Marla Sokolowski

faculty_img Academic Title: Professor

Campus: St. George

CSB Appointment: Cross Appointment

Primary Undergraduate Department:
Ecology & Evolutionary Biology

Graduate Programs:
Cell & Systems Biology
Ecology & Evolutionary Biology

Titles and Honors:
University Professor
Fellow of the Royal Society of Canada
Canada Research Chair in Genetics and Behavioural Neurlogy
Senior Fellow of the Canadian Institute for Advanced Research

Academic or Administrative Appointments:
Academic Director of the Fraser Mustard Institute for Human Development
Co director of the Child and Brain Development Program of the Canadian Institute for Advanced Research

Education:
Ph.D. University of Toronto 1981
B.Sc. University of Toronto 1973

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
25 Willcocks St.
Toronto, ON M5S 3B2
Canada
 

 

Contact Information
Office phone: 416-978-8501 
Office: ESC 3040 
Lab: ESC 2065/RW 508 
Lab phone: 416-978-3139 
Email: marla.sokolowski@utoronto.ca 
URL: http://www.erin.utoronto.ca/~w3forage/

 

Research Areas

 

Research

Prof Sokolowski has trail-blazed the development of a branch of Behaviour Genetics that addresses the genetic, molecular, environmental underpinnings of natural individual differences in behaviour and is best known for her discovery of the foraging gene. Her award winning innovative work is esteemed worldwide as a clear, integrative mechanistic paragon of the manner in which genes interact with the environment and impact behaviour.

 

Publications

2014

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Gene-environment interplay in Drosophila melanogaster: Chronic nutritional deprivation in larval life affects adult fecal output.Urquhart-Cronish M, Sokolowski MB.J. Insect Physiol. 2014 Jun;
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Na+/K+-ATPase trafficking induced by heat shock pretreatment correlates with increased resistance to anoxia in locusts.Hou N, Armstrong GA, Chakraborty-Chatterjee M, Sokolowski MB, Robertson RM.J. Neurophysiol. 2014 May;
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Association between the seven-repeat allele of the dopamine-4 receptor gene (DRD4) and spontaneous food intake in pre-school children.Silveira PP, Portella AK, Kennedy JL, Gaudreau H, Davis C, Steiner M, Soares CN, Matthews SG, Sokolowski MB, Dubé L, Loucks EB, Hamilton J, Meaney MJ, Levitan RD, .Appetite 2014 Feb;73:15-22
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2013

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Social environment influences performance in a cognitive task in natural variants of the foraging gene.Kohn NR, Reaume CJ, Moreno C, Burns JG, Sokolowski MB, Mery F.PLoS ONE 2013;8(12):e81272
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The effects of parity and maternal behavior on gene expression in the medial preoptic area and the medial amygdala in postpartum and virgin female rats: A microarray study.Akbari EM, Shams S, Belay HT, Kaiguo M, Razak Z, Kent CF, Westwood T, Sokolowski MB, Fleming AS.Behav. Neurosci. 2013 Dec;127(6):913-22
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Interaction between oxytocin genotypes and early experience predicts quality of mothering and postpartum mood.Mileva-Seitz V, Steiner M, Atkinson L, Meaney MJ, Levitan R, Kennedy JL, Sokolowski MB, Fleming AS.PLoS ONE 2013;8(4):e61443
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2012

