Vincent Tropepe

faculty_img Academic Title: Professor & Chair

Campus: St. George

CSB Appointment: Full

Primary Undergraduate Department: Cell & Systems Biology

Graduate Programs: Cell & Systems Biology

Academic or Administrative Appointments Department Chair

Education:
Ph.D. University of Toronto 2000
B.Sc. McMaster University 1994

Mailing Address
Department of Cell & Systems Biology
University of Toronto
25 Harbord St. Toronto, ON
M5S 3G5 Canada

 

Contact Information
Office phone: 416-978-3500/946-0338
Office: RW 434A/618A
Lab: RW 607 / 618
Lab phone: 416-946-0593/7218
Email: v.tropepe@utoronto.ca
URL: http://www.utoronto.ca/tropepe-lab/

 

Research Areas
Cell Biology Developmental Biology Functional Genomics Genetics Molecular Biology Neurobiology

 

Research

The production of nerve cells (neurogenesis) is a life-long process with regional specialization that is critical for the formation of distinct functional domains in the vertebrate nervous system. Moreover, neurogenesis in the mature nervous system may contribute to the structural changes that underlie neural plasticity, which is crucial for sensory processing and behaviour. My lab investigates how neurogenesis contributes to the generation and maintenance of regional nerve cell diversity throughout life. We utilize various molecular genetic techniques in order to identify and characterize the molecular mechanisms that govern vertebrate neurogenesis.

 

Publications

2014

Top
Changes in the social environment induce neurogenic plasticity predominantly in niches residing in sensory structures of the zebrafish brain independently of cortisol levels.Lindsey BW, Tropepe V.Dev Neurobiol 2014 Apr;
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Casting a wider fish net on animal models in neuropsychiatric research.Hall ZJ, De Serrano AR, Rodd FH, Tropepe V.Prog. Neuropsychopharmacol. Biol. Psychiatry 2014 Apr;
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2013

Top
Cockayne syndrome b maintains neural precursor function.Sacco R, Tamblyn L, Rajakulendran N, Bralha FN, Tropepe V, Laposa RR.DNA Repair (Amst.) 2013 Feb;12(2):110-20
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2012

Top
Toll-like signaling and the cytokine IL-6 regulate histone deacetylase dependent neuronal survival.Forgione N, Tropepe V.PLoS ONE 2012;7(7):e41033
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Zfhx1b induces a definitive neural stem cell fate in mouse embryonic stem cells.Dang LT, Wong L, Tropepe V.Stem Cells Dev. 2012 Oct;21(15):2838-51
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The ontogeny of somatic stem cells.Tropepe V, Turksen K.Stem Cell Rev 2012 Jun;8(2):548-50
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The cellular composition of neurogenic periventricular zones in the adult zebrafish forebrain.Lindsey BW, Darabie A, Tropepe V.J. Comp. Neurol. 2012 Jul;520(10):2275-316
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2011

Top
Histone deacetylase inhibition promotes Caspase-independent cell death of ventral midbrain neurons.Forgione N, Tropepe V.Mol. Cell. Neurosci. 2011 Oct;48(2):117-28
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The role of dopaminergic signalling during larval zebrafish brain development: a tool for investigating the developmental basis of neuropsychiatric disorders.Souza BR, Tropepe V.Rev Neurosci 2011;22(1):107-19
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Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.Souza BR, Romano-Silva MA, Tropepe V.J. Neurosci. 2011 Apr;31(14):5512-25
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The PI3K/Akt/mTOR pathway mediates retinal progenitor cell survival under hypoxic and superoxide stress.Sanghera KP, Mathalone N, Baigi R, Panov E, Wang D, Zhao X, Hsu H, Wang H, Tropepe V, Ward M, Boyd SR.Mol. Cell. Neurosci. 2011 Jun;47(2):145-53
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2010

Top
Waste management and adult neurogenesis.Mattocks M, Tropepe V.Cell Stem Cell 2010 Oct;7(4):421-2
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Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development.Wong L, Weadick CJ, Kuo C, Chang BS, Tropepe V.BMC Dev. Biol. 2010;10:100
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FGF dependent regulation of Zfhx1b gene expression promotes the formation of definitive neural stem cells in the mouse anterior neurectoderm.Dang LT, Tropepe V.Neural Dev 2010;5:13
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2009

Top
Neurogenic potential of isolated precursor cells from early post-gastrula somitic tissue.Tropepe V, Alton K, Sachewsky N, Cheng V, Kuo C, Morshead CM.Stem Cells Dev. 2009 Dec;18(10):1533-42
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2007

Top
Kinship and descent: redefining the stem cell compartment in the adult hippocampus.Tropepe V.Cell Stem Cell 2007 Nov;1(5):481-3
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Kinship and Descent: Redefining the Stem Cell Compartment in the Adult Hippocampus.Tropepe V.Cell Stem Cell 2007 Nov;1(5):481-483
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2006

Top
Neural induction and neural stem cell development.Dang L, Tropepe V.Regen Med 2006 Sep;1(5):635-52
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A comparative framework for understanding the biological principles of adult neurogenesis.Lindsey BW, Tropepe V.Prog. Neurobiol. 2006 Dec;80(6):281-307
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Genomic sequence and spatiotemporal expression comparison of zebrafish mbx1 and its paralog, mbx2.Chang L, Khoo B, Wong L, Tropepe V.Dev. Genes Evol. 2006 Oct;216(10):647-54
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Identification of a BMP inhibitor-responsive promoter module required for expression of the early neural gene zic1.Tropepe V, Li S, Dickinson A, Gamse JT, Sive HL.Dev. Biol. 2006 Jan;289(2):517-29
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2002

Top
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.Hitoshi S, Alexson T, Tropepe V, Donoviel D, Elia AJ, Nye JS, Conlon RA, Mak TW, Bernstein A, van der Kooy D.Genes Dev. 2002 Apr;16(7):846-58
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Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain.Hitoshi S, Tropepe V, Ekker M, van der Kooy D.Development 2002 Jan;129(1):233-44
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