Melanie Woodin

faculty_img Academic Title: Associate Professor

Campus: St. George

CSB Appointment: Full

Primary Undergraduate Department:
Cell & Systems Biology

Graduate Programs:
Cell & Systems Biology

Titles and Honors:Academic or Administrative Appointments:
Director, Human Biology ProgramEducation:
Ph.D. University of Calgary 2001
M.Sc. University of Toronto 1997
B.Sc. University of Toronto 1995

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
Canada

 

Contact Information
Office phone: 416-978-8646
Office: RW 303B
Lab: RW302/303/323/318
Lab phone: 416-978-1406
Email: m.woodin@utoronto.ca
URL:

 

Research Areas
Cell Biology
Neurobiology

 

Research
The Woodin Lab is focused on understanding the functioning of inhibitory synapses, both at the cellular level and within neuronal circuits. We employ a multi-disciplinary approach combining electrophysiology, biochemistry, fluorescence imaging, computation biology and bioinformatics to understand how synapses are built, the mechanisms that underlie their plasticity, and their role in neuronal circuits. Using principles we learn from the study of the healthy brain we unravel mechanisms that lead to neurological disorders and dieseases, including autism spectrum disorder, Huntington’s disease and ALS.

 

Publications

 

 

2017

Top

A kainate receptor subunit promotes the recycling of the neuron-specific K+-Cl−co-transporter KCC2 in hippocampal neurons.Pressey, Jessica C., Vivek Mahadevan, C. Sahara Khademullah, Zahra Dargaei, Jonah Chevrier, Wenqing Ye, Michelle Huang, et al. 2017. Journal of Biological Chemistry.

doi

Neuronal chloride and excitability — the big impact of small changes.Raimondo, Joseph V, Blake A Richards, and Melanie A Woodin. 2017. Current Opinion in Neurobiology.

doi

 

2016

Top

Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus. Aqrabawi, Afif J., Caleb J. Browne, Zahra Dargaei, Danielle Garand, C. Sahara Khademullah, Melanie A. Woodin, and Jun Chul Kim. 2016. Nature Communications.

doi

Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.Quesnel-Vallières, Mathieu, Zahra Dargaei, Manuel Irimia, Thomas Gonatopoulos-Pournatzis, Joanna Y. Ip, Mingkun Wu, Timothy Sterne-Weiler, et al. 2016. Molecular Cell.

doi

Regulation of neuronal chloride homeostasis by neuromodulators. Mahadevan, Vivek, and Melanie A Woodin. The Journal of physiology, no. 10 (March 31) 2016. doi:10.1113/JP271593.

pubmed

 

2015

Top

Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures. Mahadevan, Vivek, Zahra Dargaei, Evgueni A Ivakine, Anna-Maria Hartmann, David Ng, Jonah Chevrier, Jake Ormond, Hans Gerd Nothwang, Roderick R McInnes, and Melanie A Woodin. Frontiers in cellular neuroscience (September 23). doi:10.3389/fncel.2015.00368. pubmed
Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.Meyer M, Reimand J, Lan X, Head R, Zhu X, Kushida M, Bayani J, Pressey JC, Lionel AC, Clarke ID, Cusimano M, Squire JA, Scherer SW, Bernstein M, Woodin MA, Bader GD, Dirks PB.Proc. Natl. Acad. Sci. U.S.A. 2015 Jan;112(3):851-6 pubmed
 

2014

Top

Parvalbumin and GAD65 interneuron inhibition in the ventral hippocampus induces distinct behavioral deficits relevant to schizophrenia.Nguyen R, Morrissey MD, Mahadevan V, Cajanding JD, Woodin MA, Yeomans JS, Takehara-Nishiuchi K, Kim JC.J. Neurosci. 2014 Nov;34(45):14948-60
pubmed
Neurons Are Recruited to a Memory Trace Based on Relative Neuronal Excitability Immediately before Training.Yiu AP, Mercaldo V, Yan C, Richards B, Rashid AJ, Hsiang HL, Pressey J, Mahadevan V, Tran MM, Kushner SA, Woodin MA, Frankland PW, Josselyn SA.Neuron 2014 Aug;83(3):722-35
pubmed
Kainate receptors coexist in a functional complex with KCC2 and regulate chloride homeostasis in hippocampal neurons.Mahadevan V, Pressey JC, Acton BA, Uvarov P, Huang MY, Chevrier J, Puchalski A, Li CM, Ivakine EA, Airaksinen MS, Delpire E, McInnes RR, Woodin MA.Cell Rep 2014 Jun;7(6):1762-70
pubmed
Patterns across multiple memories are identified over time.Richards BA, Xia F, Santoro A, Husse J, Woodin MA, Josselyn SA, Frankland PW.Nat. Neurosci. 2014 Jul;17(7):981-6
pubmed
 

