y, Fox BA, Restifo NP, Urba WJ, Hu HM.Cancer Res. 2005 Nov;65(22):10569-77
pubmed
Organization, not duplication, triggers silencing in a complex transgene locus in rice.Yang G, Lee YH, Jiang Y, Kumpatla SP, Hall TC.Plant Mol. Biol. 2005 Jun;58(3):351-66
pubmed
A two-edged role for the transposable element Kiddo in the rice ubiquitin2 promoter.Yang G, Lee YH, Jiang Y, Shi X, Kertbundit S, Hall TC.Plant Cell 2005 May;17(5):1559-68
pubmed

2004

Top
Reduction of retrovirus-induced immunosuppression by in vivo modulation of T cells during acute infection.He H, Messer RJ, Sakaguchi S, Yang G, Robertson SJ, Hasenkrug KJ.J. Virol. 2004 Nov;78(21):11641-7
pubmed
Functional impairment of CD8(+) T cells by regulatory T cells during persistent retroviral infection.Dittmer U, He H, Messer RJ, Schimmer S, Olbrich AR, Ohlen C, Greenberg PD, Stromnes IM, Iwashiro M, Sakaguchi S, Evans LH, Peterson KE, Yang G, Hasenkrug KJ.Immunity 2004 Mar;20(3):293-303
pubmed

2003

Top
MAK, a computational tool kit for automated MITE analysis.Yang G, Hall TC.Nucleic Acids Res. 2003 Jul;31(13):3659-65
pubmed
MDM-1 and MDM-2: two mutator-derived MITE families in rice.Yang G, Hall TC.J. Mol. Evol. 2003 Mar;56(3):255-64
pubmed