Malcolm Campbell

faculty_img Academic Title: Professor

Campus: UTSC

CSB Appointment: Full

Primary Undergraduate Department:
Biological Sciences, UTSC

Graduate Programs:
Cell & Systems Biology
Developmental Biology
Ecology & Evolutionary Biology
Forestry
Genome Biology & Bioinformatics

Titles and Honors:


Academic or Administrative Appointments:
Vice-Principal Research, UTSC

Education:
MA (Oxon) University of Oxford 1996
PhD University of Guelph 1991
BSc University of Guelph 1986

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4
Canada
 

 

Contact Information
Office phone: 416-208-4835 
Office: AA 439 
Lab:  
Lab phone:  
Email: malcolm.campbell@utoronto.ca 
URL: http://bit.ly/xwsyBJ

 

Research Areas
Biotechnology
Cell Biology
Developmental Biology
Functional Genomics
Genetics
Molecular Biology
Plant Biology
Systems Biology

 

Research

As they are literally rooted in place, plants possess remarkable mechanisms that perceive, interpret, and respond to internal and external cues so as to optimise plant growth & development relative to prevailing environment conditions. Despite the incredible diversity in plant forms, the molecular mechanisms that control plant responses to internal and external cues are highly conserved across diverse genera. The timing and localisation of these mechanisms shape plant & development. Our research team aims to gain greater insights into molecular mechanisms that plants employ to convert internal cues and external signals into appropriate adjustments in resource acquisition and allocation, focusing on the role of gene regulation in conditioning these adjustments. Toward this end, we test hypotheses related to the roles of small-molecule signaling, transcription factor function, epigenome modification, transcriptome remodeling, and transcriptional networks in conditioning plant responses to internal and external cues. We test hypotheses using comparative functional genomics / epigenomics approaches, bridging basic plant biology conducted with the model species A. thaliana to the economically and ecologically important genus Populus. Our research builds on experience in dissection of plant perception of sugars and water, reconfiguration of gene expression, and modification of plant function.

 

Publications

2013

Top
Investigating the drought-stress response of hybrid poplar genotypes by metabolite profiling.Barchet GL, Dauwe R, Guy RD, Schroeder WR, Soolanayakanahally RY, Campbell MM, Mansfield SD.Tree Physiol. 2013 Oct;
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Interactions between the R2R3-MYB transcription factor, AtMYB61, and target DNA binding sites.Prouse MB, Campbell MM.PLoS ONE 2013;8(5):e65132
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Interplay between sucrose and folate modulates auxin signaling in Arabidopsis.Stokes ME, Chattopadhyay A, Wilkins O, Nambara E, Campbell MM.Plant Physiol. 2013 Jul;162(3):1552-65
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Epigenetic regulation of adaptive responses of forest tree species to the environment.Bräutigam K, Vining KJ, Lafon-Placette C, Fossdal CG, Mirouze M, Marcos JG, Fluch S, Fraga MF, Guevara MÁ, Abarca D, Johnsen O, Maury S, Strauss SH, Campbell MM, Rohde A, Díaz-Sala C, Cervera MT.Ecol Evol 2013 Feb;3(2):399-415
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2012

Top
Constitutive expression of a fungal glucuronoyl esterase in Arabidopsis reveals altered cell wall composition and structure.Tsai AY, Canam T, Gorzsás A, Mellerowicz EJ, Campbell MM, Master ER.Plant Biotechnol. J. 2012 Dec;10(9):1077-87
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Drought induces alterations in the stomatal development program in Populus.Hamanishi ET, Thomas BR, Campbell MM.J. Exp. Bot. 2012 Aug;63(13):4959-71
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AtMYB61, an R2R3-MYB transcription factor, functions as a pleiotropic regulator via a small gene network.Romano JM, Dubos C, Prouse MB, Wilkins O, Hong H, Poole M, Kang KY, Li E, Douglas CJ, Western TL, Mansfield SD, Campbell MM.New Phytol. 2012 Sep;195(4):774-86
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The interaction between MYB proteins and their target DNA binding sites.Prouse MB, Campbell MM.Biochim. Biophys. Acta 2012 Jan;1819(1):67-77
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2011

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Clone history shapes Populus drought responses.Raj S, Bräutigam K, Hamanishi ET, Wilkins O, Thomas BR, Schroeder W, Mansfield SD, Plant AL, Campbell MM.Proc. Natl. Acad. Sci. U.S.A. 2011 Jul;108(30):12521-6
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PlaNet: combined sequence and expression comparisons across plant networks derived from seven species.Mutwil M, Klie S, Tohge T, Giorgi FM, Wilkins O, Campbell MM, Fernie AR, Usadel B, Nikoloski Z, Persson S.Plant Cell 2011 Mar;23(3):895-910
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Transcriptomic responses of the softwood-degrading white-rot fungus Phanerochaete carnosa during growth on coniferous and deciduous wood.MacDonald J, Doering M, Canam T, Gong Y, Guttman DS, Campbell MM, Master ER.Appl. Environ. Microbiol. 2011 May;77(10):3211-8
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2010

