Ian Orchard

faculty_img Academic Title: Professor

Campus: UTM

CSB Appointment: Full

Primary Undergraduate Department:
Biology, UTM

Graduate Programs:
Cell & Systems Biology
Genome Biology & Bioinformatics

Titles and Honors:
University of Toronto Distinguished Professor

Academic or Administrative Appointments:


Education:
Ph.D D.Sc. University of Birmingham, UK
B.Sc. University of Birmingham, UK

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
3359 Mississauga Road North
Mississauga, ON L5L 1C6
Canada
 

 

Contact Information
Office phone: 905-569-4327 
Office: DV 3020B 
Lab: DV 3016B 
Lab phone: 905-569-4752 
Email: ian.orchard@utoronto.ca 
URL: http://www.erin.utoronto.ca/~w3orchar/

 

Research Areas
Animal Biology
Biotechnology
Molecular Biology
Neurobiology
Physiology
Proteomics

 

Research

Current research concerns investigations into aminergic and peptidergic neurons in insects with a view to elucidating the properties underlying integration and regulation of the nervous system. Specific areas of study include the neurobiology of identified peptidergic and aminergic neurons; identification of neuroactive substances and their receptors (GPCRs) using molecular biology, in situ hybridization, and immunohistochemistry; pharmacological properties of receptors; involvement of second messengers in mediating target responses; and the use of this information in the biorational design of pesticides. Systems of particular interest include those associated with feeding and diuresis in Rhodnius prolixus, the vector of Chagas disease in Central and South America.

 

Publications

2015

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Identification and functional characterization of FGLamide-related allatostatin receptor in Rhodnius prolixus.Zandawala M, Orchard I.Insect Biochem. Mol. Biol. 2015 Feb;57:1-10
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2014

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Structure-activity relationships of two Rhodnius prolixus calcitonin-like diuretic hormone analogs.Zandawala M, Poulos C, Orchard I.Peptides 2014 Apr;
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Molecular characterization and possible biological roles of allatotropin in Rhodnius prolixus.Masood M, Orchard I.Peptides 2014 Mar;53:159-71
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The molecular characterization of the kinin transcript and the physiological effects of kinins in the blood-gorging insect, Rhodnius prolixus.Bhatt G, da Silva R, Nachman RJ, Orchard I.Peptides 2014 Mar;53:148-58
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2013

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Isolation and functional characterization of calcitonin-like diuretic hormone receptors in Rhodnius prolixus.Zandawala M, Li S, Hauser F, Grimmelikhuijzen CJ, Orchard I.PLoS ONE 2013;8(11):e82466
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Evidence for a conserved CCAP-signaling pathway controlling ecdysis in a hemimetabolous insect, Rhodnius prolixus.Lee D, Orchard I, Lange AB.Front Neurosci 2013;7:207
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Post-feeding physiology in Rhodnius prolixus: the possible role of FGLamide-related allatostatins.Zandawala M, Orchard I.Gen. Comp. Endocrinol. 2013 Dec;194:311-7
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Expression analysis and molecular characterization of aquaporins in Rhodnius prolixus.Staniscuaski F, Paluzzi JP, Real-Guerra R, Carlini CR, Orchard I.J. Insect Physiol. 2013 Nov;59(11):1140-50
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2012

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The distribution and physiological effects of the myoinhibiting peptides in the kissing bug, rhodnius prolixus.Lange AB, Alim U, Vandersmissen HP, Mizoguchi A, Vanden Broeck J, Orchard I.Front Neurosci 2012;6:98
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Investigation of the potential involvement of eicosanoid metabolites in anti-diuretic hormone signaling in Rhodnius prolixus.Paluzzi JP, Young P, Defferrari MS, Orchard I, Carlini CR, O'Donnell MJ.Peptides 2012 Mar;34(1):127-34
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Cloning of the cDNA, localization, and physiological effects of FGLamide-related allatostatins in the blood-gorging bug, Rhodnius prolixus.Zandawala M, Lytvyn Y, Taiakina D, Orchard I.Insect Biochem. Mol. Biol. 2012 Jan;42(1):10-21
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2011

