Ian Brown

faculty_img Academic Title: Professor

Campus: UTSC

CSB Appointment: Full

Primary Undergraduate Department:
Biological Sciences, UTSC

Graduate Programs:
Cell & Systems Biology
Neuroscience

Titles and Honors:
Canada Research Chair in Neuroscience
Honorary Professor, University College London, UK

Academic or Administrative Appointments:


Education:
Ph.D. University of Texas 1969
B.Sc. Carleton University 1966

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4
Canada
 

 

Contact Information
Office phone: 416-287-7413 
Office: SW 540 
Lab: S 536 
Lab phone: 416-287-7411 
Email: ibrown@utsc.utoronto.ca 
URL:

 

Research Areas
Cell Biology
Molecular Biology
Neurobiology

 

Research

The frequency of neurodegenerative diseases in the human population is increasing as average life span lengthens, hence the search for effective therapies is a pressing challenge. Neurodegenerative diseases have been termed ‘protein misfolding disorders’ as aggregation-prone, misfolded proteins accumulated in neural cells triggering pathogenic cascades that result in cell death of specific population of neurons in the brain. Heat shock proteins are ‘protein repair agents’ that can detect misfolded proteins and facilitated their correct refolding. Upregulation of heat shock proteins in the nervous system is being explored in my laboratory as a potential strategy to combat neurodegenerative diseases that have been classified as protein misfolding disorders.

 

Publications

 

2017

Top

Differential Targeting of Hsp70 Heat Shock Proteins HSPA6 and HSPA1A with Components of a Protein Disaggregation/Refolding Machine in Differentiated Human Neuronal Cells following Thermal Stress. Deane CAS, Brown IR. Front Neurosci. 2017 Apr 24;11:227. doi: 10.3389/fnins.2017.00227. eCollection 2017.
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Components of a mammalian protein disaggregation/refolding machine are targeted to nuclear speckles following thermal stress in differentiated human neuronal cells. Deane CA, Brown IR. Cell Stress Chaperones. 2017 Mar;22(2):191-200. doi: 10.1007/s12192-016-0753-x. Epub 2016 Dec 13.
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Targeting of Heat Shock Protein HSPA6 (HSP70B’) to the Periphery of Nuclear Speckles is Disrupted by a Transcription Inhibitor Following Thermal Stress in Human Neuronal Cells. Becirovic L, Brown IR. Neurochem Res. 2017 Feb;42(2):406-414. doi: 10.1007/s11064-016-2084-9. Epub 2016 Oct 14.
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2016

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Dynamics of the association of heat shock protein HSPA6 (Hsp70B’) and HSPA1A (Hsp70-1) with stress-sensitive cytoplasmic and nuclear structures in differentiated human neuronal cells. Shorbagi S, Brown IR. Cell Stress Chaperones. 2016 Nov;21(6):993-1003. Epub 2016 Aug 16.
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Induction of heat shock proteins in differentiated human neuronal cells following co-application of celastrol and arimoclomol. Deane CA, Brown IR. Cell Stress Chaperones. 2016 Sep;21(5):837-48. doi: 10.1007/s12192-016-0708-2. Epub 2016 Jun 8.
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2015

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Heat shock response and homeostatic plasticity.Karunanithi S, Brown IR.Front Cell Neurosci 2015;9:68
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2014

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Localization of heat shock protein HSPA6 (HSP70B’) to sites of transcription in cultured differentiated human neuronal cells following thermal stress.Khalouei S, Chow AM, Brown IR.J. Neurochem. 2014 Dec;131(6):743-54
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Electrochemical immunosensors for effective evaluation of amyloid-beta modulators on oligomeric and fibrillar aggregation processes.Veloso AJ, Chow AM, Ganesh HV, Li N, Dhar D, Wu DC, Mikhaylichenko S, Brown IR, Kerman K.Anal. Chem. 2014 May;86(10):4901-9
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Localization of heat shock proteins in cerebral cortical cultures following induction by celastrol.Chow AM, Tang DW, Hanif A, Brown IR.Cell Stress Chaperones 2014 Apr;
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Stress-induced localization of HSPA6 (HSP70B’) and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cells.Khalouei S, Chow AM, Brown IR.Cell Stress Chaperones 2014 May;19(3):321-7
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2013

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Quantum dot based fluorometric detection of cancer TF-antigen.Li N, Chow AM, Ganesh HV, Brown IR, Kerman K.Anal. Chem. 2013 Oct;85(20):9699-704
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Biological activity of sym-triazines with acetylcholine-like substitutions as multitarget modulators of Alzheimer’s disease.Veloso AJ, Chow AM, Dhar D, Tang DW, Ganesh HV, Mikhaylichenko S, Brown IR, Kerman K.ACS Chem Neurosci 2013 Jun;4(6):924-9
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sym-Triazines for directed multitarget modulation of cholinesterases and amyloid-β in Alzheimer’s disease.Veloso AJ, Dhar D, Chow AM, Zhang B, Tang DW, Ganesh HV, Mikhaylichenko S, Brown IR, Kerman K.ACS Chem Neurosci 2013 Feb;4(2):339-49
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Induction of heat shock proteins in cerebral cortical cultures by celastrol.Chow AM, Tang DW, Hanif A, Brown IR.Cell Stress Chaperones 2013 Mar;18(2):155-60
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2012

