Rodrigo Fernandez-Gonzalez

rodrigo fernandez-gonzalez Academic Title: Assistant Professor

Campus: St. George

CSB Appointment: Cross Appointment

Primary Undergraduate Department:
Institute of Biomaterials and Biomedical Engineering (IBBME)

Graduate Programs:
Cell & Systems Biology
Ecology & Evolutionary Biology

Titles and Honors:
Academic or Administrative Appointments:
Education:
Ph.D. University of California, Berkeley and San Francisco 2006
B.Sc. Universidad Autonoma, Madrid, Spain 2000

 

Mailing Address
Institute of Biomaterials & Biomedical Engineering
University of Toronto
164 College St..
Toronto, ON M5S 3G9
Canada

 

Contact Information
Office phone: 416-978-7368
Office: RS 405
Lab:
Lab phone:
Email: rodrigo.fernandez.gonzalez@utoronto.ca
URL: http://individual.utoronto.ca/quantmorph

 

Research Areas
Cell Biology
Developmental Biology
Quantitative Biology

 

Research

During morphogenesis, groups of cells coordinate their behaviors to generate tissue form and function. Cell coordination involves diverse cellular processes such as motility, adhesion, and the generation and transmission of mechanical forces. We use a combination of bioengineering, molecular and cell biological tools in the fruit fly embryo to determine the mechanisms that integrate the behaviors of multiple cells to generate specific changes in tissue organization. Wound repair is a conserved morphogenetic process that involves changes in cell shape, molecular localization and the distribution of mechanical forces to close a gap in a tissue. Because wound closure in embryos occurs in the absence of inflammation or scarring, understanding its molecular basis will be of high clinical relevance for surgical recovery and regenerative medicine. We investigate the molecular and cellular mechanisms of wound healing using a three-pronged approach. First, we use computational and live imaging approaches to determine the dynamic cell shape and molecular changes involved in wound closure in the Drosophila embryo. Second, we screen for molecules that mediate the assembly of force-generating structures during wound healing. Finally, we use biophysical methods to investigate how wound repair is influenced by the mechanical properties of the wounded tissue, and how these properties are regulated during the healing process.

 

Publications