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A genetic screen for olfactory habituation mutations in Drosophila: analysis of novel foraging alleles and an underlying neural circuit.Eddison M, Belay AT, Sokolowski MB, Heberlein U.PLoS ONE 2012;7(12):e51684
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Toward a new biology of social adversity.Boyce WT, Sokolowski MB, Robinson GE.Proc. Natl. Acad. Sci. U.S.A. 2012 Oct;109 Suppl 2:17143-8
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Gene-environment interplay in Drosophila melanogaster: chronic food deprivation in early life affects adult exploratory and fitness traits.Burns JG, Svetec N, Rowe L, Mery F, Dolan MJ, Boyce WT, Sokolowski MB.Proc. Natl. Acad. Sci. U.S.A. 2012 Oct;109 Suppl 2:17239-44
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Advances in Genetics. Preface.Sokolowski MB, Goodwin SF.Adv. Genet. 2012;77:ix-x
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The visual orientation memory of Drosophila requires Foraging (PKG) upstream of Ignorant (RSK2) in ring neurons of the central complex.Kuntz S, Poeck B, Sokolowski MB, Strauss R.Learn. Mem. 2012;19(8):337-40
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Foraging alters resilience/vulnerability to sleep disruption and starvation in Drosophila.Donlea J, Leahy A, Thimgan MS, Suzuki Y, Hughson BN, Sokolowski MB, Shaw PJ.Proc. Natl. Acad. Sci. U.S.A. 2012 Feb;109(7):2613-8
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2011

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Conservation of gene function in behaviour.Reaume CJ, Sokolowski MB.Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2011 Jul;366(1574):2100-10
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Epigenetic regulation of learning and memory by Drosophila EHMT/G9a.Kramer JM, Kochinke K, Oortveld MA, Marks H, Kramer D, de Jong EK, Asztalos Z, Westwood JT, Stunnenberg HG, Sokolowski MB, Keleman K, Zhou H, van Bokhoven H, Schenck A.PLoS Biol. 2011;9(1):e1000569
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A natural genetic polymorphism affects retroactive interference in Drosophila melanogaster.Reaume CJ, Sokolowski MB, Mery F.Proc. Biol. Sci. 2011 Jan;278(1702):91-8
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2010

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Quantitative trait locus mapping of gravitaxis behaviour in Drosophila melanogaster.Desroches CE, Busto M, Riedl CA, Mackay TF, Sokolowski MB.Genet Res (Camb) 2010 Jun;92(3):167-74
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Job switching in ants: Role of a kinase.Lucas C, Hughson BN, Sokolowski MB.Commun Integr Biol 2010 Jan;3(1):6-8
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Genotype-by-diet interactions drive metabolic phenotype variation in Drosophila melanogaster.Reed LK, Williams S, Springston M, Brown J, Freeman K, DesRoches CE, Sokolowski MB, Gibson G.Genetics 2010 Jul;185(3):1009-19
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Social interactions in "simple" model systems.Sokolowski MB.Neuron 2010 Mar;65(6):780-94
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2009

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Socio-genetics. Preface.Sokolowski MB.Adv. Genet. 2009;68:ix-x
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The Drosophila foraging gene mediates adult plasticity and gene-environment interactions in behaviour, metabolites, and gene expression in response to food deprivation.Kent CF, Daskalchuk T, Cook L, Sokolowski MB, Greenspan RJ.PLoS Genet. 2009 Aug;5(8):e1000609
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Molecular basis for changes in behavioral state in ant social behaviors.Lucas C, Sokolowski MB.Proc. Natl. Acad. Sci. U.S.A. 2009 Apr;106(15):6351-6
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Evolution: how fruit flies adapt to seasonal stresses.Williams KD, Sokolowski MB.Curr. Biol. 2009 Jan;19(2):R63-4
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cGMP-dependent protein kinase: linking foraging to energy homeostasis.Kaun KR, Sokolowski MB.Genome 2009 Jan;52(1):1-7
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cGMP-dependent protein kinase as a modifier of behaviour.Reaume CJ, Sokolowski MB.Handb Exp Pharmacol 2009;(191):423-43
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2008

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Marla Sokolowski.Sokolowski MB.Curr. Biol. 2008 Dec;18(24):R1116-7
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Natural variation in plasticity of glucose homeostasis and food intake.Kaun KR, Chakaborty-Chatterjee M, Sokolowski MB.J. Exp. Biol. 2008 Oct;211(Pt 19):3160-6
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Behavioural genetics: worms seek that old beetle smell.Sokolowski MB, Fitzpatrick MJ.Curr. Biol. 2008 Jun;18(11):R480-2
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2007