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Endogenous overexpression of Populus MYB186 increases trichome density, improves insect pest resistance, and impacts plant growth.Plett JM, Wilkins O, Campbell MM, Ralph SG, Regan S.Plant J. 2010 Nov;64(3):419-32
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Genome-wide analysis of plant metal transporters, with an emphasis on poplar.Migeon A, Blaudez D, Wilkins O, Montanini B, Campbell MM, Richaud P, Thomine S, Chalot M.Cell. Mol. Life Sci. 2010 Nov;67(22):3763-84
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Time of day shapes Arabidopsis drought transcriptomes.Wilkins O, Bräutigam K, Campbell MM.Plant J. 2010 Sep;63(5):715-27
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Intraspecific variation in the Populus balsamifera drought transcriptome.Hamanishi ET, Raj S, Wilkins O, Thomas BR, Mansfield SD, Plant AL, Campbell MM.Plant Cell Environ. 2010 Oct;33(10):1742-55
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2009

Top
Genotype and time of day shape the Populus drought response.Wilkins O, Waldron L, Nahal H, Provart NJ, Campbell MM.Plant J. 2009 Nov;60(4):703-15
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Genes and nitrogen fuel wood formation.Canam T, Campbell MM.New Phytol. 2009 Jun;182(4):783-5
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Post-translational modification of an R2R3-MYB transcription factor by a MAP Kinase during xylem development.Morse AM, Whetten RW, Dubos C, Campbell MM.New Phytol. 2009;183(4):1001-13
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The wound-, pathogen-, and ultraviolet B-responsive MYB134 gene encodes an R2R3 MYB transcription factor that regulates proanthocyanidin synthesis in poplar.Mellway RD, Tran LT, Prouse MB, Campbell MM, Constabel CP.Plant Physiol. 2009 Jun;150(2):924-41
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Expansion and diversification of the Populus R2R3-MYB family of transcription factors.Wilkins O, Nahal H, Foong J, Provart NJ, Campbell MM.Plant Physiol. 2009 Feb;149(2):981-93
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2006

Top
Varied growth, biomass and cellulose content in tobacco expressing yeast-derived invertases.Canam T, Park JY, Yu KY, Campbell MM, Ellis DD, Mansfield SD.Planta 2006 Nov;224(6):1315-27
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2005

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Comparison of lignin deposition in three ectopic lignification mutants.Rogers LA, Dubos C, Surman C, Willment J, Cullis IF, Mansfield SD, Campbell MM.New Phytol. 2005 Oct;168(1):123-40
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Kanamycin reveals the role played by glutamate receptors in shaping plant resource allocation.Dubos C, Willment J, Huggins D, Grant GH, Campbell MM.Plant J. 2005 Aug;43(3):348-55
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AtMYB61, an R2R3-MYB transcription factor controlling stomatal aperture in Arabidopsis thaliana.Liang YK, Dubos C, Dodd IC, Holroyd GH, Hetherington AM, Campbell MM.Curr. Biol. 2005 Jul;15(13):1201-6
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Constitutively high expression of the histidine biosynthetic pathway contributes to nickel tolerance in hyperaccumulator plants.Ingle RA, Mugford ST, Rees JD, Campbell MM, Smith JA.Plant Cell 2005 Jul;17(7):2089-106
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Light, the circadian clock, and sugar perception in the control of lignin biosynthesis.Rogers LA, Dubos C, Cullis IF, Surman C, Poole M, Willment J, Mansfield SD, Campbell MM.J. Exp. Bot. 2005 Jun;56(416):1651-63
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2004

Top
Functional interactions between a glutamine synthetase promoter and MYB proteins.Gómez-Maldonado J, Avila C, Torre F, Cañas R, Cánovas FM, Campbell MM.Plant J. 2004 Aug;39(4):513-26
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Involvement of the R2R3-MYB, AtMYB61, in the ectopic lignification and dark-photomorphogenic components of the det3 mutant phenotype.Newman LJ, Perazza DE, Juda L, Campbell MM.Plant J. 2004 Jan;37(2):239-50
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2003

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Forestry's fertile crescent: the application of biotechnology to forest trees.Campbell MM, Brunner AM, Jones HM, Strauss SH.Plant Biotechnol. J. 2003 May;1(3):141-54
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Characterisation of Pt MYB1, an R2R3-MYB from pine xylem.Patzlaff A, Newman LJ, Dubos C, Whetten RW, Smith C, McInnis S, Bevan MW, Sederoff RR, Campbell MM.Plant Mol. Biol. 2003 Nov;53(4):597-608
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Characterisation of a pine MYB that regulates lignification.Patzlaff A, McInnis S, Courtenay A, Surman C, Newman LJ, Smith C, Bevan MW, Mansfield S, Whetten RW, Sederoff RR, Campbell MM.Plant J. 2003 Dec;36(6):743-54
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A role for glycine in the gating of plant NMDA-like receptors.Dubos C, Huggins D, Grant GH, Knight MR, Campbell MM.Plant J. 2003 Sep;35(6):800-10
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1998

Top
Partially Modified Retro-Inverso Peptides: Development, Synthesis, and Conformational Behavior.Fletcher MD, Campbell MM.Chem. Rev. 1998 Apr;98(2):763-796
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