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The Proctolin Gene and Biological Effects of Proctolin in the Blood-Feeding Bug, Rhodnius prolixus.Orchard I, Lee do H, da Silva R, Lange AB.Front Endocrinol (Lausanne) 2011;2:59
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Identification of the elusive peptidergic diuretic hormone in the blood-feeding bug Rhodnius prolixus: a CRF-related peptide.Te Brugge V, Paluzzi JP, Schooley DA, Orchard I.J. Exp. Biol. 2011 Feb;214(Pt 3):371-81
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Identification of kinin-related peptides in the disease vector, Rhodnius prolixus.Te Brugge V, Paluzzi JP, Neupert S, Nachman RJ, Orchard I.Peptides 2011 Mar;32(3):469-74
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Isolation and characterization of the cDNA encoding DH(31) in the kissing bug, Rhodnius prolixus.Zandawala M, Paluzzi JP, Orchard I.Mol. Cell. Endocrinol. 2011 Jan;331(1):79-88
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2010

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Effects of the mycotoxin destruxin A on Locusta migratoria visceral muscles.Ruiz-Sanchez E, Lange AB, Orchard I.Toxicon 2010 Nov;56(6):1043-51
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Neuropeptide action in insects and crustaceans.Mykles DL, Adams ME, Gäde G, Lange AB, Marco HG, Orchard I.Physiol. Biochem. Zool. 2010 Sep-Oct;83(5):836-46
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Isolation, expression analysis, and functional characterization of the first antidiuretic hormone receptor in insects.Paluzzi JP, Park Y, Nachman RJ, Orchard I.Proc. Natl. Acad. Sci. U.S.A. 2010 Jun;107(22):10290-5
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Effects of the cyclopeptide mycotoxin destruxin A on the Malpighian tubules of Rhodnius prolixus (Stål).Ruiz-Sanchez E, Orchard I, Lange AB.Toxicon 2010 Jun;55(6):1162-70
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The antidiuretic neurohormone RhoprCAPA-2 downregulates fluid transport across the anterior midgut in the blood-feeding insect Rhodnius prolixus.Ianowski JP, Paluzzi JP, Te Brugge VA, Orchard I.Am. J. Physiol. Regul. Integr. Comp. Physiol. 2010 Mar;298(3):R548-57
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A second gene encodes the anti-diuretic hormone in the insect, Rhodnius prolixus.Paluzzi JP, Orchard I.Mol. Cell. Endocrinol. 2010 Apr;317(1-2):53-63
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Neurohormones implicated in the control of Malpighian tubule secretion in plant sucking heteropterans: The stink bugs Acrosternum hilare and Nezara viridula.Coast GM, TeBrugge VA, Nachman RJ, Lopez J, Aldrich JR, Lange A, Orchard I.Peptides 2010 Mar;31(3):468-73
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2009

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Physiological activity of neuropeptide f on the hindgut of the blood-feeding hemipteran, Rhodnius prolixus.Gonzalez R, Orchard I.J. Insect Sci. 2009;9:1-14
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Peptides and serotonin control feeding-related events in Rhodnius prolixus.Orchard I.Front Biosci (Elite Ed) 2009;1:250-62
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Diuretic and antidiuretic hormones in the blood-gorging bug Rhodnius prolixus.Orchard I, Paluzzi JP.Ann. N. Y. Acad. Sci. 2009 Apr;1163:501-3
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Biological activity of diuretic factors on the anterior midgut of the blood-feeding bug, Rhodnius prolixus.Te Brugge V, Ianowski JP, Orchard I.Gen. Comp. Endocrinol. 2009 May;162(1):105-12
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Invitro effect of Canavalia ensiformis urease and the derived peptide Jaburetox-2Ec on Rhodnius prolixus Malpighian tubules.Stanisçuaski F, Te Brugge V, Carlini CR, Orchard I.J. Insect Physiol. 2009 Mar;55(3):255-63
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2008