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Genetic and behavioral analysis of natural variation in Drosophila melanogaster pupation position.Riedl CA, Riedl M, Mackay TF, Sokolowski MB.Fly (Austin) 2007 Jan-Feb;1(1):23-32
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Natural variation in food acquisition mediated via a Drosophila cGMP-dependent protein kinase.Kaun KR, Riedl CA, Chakaborty-Chatterjee M, Belay AT, Douglas SJ, Gibbs AG, Sokolowski MB.J. Exp. Biol. 2007 Oct;210(Pt 20):3547-58
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Natural variation in the thermotolerance of neural function and behavior due to a cGMP-dependent protein kinase.Dawson-Scully K, Armstrong GA, Kent C, Robertson RM, Sokolowski MB.PLoS ONE 2007;2(8):e773
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Natural polymorphism affecting learning and memory in Drosophila.Mery F, Belay AT, So AK, Sokolowski MB, Kawecki TJ.Proc. Natl. Acad. Sci. U.S.A. 2007 Aug;104(32):13051-5
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Natural variation in Drosophila larval reward learning and memory due to a cGMP-dependent protein kinase.Kaun KR, Hendel T, Gerber B, Sokolowski MB.Learn. Mem. 2007 May;14(5):342-9
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Maintaining a behaviour polymorphism by frequency-dependent selection on a single gene.Fitzpatrick MJ, Feder E, Rowe L, Sokolowski MB.Nature 2007 May;447(7141):210-2
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2006

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Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase.Williams KD, Busto M, Suster ML, So AK, Ben-Shahar Y, Leevers SJ, Sokolowski MB.Proc. Natl. Acad. Sci. U.S.A. 2006 Oct;103(43):15911-5
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2005

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Candidate genes for behavioural ecology.Fitzpatrick MJ, Ben-Shahar Y, Smid HM, Vet LE, Robinson GE, Sokolowski MB.Trends Ecol. Evol. (Amst.) 2005 Feb;20(2):96-104
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The neurogenetics and evolution of food-related behaviour.Douglas SJ, Dawson-Scully K, Sokolowski MB.Trends Neurosci. 2005 Dec;28(12):644-52
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Drosophila soluble guanylyl cyclase mutants exhibit increased foraging locomotion: behavioral and genomic investigations.Riedl CA, Neal SJ, Robichon A, Westwood JT, Sokolowski MB.Behav. Genet. 2005 May;35(3):231-44
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The carrot, not the stick: appetitive rather than aversive gustatory stimuli support associative olfactory learning in individually assayed Drosophila larvae.Hendel T, Michels B, Neuser K, Schipanski A, Kaun K, Sokolowski MB, Marohn F, Michel R, Heisenberg M, Gerber B.J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 2005 Mar;191(3):265-79
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2004

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In Search of Food: Exploring the Evolutionary Link Between cGMP-Dependent Protein Kinase (PKG) and Behaviour.Fitzpatrick MJ, Sokolowski MB.Integr. Comp. Biol. 2004 Feb;44(1):28-36
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Behavioral genetics: guanylyl cyclase prompts worms to party.Riedl CA, Sokolowski MB.Curr. Biol. 2004 Aug;14(16):R657-8
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Refining GAL4-driven transgene expression in Drosophila with a GAL80 enhancer-trap.Suster ML, Seugnet L, Bate M, Sokolowski MB.Genesis 2004 Aug;39(4):240-5
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Activity of cGMP-dependent protein kinase (PKG) affects sucrose responsiveness and habituation in Drosophila melanogaster.Scheiner R, Sokolowski MB, Erber J.Learn. Mem. 2004 May-Jun;11(3):303-11
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2003

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NPY and the regulation of behavioral development.Sokolowski MB.Neuron 2003 Jul;39(1):6-8
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2002

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A drosophila model for attention deficit hyperactivity disorder (ADHD): No evidence of association with PRKG1 gene.De Luca V, Muglia P, Jain U, Basile VS, Sokolowski MB, Kennedy JL.Neuromolecular Med. 2002;2(3):281-7
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Neurobiology: social eating for stress.Sokolowski MB.Nature 2002 Oct;419(6910):893-4
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