Sergio Peisajovich

faculty_img Academic Title: Assistant Professor

Campus: St. George

CSB Appointment: Full

Primary Undergraduate Department:
Cell & Systems Biology

Graduate Programs:
Cell & Systems Biology
Neuroscience
Psychology

Titles and Honors:

Academic or Administrative Appointments:

Education:
Ph.D. Weizmann Institute of Science 2003
B.Sc. University of Buenos Aires 1998

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
Canada

 

Contact Information
Office phone: 416-978-2143
Office:
Lab: RW 331/332
Lab phone: 416-978-2308
Email: sergio.peisajovich@utoronto.ca
URL: http://labs.csb.utoronto.ca/peisajovich/

 

Research Areas
Biotechnology
Cell Biology
Evolutionary Biology
Synthetic Biology
Systems Biology

 

Research

Our research focuses on the following specific areas: 1. Evolution of Signaling Networks Signaling networks’ functions are altered by genetic change. Some changes may lead to adaptive evolution. We are investigating how mutations, such as gene duplication, recombination, or amino acid substitutions, affect the function of signaling networks. 2. Signaling Network Malfunction and Disease While some mutations are beneficial, many others are detrimental, sometimes leading to disease. For instance, cancer often arises from mutations in signaling pathways that control cell growth. We are developing high-throughput model systems to investigate the relationship between signaling network malfunction and disease. 3. Synthetic Biology of Signaling Networks The ability to precisely control the function of signaling networks will open the door to endless biotechnological applications, including cell-based therapies, biosensors or microbiological platforms for the production of biochemicals and biofuels. We are developing synthetic biology methods based on the unique bioengineering abilities of evolution.

 

Publications

2014

Top
Current approaches in evolution: From molecules to cells and organisms.Thattai M, Peisajovich SG.J. Exp. Zool. B Mol. Dev. Evol. 2014 Jul;
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The role of domain shuffling in the evolution of signaling networks.Di Roberto RB, Peisajovich SG.J. Exp. Zool. B Mol. Dev. Evol. 2014 Feb;322(2):65-72
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2012

Top
Evolutionary synthetic biology.Peisajovich SG.ACS Synth Biol 2012 Jun;1(6):199-210
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Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells.Wei P, Wong WW, Park JS, Corcoran EE, Peisajovich SG, Onuffer JJ, Weiss A, Lim WA.Nature 2012 Aug;488(7411):384-8
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2010

Top
Rapid diversification of cell signaling phenotypes by modular domain recombination.Peisajovich SG, Garbarino JE, Wei P, Lim WA.Science 2010 Apr;328(5976):368-72
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Rewiring cells: synthetic biology as a tool to interrogate the organizational principles of living systems.Bashor CJ, Horwitz AA, Peisajovich SG, Lim WA.Annu Rev Biophys 2010;39:515-37
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2007

Top
Protein engineers turned evolutionists.Peisajovich SG, Tawfik DS.Nat. Methods 2007 Dec;4(12):991-4
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2006

Top
Amplification of complex gene libraries by emulsion PCR.Williams R, Peisajovich SG, Miller OJ, Magdassi S, Tawfik DS, Griffiths AD.Nat. Methods 2006 Jul;3(7):545-50
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Evolution of new protein topologies through multistep gene rearrangements.Peisajovich SG, Rockah L, Tawfik DS.Nat. Genet. 2006 Feb;38(2):168-74
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2003

Top
Liposomes in identification and characterization of viral fusogenic peptides.Peisajovich SG, Shai Y.Meth. Enzymol. 2003;372:361-73
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Viral fusion proteins: multiple regions contribute to membrane fusion.Peisajovich SG, Shai Y.Biochim. Biophys. Acta 2003 Jul;1614(1):122-9
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C-terminal octylation rescues an inactive T20 mutant: implications for the mechanism of HIV/SIMIAN immunodeficiency virus-induced membrane fusion.Peisajovich SG, Gallo SA, Blumenthal R, Shai Y.J. Biol. Chem. 2003 Jun;278(23):21012-7
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On the interaction between gp41 and membranes: the immunodominant loop stabilizes gp41 helical hairpin conformation.Peisajovich SG, Blank L, Epand RF, Epand RM, Shai Y.J. Mol. Biol. 2003 Mar;326(5):1489-501
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2002

Top
Sendai virus N-terminal fusion peptide consists of two similar repeats, both of which contribute to membrane fusion.Peisajovich SG, Epand RF, Epand RM, Shai Y.Eur. J. Biochem. 2002 Sep;269(17):4342-50
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New insights into the mechanism of virus-induced membrane fusion.Peisajovich SG, Shai Y.Trends Biochem. Sci. 2002 Apr;27(4):183-90
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High similarity between reverse-oriented sequences from HIV and foamy virus envelope glycoproteins.Peisajovich SG, Shai Y.AIDS Res. Hum. Retroviruses 2002 Mar;18(4):309-12
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