Linda Kohn

faculty_img Academic Title: Professor

Campus: UTM

CSB Appointment: Cross Appointment

Primary Undergraduate Department:
Biology, UTM

Graduate Programs:
Cell & Systems Biology

Titles and Honors:
Fellow of the American Association for the Advancement of Science

Academic or Administrative Appointments:


Education:
Ph.D. Cornell University 1979
B.Sc. University of Vermont 1973

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
3359 Mississauga Road North
Mississauga, ON L5L 1C6
Canada
 

 

Contact Information
Office phone: 905-828-3997 
Office: DV 3047 
Lab: DV 4090C 
Lab phone: 905-828-5338 
Email: linda.kohn@utoronto.ca  
URL: http://www.erin.utoronto.ca/~w3bio/faculty_and_research/kohn.htm

 

Research Areas
Comparative Genomics
Evolutionary Biology
Plant Biology

 

Research

I am a mycologist; my specialty is the ascomycetes. I am an avid observer of the field natural history of fungi, the foundation of my undergraduate teaching (BIO 335) as well as much of my research. I am currently working on: Mechanisms of speciation in fungi. I continue to infer patterns of population divergence and speciation through retrospective studies based on population samples. This includes both agricultural plant pathogens and “wild” fungi. The new part is that, in collaboration with Jim Anderson, we are observing incipient speciation in experimental populations of both yeast and filamentous fungi. Fungal model systems are ideal for getting at genetics and genomics of this trajectory of adaptation, divergence and reproductive isolation – and for addressing key questions in speciation theory. Mechanisms of trophic preference in pathogenic fungi. New projects use genomic resources for Sclerotinia, Botrytis, and other fungi as a starting point for molecular and genetic investigation of the evolutionary divergence of trophic type among closely related taxa. Population and community dynamics of fungi in plants. This is a shift in scale to patterns and processes of fungi in planta. Current projects include lab and field experiments on facilitation /competition among maize endophytes associated with fungal tolerance of a maize allelopathic compound.

 

Publications

2014

Top
The Underlying Structure of Adaptation Under Strong Selection in Twelve Experimental Yeast Populations.Kohn LM, Anderson JB.Eukaryotic Cell 2014 Jul;
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2012

Top
PRP8 inteins in species of the genus Botrytis and other ascomycetes.Bokor AA, Kohn LM, Poulter RT, van Kan JA.Fungal Genet. Biol. 2012 Mar;49(3):250-61
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Evidence for a common toolbox based on necrotrophy in a fungal lineage spanning necrotrophs, biotrophs, endophytes, host generalists and specialists.Andrew M, Barua R, Short SM, Kohn LM.PLoS ONE 2012;7(1):e29943
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2011

Top
Cellular effects and epistasis among three determinants of adaptation in experimental populations of Saccharomyces cerevisiae.Parreiras LS, Kohn LM, Anderson JB.Eukaryotic Cell 2011 Oct;10(10):1348-56
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2010

Top
Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populations.Anderson JB, Funt J, Thompson DA, Prabhu S, Socha A, Sirjusingh C, Dettman JR, Parreiras L, Guttman DS, Regev A, Kohn LM.Curr. Biol. 2010 Aug;20(15):1383-8
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Genome-wide investigation of reproductive isolation in experimental lineages and natural species of Neurospora: identifying candidate regions by microarray-based genotyping and mapping.Dettman JR, Anderson JB, Kohn LM.Evolution 2010 Mar;64(3):694-709
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2009

Top
Single nucleotide polymorphism-based diagnostic system for crop-associated Sclerotinia species.Andrew M, Kohn LM.Appl. Environ. Microbiol. 2009 Sep;75(17):5600-6
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Evidence for alteration of fungal endophyte community assembly by host defense compounds.Saunders M, Kohn LM.New Phytol. 2009;182(1):229-38
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2008

Top
Divergent adaptation promotes reproductive isolation among experimental populations of the filamentous fungus Neurospora.Dettman JR, Anderson JB, Kohn LM.BMC Evol. Biol. 2008;8:35
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Marker stability throughout 400 days of in vitro hyphal growth in the filamentous ascomycete, Sclerotinia sclerotiorum.Kohn LM, Schaffer MR, Anderson JB, Grünwald NJ.Fungal Genet. Biol. 2008 May;45(5):613-7
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Host-synthesized secondary compounds influence the in vitro interactions between fungal endophytes of maize.Saunders M, Kohn LM.Appl. Environ. Microbiol. 2008 Jan;74(1):136-42
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2007

Top
New Populations of Sclerotinia sclerotiorum from Lettuce in California and Peas and Lentils in Washington.Malvárez G, Carbone I, Grünwald NJ, Subbarao KV, Schafer M, Kohn LM.Phytopathology 2007 Apr;97(4):470-83
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Incipient speciation by divergent adaptation and antagonistic epistasis in yeast.Dettman JR, Sirjusingh C, Kohn LM, Anderson JB.Nature 2007 May;447(7144):585-8
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2006

Top
An optimized method for mycelial compatibility testing in Sclerotinia sclerotiorum.Schafer MR, Kohn LM.Mycologia 2006 Jul-Aug;98(4):593-7
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2005

Top
Mechanisms of fungal speciation.Kohn LM.Annu Rev Phytopathol 2005;43:279-308
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Origins of host-specific populations of the blast pathogen Magnaporthe oryzae in crop domestication with subsequent expansion of pandemic clones on rice and weeds of rice.Couch BC, Fudal I, Lebrun MH, Tharreau D, Valent B, van Kim P, Nottéghem JL, Kohn LM.Genetics 2005 Jun;170(2):613-30
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2003

Top
Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae.Anderson JB, Sirjusingh C, Parsons AB, Boone C, Wickens C, Cowen LE, Kohn LM.Genetics 2003 Apr;163(4):1287-98
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2002

Top
A multilocus gene genealogy concordant with host preference indicates segregation of a new species, Magnaporthe oryzae, from M. grisea.Couch BC, Kohn LM.Mycologia 2002 Jul-Aug;94(4):683-93
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Evolution of drug resistance in Candida albicans.Cowen LE, Anderson JB, Kohn LM.Annu. Rev. Microbiol. 2002;56:139-65
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Population genomics of drug resistance in Candida albicans.Cowen LE, Nantel A, Whiteway MS, Thomas DY, Tessier DC, Kohn LM, Anderson JB.Proc. Natl. Acad. Sci. U.S.A. 2002 Jul;99(14):9284-9
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