|1265 Military Trail, Science Wing, Room SW533 Toronto, ON M1C 1A4 Canada|
|Office phone: 416-208-8130
Lab phone: 416-946-7238
|Early life experiences crucially define cognitive and mental health function throughout life. Childhood and adolescence are the predominant age of onset for the majority of mental disorders and are periods during which key brain areas involved in emotional processing are maturing. Still, it is unclear how these changes in brain development influence circuit function and as a consequence affect behaviour and the onset of mental illness. Our research focuses on understanding how the maturation of sensitive brain circuits underlies the emergence of complex behaviour and sensitivity to stress in mice. We are exploring this using a combination of patch clamp recordings, immunohistochemistry, behaviour, and in vitro and in vivo optogenetics.
Our lab uses a systems level approach to explore the relationship between the maturation of sensitive brain circuits, the emergence of complex behaviour, and stress sensitivity in mice.
Arruda-Carvalho M, Clem RL. Prefrontal-amygdala fear networks come into focus.
Front Syst Neurosci 9:145, 2015.
Arruda-Carvalho M, Clem RL. Pathway-selective adjustment of prefrontal-amygdala transmission during fear encoding.
Journal of Neuroscience 34(47):15601-9, 2014
Arruda-Carvalho M, Akers KG, Guskjolen A, Sakaguchi M, Josselyn SA, Frankland PW. Post-training ablation of adult-generated olfactory granule cells degrades odor-reward memories.
Journal of Neuroscience 34(47):15793-803, 2014
Arruda-Carvalho M, Restivo L, Guskjolen A, Epp JR, Elgersma Y, Josselyn SA, Frankland PW. Conditional Deletion of α-CaMKII Impairs Integration of Adult-Generated Granule Cells into Dentate Gyrus Circuits and Hippocampus-Dependent Learning.
Journal of Neuroscience 34(36): 11919-28 (2014)
Akers KG, Arruda-Carvalho M, Josselyn SA, Frankland PW. Ontogeny of contextual fear memory formation, specificity, and persistence in mice.
Learning & Memory. 19(12):598-604 (2012).
Gu Y, Arruda-Carvalho M, Wang J, Janoschka S, Josselyn SA, Frankland PW, Ge S. Optical controlling reveals time-dependent roles for adult-born dentate granule cells.
Nature Neuroscience 15(12):1700-6. (2012)
Arruda-Carvalho M, Sakaguchi M, Akers KG, Josselyn SA, Frankland PW. Posttraining ablation of adult-generated neurons degrades previously acquired memories.
Journal of Neuroscience 31(42):15113-27(2011)
Comment in Nature 478 (7370) 431.
Sakaguchi M, Arruda-Carvalho M, Kang NH, Imaizumi Y, Poirier F, Okano H, Frankland PW. Impaired spatial and contextual memory formation in galectin-1 deficient mice.
Molecular Brain. 4(1):33 (2011)
Leslie AT, Akers KG, Krakowski AD, Stone SSD, Sakaguchi M, Arruda-Carvalho M, Frankland PW. Impact of early adverse experience on complexity of adult-generated neurons.
Translational Psychiatry 1, e35 (2011)
Ribas VT, Arruda-Carvalho M, Linden R, Chiarini LB. Early c-Jun N-terminal kinase-dependent phosphorylation of activating transcription factor-2 is associated with degeneration of retinal ganglion cells.
Neuroscience 180:64-74 (2011)
Akers KG, Sakaguchi M, Arruda-Carvalho M. Functional contribution of adult-generated olfactory bulb interneurons: odor discrimination versus odor memory.
Journal of Neuroscience 30(13):4523-5 (2010)
Frankland PW, Sakaguchi M, Arruda-Carvalho M. Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?
Molecular Brain. 1(1):5 (2008)
Arruda-Carvalho M, Njaine B, Silveira MS, Linden R, Chiarini LB. Hop/STI1 modulates retinal proliferation and cell death independent of PrPC. Biochem Biophys Res Commun. 361(2):474-80 (2007)