Patrick McGowan

faculty_img Academic Title: Associate Professor

Campus: UTSC

CSB Appointment: Full

Primary Undergraduate Department:
Biological Sciences, UTSC

Graduate Programs:
Cell & Systems Biology
Ecology & Evolutionary Biology

Titles and Honors:


Academic or Administrative Appointments:


Education:
Ph.D. Duke University
B.Sc. Concordia University

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4
Canada

 

Contact Information
Office phone: 416-208-5153
Office: SW 564
Lab: SW 538
Lab phone:
Email: pmcgowan@utsc.utoronto.ca
URL: http://www.utsc.utoronto.ca/~pmcgowan/

 

Research Areas
Animal Biology
Bioinformatics & Computational Biology
Functional Genomics
Genetics
Neurobiology
Physiology
Psychology & Behavior
Systems Biology

 

Research

We use techniques in molecular biology, behavioural neuroscience, and functional genomics to study phenotype. A major focus of the lab is the role of epigenetic mechanisms that confer inter-individual variation in glucocorticoid signaling pathways. Social factors, infections, toxins and disease can all influence gluccorticoid signaling. As such, glucocorticoid signaling pathways act as sensors for environmental signals that affect a range of physiological functions from the response to stress to inflammation. Another major focus in the lab is the role of early life environmental adversity in altering brain and behaviour later in life via epigenetic mechanisms. We study a variety of organisms, from animals in the lab to wild populations and humans.

 

Publications

2014

Top
DNA Methylation Modifications Associated with Chronic Fatigue Syndrome.de Vega WC, Vernon SD, McGowan PO.PLoS ONE 2014;9(8):e104757
pubmed
Cocaine exposure prior to pregnancy alters the psychomotor response to cocaine and transcriptional regulation of the dopamine D1 receptor in adult male offspring.Sasaki A, Constantinof A, Pan P, Kupferschmidt DA, McGowan PO, Erb S.Behav. Brain Res. 2014 May;265:163-70
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2013

Top
Epigenomic Mechanisms of Early Adversity and HPA Dysfunction: Considerations for PTSD Research.McGowan PO.Front Psychiatry 2013;4:110
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Biological embedding in mental health: an epigenomic perspective.Sasaki A, de Vega WC, McGowan PO.Biochem. Cell Biol. 2013 Feb;91(1):14-21
pubmed

2012

Top
Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus.Suderman M, McGowan PO, Sasaki A, Huang TC, Hallett MT, Meaney MJ, Turecki G, Szyf M.Proc. Natl. Acad. Sci. U.S.A. 2012 Oct;109 Suppl 2:17266-72
pubmed
Epigenetic clues to the biological embedding of early life adversity.McGowan PO.Biol. Psychiatry 2012 Jul;72(1):4-5
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2011

Top
Broad epigenetic signature of maternal care in the brain of adult rats.McGowan PO, Suderman M, Sasaki A, Huang TC, Hallett M, Meaney MJ, Szyf M.PLoS ONE 2011;6(2):e14739
pubmed
Impaired social recognition memory in recombination activating gene 1-deficient mice.McGowan PO, Hope TA, Meck WH, Kelsoe G, Williams CL.Brain Res. 2011 Apr;1383:187-95
pubmed

2010

Top
The Neurological Ecology of Fear: Insights Neuroscientists and Ecologists Have to Offer one Another.Clinchy M, Schulkin J, Zanette LY, Sheriff MJ, McGowan PO, Boonstra R.Front Behav Neurosci 2010;4:21
pubmed
Environmental epigenomics: understanding the effects of parental care on the epigenome.McGowan PO, Szyf M.Essays Biochem. 2010 Sep;48(1):275-87
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The epigenetics of social adversity in early life: implications for mental health outcomes.McGowan PO, Szyf M.Neurobiol. Dis. 2010 Jul;39(1):66-72
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2009

Top
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse.McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonté B, Szyf M, Turecki G, Meaney MJ.Nat. Neurosci. 2009 Mar;12(3):342-8
pubmed

2008

Top
Epigenetics in mood disorders.McGowan PO, Kato T.Environ Health Prev Med 2008 Jan;13(1):16-24
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Diet and the epigenetic (re)programming of phenotypic differences in behavior.McGowan PO, Meaney MJ, Szyf M.Brain Res. 2008 Oct;1237:12-24
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The effects of pH on DNA methylation state: In vitro and post-mortem brain studies.Ernst C, McGowan PO, Deleva V, Meaney MJ, Szyf M, Turecki G.J. Neurosci. Methods 2008 Sep;174(1):123-5
pubmed
Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain.McGowan PO, Sasaki A, Huang TC, Unterberger A, Suderman M, Ernst C, Meaney MJ, Turecki G, Szyf M.PLoS ONE 2008;3(5):e2085
pubmed