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CSSI workshop in Brazil highlights “Stress Responses in the Nervous System” in relation to neurodegenerative diseases and neuroprotection.Brown IR.Cell Stress Chaperones 2012 Nov;17(6):657-60
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Oxidative stress effect of dopamine on α-synuclein: electroanalysis of solvent interactions.Chan T, Chow AM, Cheng XR, Tang DW, Brown IR, Kerman K.ACS Chem Neurosci 2012 Jul;3(7):569-74
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Hsp60 protein pattern in coral is altered by environmental changes in light and temperature.Chow AM, Beraud E, Tang DW, Ferrier-Pagès C, Brown IR.Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 2012 Mar;161(3):349-53
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2011

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Induction of heat shock proteins in the adult rat cerebral cortex following pilocarpine-induced status epilepticus.Lively S, Brown IR.Brain Res. 2011 Jan;1368:271-80
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2010

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Heteromeric complexes of heat shock protein 70 (HSP70) family members, including Hsp70B’, in differentiated human neuronal cells.Chow AM, Mok P, Xiao D, Khalouei S, Brown IR.Cell Stress Chaperones 2010 Sep;15(5):545-53
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The extracellular matrix protein SC1/Hevin localizes to multivesicular bodies in Bergmann glial fibers in the adult rat cerebellum.Lively S, Brown IR.Neurochem. Res. 2010 Feb;35(2):315-22
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2009

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Increased light intensity induces heat shock protein Hsp60 in coral species.Chow AM, Ferrier-Pagès C, Khalouei S, Reynaud S, Brown IR.Cell Stress Chaperones 2009 Sep;14(5):469-76
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2008

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Extracellular matrix protein SC1/hevin in the hippocampus following pilocarpine-induced status epilepticus.Lively S, Brown IR.J. Neurochem. 2008 Dec;107(5):1335-46
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The extracellular matrix protein SC1/hevin localizes to excitatory synapses following status epilepticus in the rat lithium-pilocarpine seizure model.Lively S, Brown IR.J. Neurosci. Res. 2008 Oct;86(13):2895-905
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Localization of the extracellular matrix protein SC1 coincides with synaptogenesis during rat postnatal development.Lively S, Brown IR.Neurochem. Res. 2008 Sep;33(9):1692-700
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2007

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Induction of heat shock proteins in differentiated human and rodent neurons by celastrol.Chow AM, Brown IR.Cell Stress Chaperones 2007;12(3):237-44
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Heat shock proteins and protection of the nervous system.Brown IR.Ann. N. Y. Acad. Sci. 2007 Oct;1113:147-58
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Analysis of the extracellular matrix protein SC1 during reactive gliosis in the rat lithium-pilocarpine seizure model.Lively S, Brown IR.Brain Res. 2007 Aug;1163:1-9
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Developmental changes in the association of NMDA receptors with lipid rafts.Besshoh S, Chen S, Brown IR, Gurd JW.J. Neurosci. Res. 2007 Jul;85(9):1876-83
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Neuronal expression of constitutive heat shock proteins: implications for neurodegenerative diseases.Chen S, Brown IR.Cell Stress Chaperones 2007;12(1):51-8
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Translocation of constitutively expressed heat shock protein Hsc70 to synapse-enriched areas of the cerebral cortex after hyperthermic stress.Chen S, Brown IR.J. Neurosci. Res. 2007 Feb;85(2):402-9
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Localization of the extracellular matrix protein SC1 to synapses in the adult rat brain.Lively S, Ringuette MJ, Brown IR.Neurochem. Res. 2007 Jan;32(1):65-71
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2006

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Cell death and expression of heat-shock protein Hsc70 in the hyperthermic rat brain.Belay HT, Brown IR.J. Neurochem. 2006 Apr;97 Suppl 1:116-9
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2005

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Association of heat shock proteins and neuronal membrane components with lipid rafts from the rat brain.Chen S, Bawa D, Besshoh S, Gurd JW, Brown IR.J. Neurosci. Res. 2005 Aug;81(4):522-9
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2003

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Spatial analysis of cell death and Hsp70 induction in brain, thymus, and bone marrow of the hyperthermic rat.Belay HT, Brown IR.Cell Stress Chaperones 2003;8(4):395-404
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Induction of Hsp27 and Hsp32 stress proteins and vimentin in glial cells of the rat hippocampus following hyperthermia.Bechtold DA, Brown IR.Neurochem. Res. 2003 Aug;28(8):1163-73
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2002

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Effect of hyperthermia on the transport of mRNA encoding the extracellular matrix glycoprotein SC1 into Bergmann glial cell processes.Mothe AJ, Brown IR.Brain Res. 2002 Mar;931(2):146-58
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The effect of hyperthermia on the induction of cell death in brain, testis, and thymus of the adult and developing rat.Khan VR, Brown IR.Cell Stress Chaperones 2002 Jan;7(1):73-90
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Enhancement of presynaptic performance in transgenic Drosophila overexpressing heat shock protein Hsp70.Karunanithi S, Barclay JW, Brown IR, Robertson RM, Atwood HL.Synapse 2002 Apr;44(1):8-14
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