Loren Martin

faculty_img Academic Title: Assistant Professor

Campus: UTM

CSB Appointment: Cross Appointment

Primary Undergraduate Department:
Psychology

Graduate Programs:
Psychology
Cell & Systems Biology
Neuroscience

Titles and Honors
Academic or Administrative Appointments
Education
Ph.D., University of Toronto, 2009

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
3359 Mississauga Road North
Mississauga, ON L5L 1C6
Canada

 

Contact Information
Office phone: 905-569-5784
Office: CCT 4061
Lab: DV 1076
Lab phone: 905-828-3785
Email: lj.martin@utoronto.ca
URL: http://www.utmpainlab.ca

 

Research Areas
Animal Biology
Cell Biology
Psychology & Behavior
Molecular Biology

 

 

Research

Chronic pain is a maladaptive state that alters nervous system functioning. This results in aberrant and excitable neural networks that manifest in the form of spontaneous pain and the amplification of noxious and innocuous stimuli. Chronic pain modulates and is modulated by cognitive, emotional and mental states including attention, fear and stress. A large focus of my research is to understand the bidirectional interplay between stress and pain. If a person (or mouse) is stressed, simply put, the brain’s ability to filter pain signals is affected in a bad way and pain can be amplified. Each one (pain and stress) can have an impact on the other, creating a vicious cycle that sets the stage for chronic pain and chronic stress. Additionally, we find that processes such as empathy are negatively affected (in mice and humans) by increased social stress and another aspect of my research aims to dissect the underlying biological mechanisms of empathy and prosocial behaviours (using both animal and human subjects). Finally, I am also interested the negative effects that pain has on cognition (learning, memory, brain plasticity) and social interactions when pain is experienced or starts during different developmental time points (neonatal, adolescence, adulthood).

 

Publications

2015

Top
Different immune cells mediate mechanical pain hypersensitivity in male and female mice.Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin JS, Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, Tu Y, Klip A, Ji RR, Zhang J, Salter MW, Mogil JS.Nat. Neurosci. 2015 Aug;18(8):1081-3
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Molecular genetic mechanisms of allelic specific regulation of murine Comt expression.Segall SK, Shabalina SA, Meloto CB, Wen X, Cunningham D, Tarantino LM, Wiltshire T, Gauthier J, Tohyama S, Martin LJ, Mogil JS, Diatchenko L.Pain 2015 Oct;156(10):1965-77
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The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.Wieskopf JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin JS, Dai F, Zhang J, Marcovitz J, Tuttle AH, Slepian PM, Clarke S, Drenan RM, Janes J, Al Sharari S, Segall SK, Aasvang EK, Lai W, Bittner R, Richards CI, Slade GD, Kehlet H, Walker J, Maskos U, Changeux JP, Devor M, Maixner W, Diatchenko L, Belfer I, Dougherty DA, Su AI, Lummis SC, Imad Damaj M, Lester HA, Patapoutian A, Mogil JS.Sci Transl Med 2015 May;7(287):287ra72
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Reducing social stress elicits emotional contagion of pain in mouse and human strangers.Martin LJ, Hathaway G, Isbester K, Mirali S, Acland EL, Niederstrasser N, Slepian PM, Trost Z, Bartz JA, Sapolsky RM, Sternberg WF, Levitin DJ, Mogil JS.Curr. Biol. 2015 Feb;25(3):326-32
pubmed

2014

Top
Olfactory exposure to males, including men, causes stress and related analgesia in rodents.Sorge RE, Martin LJ, Isbester KA, Sotocinal SG, Rosen S, Tuttle AH, Wieskopf JS, Acland EL, Dokova A, Kadoura B, Leger P, Mapplebeck JC, McPhail M, Delaney A, Wigerblad G, Schumann AP, Quinn T, Frasnelli J, Svensson CI, Sternberg WF, Mogil JS.Nat. Methods 2014 Jun;11(6):629-32
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The interaction between pain and social behavior in humans and rodents.Martin LJ, Tuttle AH, Mogil JS.Curr Top Behav Neurosci 2014;20:233-50
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2013

Top
Acutely increasing δGABA(A) receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus.Whissell PD, Eng D, Lecker I, Martin LJ, Wang DS, Orser BA.Front Neural Circuits 2013;7:146
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2011