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Isolation, cloning, and expression mapping of a gene encoding an antidiuretic hormone and other CAPA-related peptides in the disease vector, Rhodnius prolixus.Paluzzi JP, Russell WK, Nachman RJ, Orchard I.Endocrinology 2008 Sep;149(9):4638-46
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Amino acid sequence and biological activity of a calcitonin-like diuretic hormone (DH31) from Rhodnius prolixus.Brugge VA, Schooley DA, Orchard I.J. Exp. Biol. 2008 Feb;211(Pt 3):382-90
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Characterization of neuropeptide F-like immunoreactivity in the blood-feeding hemipteran, Rhodnius prolixus.Gonzalez R, Orchard I.Peptides 2008 Apr;29(4):545-58
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Differential actions of diuretic factors on the Malpighian tubules of Rhodnius prolixus.Donini A, O'Donnell MJ, Orchard I.J. Exp. Biol. 2008 Jan;211(Pt 1):42-8
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2007

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Isolation and sequencing of two FMRFamide-related peptides from the gut of Locusta migratoria L.Hill SR, Orchard I.Peptides 2007 Aug;28(8):1490-7
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Insect neuroendocrinology in the post-genomic era.Nässel D, Orchard I.Gen. Comp. Endocrinol. 2007 Aug-Sep;153(1-3):57-8
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2006

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Distribution, activity and evidence for the release of an anti-diuretic peptide in the kissing bug Rhodnius prolixus.Paluzzi JP, Orchard I.J. Exp. Biol. 2006 Mar;209(Pt 5):907-15
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Serotonin: a coordinator of feeding-related physiological events in the blood-gorging bug, Rhodnius prolixus.Orchard I.Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 2006 Jul;144(3):316-24
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2005

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In vitro analysis of the digestive enzymes amylase and alpha-glucosidase in the midguts of Locusta migratoria L. in response to the myosuppressin, SchistoFLRFamide.Hill SR, Orchard I.J. Insect Physiol. 2005 Jan;51(1):1-9
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The distribution and activity of tachykinin-related peptides in the blood-feeding bug, Rhodnius prolixus.Kwok R, Chung D, Brugge VT, Orchard I.Peptides 2005 Jan;26(1):43-51
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2004

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The effects of dopamine agonists and antagonists on the secretory responses in the salivary glands of the locust (Locusta migratoria).Keating C, Orchard I.J. Insect Physiol. 2004 Jan;50(1):17-23
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The influence of diet and feeding state on FMRFamide-related peptides in the gut of Locusta migratoria L.Hill SR, Orchard I.Peptides 2004 Jan;25(1):105-14
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2003

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The distribution and effects of Dippu-allatostatin-like peptides in the blood-feeding bug, Rhodnius prolixus.Sarkar NR, Tobe SS, Orchard I.Peptides 2003 Oct;24(10):1553-62
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FMRFamide-related peptides in the gut of Locusta migratoria L.: a comprehensive map and developmental profile.Hill SR, Orchard I.Peptides 2003 Oct;24(10):1511-24
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2002

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Central effects of the peptides, SchistoFLRFamide and proctolin, on locust oviduct contraction.Kwok R, Orchard I.Peptides 2002 Nov;23(11):1925-32
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Characterization of a putative SchistoFLRFamide receptor in the CNS of Locusta migratoria.Kwok R, Orchard I.Peptides 2002 Apr;23(4):765-72
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Contractions associated with the salivary glands of the blood-feeding bug, Rhodnius prolixus: evidence for both a neural and neurohormonal coordination.Orchard I, Brugge VT.Peptides 2002 Apr;23(4):693-700
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