2013

Top

Muscarinic acetylcholine receptor activation prevents disinhibition-mediated LTP in the hippocampus.Takkala P, Woodin MA.Front Cell Neurosci 2013;7:16
pubmed
Neto2 is a KCC2 interacting protein required for neuronal Cl- regulation in hippocampal neurons.Ivakine EA, Acton BA, Mahadevan V, Ormond J, Tang M, Pressey JC, Huang MY, Ng D, Delpire E, Salter MW, Woodin MA, McInnes RR.Proc. Natl. Acad. Sci. U.S.A. 2013 Feb;110(9):3561-6
pubmed
 

2012

Top

Increasing CRTC1 function in the dentate gyrus during memory formation or reactivation increases memory strength without compromising memory quality.Sekeres MJ, Mercaldo V, Richards B, Sargin D, Mahadevan V, Woodin MA, Frankland PW, Josselyn SA.J. Neurosci. 2012 Dec;32(49):17857-68
pubmed
Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!.Ben-Ari Y, Woodin MA, Sernagor E, Cancedda L, Vinay L, Rivera C, Legendre P, Luhmann HJ, Bordey A, Wenner P, Fukuda A, van den Pol AN, Gaiarsa JL, Cherubini E.Front Cell Neurosci 2012;6:35
pubmed
Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain.Acton BA, Mahadevan V, Mercado A, Uvarov P, Ding Y, Pressey J, Airaksinen MS, Mount DB, Woodin MA.J. Neurosci. 2012 Jun;32(25):8746-51
pubmed
 

2011

Top

Disinhibition-Mediated LTP in the Hippocampus is Synapse Specific.Ormond J, Woodin MA.Front Cell Neurosci 2011;5:17
pubmed
Endogenous GABA(A) and GABA(B) receptor-mediated electrical suppression is critical to neuronal anoxia tolerance.Pamenter ME, Hogg DW, Ormond J, Shin DS, Woodin MA, Buck LT.Proc. Natl. Acad. Sci. U.S.A. 2011 Jul;108(27):11274-9
pubmed
 

2010

Top

GABAergic synaptic transmission regulates calcium influx during spike-timing dependent plasticity.Balena T, Acton BA, Woodin MA.Front Synaptic Neurosci 2010;2:16
pubmed
Spike-timing dependent plasticity in inhibitory circuits.Lamsa KP, Kullmann DM, Woodin MA.Front Synaptic Neurosci 2010;2:8
pubmed
 

2009

Top

Disinhibition mediates a form of hippocampal long-term potentiation in area CA1.Ormond J, Woodin MA.PLoS ONE 2009;4(9):e7224
pubmed
 

2008

Top

Coincident pre- and postsynaptic activity downregulates NKCC1 to hyperpolarize E(Cl) during development.Balena T, Woodin MA.Eur. J. Neurosci. 2008 May;27(9):2402-12
pubmed
Extracellular potassium regulates the chloride reversal potential in cultured hippocampal neurons.Balena T, Acton BA, Koval D, Woodin MA.Brain Res. 2008 Apr;1205:12-20
pubmed
 

2007

Top

Role of activity-dependent regulation of neuronal chloride homeostasis in development.Fiumelli H, Woodin MA.Curr. Opin. Neurobiol. 2007 Feb;17(1):81-6
pubmed
 

2006

Top

Recent advances in basic neurosciences and brain disease: from synapses to behavior.Bi GQ, Bolshakov V, Bu G, Cahill CM, Chen ZF, Collingridge GL, Cooper RL, Coorssen JR, El-Husseini A, Galhardo V, Gan WB, Gu J, Inoue K, Isaac J, Iwata K, Jia Z, Kaang BK, Kawamata M, Kida S, Klann E, Kohno T, Li M, Li XJ, MacDonald JF, Nader K, Nguyen PV, Oh U, Ren K, Roder JC, Salter MW, Song W, Sugita S, Tang SJ, Tao Y, Wang YT, Woo N, Woodin MA, Yan Z, Yoshimura M, Xu M, Xu ZC, Zhang X, Zhen M, Zhuo M.Mol Pain 2006;2:38
pubmed
Excitatory actions of GABA mediate severe-hypoxia-induced depression of neuronal activity in the pond snail (Lymnaea stagnalis).Cheung U, Moghaddasi M, Hall HL, Smith JJ, Buck LT, Woodin MA.J. Exp. Biol. 2006 Nov;209(Pt 22):4429-35
pubmed
 

2003

Top

Coincident pre- and postsynaptic activity modifies GABAergic synapses by postsynaptic changes in Cl- transporter activity.Woodin MA, Ganguly K, Poo MM.Neuron 2003 Aug;39(5):807-20
pubmed
 

2002

Top

Trophic factor-induced excitatory synaptogenesis involves postsynaptic modulation of nicotinic acetylcholine receptors.Woodin MA, Munno DW, Syed NI.J. Neurosci. 2002 Jan;22(2):505-14
pubmed