Top
The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions.Sotocinal SG, Sorge RE, Zaloum A, Tuttle AH, Martin LJ, Wieskopf JS, Mapplebeck JC, Wei P, Zhan S, Zhang S, McDougall JJ, King OD, Mogil JS.Mol Pain 2011;7:55
pubmed
The sedative but not the memory-blocking properties of ethanol are modulated by α5-subunit-containing γ-aminobutyric acid type A receptors.Martin LJ, Zurek AA, Bonin RP, Oh GH, Kim JH, Mount HT, Orser BA.Behav. Brain Res. 2011 Mar;217(2):379-85
pubmed

2010

Top
Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptor inverse agonist L-655,708.Saab BJ, Maclean AJ, Kanisek M, Zurek AA, Martin LJ, Roder JC, Orser BA.Anesthesiology 2010 Nov;113(5):1061-71
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Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory.Martin LJ, Zurek AA, MacDonald JF, Roder JC, Jackson MF, Orser BA.J. Neurosci. 2010 Apr;30(15):5269-82
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alpha5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation.Vargas-Caballero M, Martin LJ, Salter MW, Orser BA, Paulsen O.Neuropharmacology 2010 Mar;58(3):668-75
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2009

Top
The physiological properties and therapeutic potential of alpha5-GABAA receptors.Martin LJ, Bonin RP, Orser BA.Biochem. Soc. Trans. 2009 Dec;37(Pt 6):1334-7
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Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade.Martin LJ, Oh GH, Orser BA.Anesthesiology 2009 Nov;111(5):1025-35
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Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia.Sun HS, Jackson MF, Martin LJ, Jansen K, Teves L, Cui H, Kiyonaka S, Mori Y, Jones M, Forder JP, Golde TE, Orser BA, Macdonald JF, Tymianski M.Nat. Neurosci. 2009 Oct;12(10):1300-7
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2007

Top
Alpha5GABAA receptors regulate the intrinsic excitability of mouse hippocampal pyramidal neurons.Bonin RP, Martin LJ, MacDonald JF, Orser BA.J. Neurophysiol. 2007 Oct;98(4):2244-54
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2006

Top
Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate.Cheng VY, Martin LJ, Elliott EM, Kim JH, Mount HT, Taverna FA, Roder JC, Macdonald JF, Bhambri A, Collinson N, Wafford KA, Orser BA.J. Neurosci. 2006 Apr;26(14):3713-20
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2005

Top
Modulation of NMDA receptors by pituitary adenylate cyclase activating peptide in CA1 neurons requires G alpha q, protein kinase C, and activation of Src.Macdonald DS, Weerapura M, Beazely MA, Martin L, Czerwinski W, Roder JC, Orser BA, MacDonald JF.J. Neurosci. 2005 Dec;25(49):11374-84
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2004

Top
Alpha2-adrenergic inhibition prevents the accompanied anticonvulsant effect of swim stress on behavioral convulsions induced by lithium and pilocarpine.Galic MA, Fournier NM, Martin LJ.Pharmacol. Biochem. Behav. 2004 Oct;79(2):309-16
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Influence of a complex magnetic field application in rats upon thermal nociceptive thresholds: the importance of polarity and timing.Martin LJ, Koren SA, Persinger MA.Int. J. Neurosci. 2004 Oct;114(10):1259-76
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Thermal analgesia induced by 30-min exposure to 1 microT burst-firing magnetic fields is strongly enhanced in a dose-dependent manner by the alpha2 agonist clonidine in rats.Martin LJ, Persinger MA.Neurosci. Lett. 2004 Aug;366(2):226-9
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Thermal analgesic effects from weak, complex magnetic fields and pharmacological interactions.Martin LJ, Koren SA, Persinger MA.Pharmacol. Biochem. Behav. 2004 Jun;78(2):217-27
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Chronic administration of the L-type calcium channel blocker nimodipine can facilitate the acquisition of sequence learning in a radial-arm maze.Martin LJ, Fournier NM, Galic MA, Emond MH.Behav Pharmacol 2004 Mar;15(2):133-9
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2003

Top
Spatial heterogeneity not homogeneity of the magnetic field during exposures to complex frequency-modulated patterns facilitates analgesia.Martin LJ, Persinger MA.Percept Mot Skills 2003 Jun;96(3 Pt 1):1005-12
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2002

Top
Learning and memory in agmatine-treated rats.McKay BE, Lado WE, Martin LJ, Galic MA, Fournier NM.Pharmacol. Biochem. Behav. 2002 Jun;72(3):551-7
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