|Department of Chemical and Physical Sciences
University of Toronto
3359 Mississauga Road
Mississauga, ON L5L 1C6
|Office phone: 905-569-4598
Office: DV 4053
Lab: DV 5032
Lab phone: 905-828-5436
My research focuses on studying the conformational dynamics of DNA, which, while being intimately involved in genetic function, has operational effects that are not well understood at present. Errors in genetic expression, besides arising from mistakes in the code itself, could also manifest by macromolecules that over-twist or over-stretch the DNA, problems in packing within the nucleus, long-range interference between genes, and so on. Studying the dynamics of DNA, while challenging, has the potential to define a new paradigm for our understanding of cellular function, which could have a range of implications for our understanding of health and disease.
1: Singh K, Milstein JN, Navarre WW. Xenogeneic Silencing and Its Impact on
Bacterial Genomes. Annu Rev Microbiol. 70, 199-213 (2016). [Epub ahead of print] PubMed
2: Y. Wang, P. Penkul and J. N. Milstein, Quantitative localization microscopy reveals
a novel organization of a high-copy number plasmid, Biophys. J. 111, 467-479 (2016).
3: Mazouchi A, Milstein JN. Fast Optimized Cluster Algorithm for Localizations
(FOCAL): a spatial cluster analysis for super-resolved microscopy.
Bioinformatics. 2016 Mar 1;32(5):747-54. doi: 10.1093/bioinformatics/btv630. Epub
2015 Nov 4. PubMed PMID: 26543172.
4: Wang H, Yehoshua S, Ali SS, Navarre WW, Milstein JN. A biomechanical mechanism
for initiating DNA packaging. Nucleic Acids Res. 2014 Oct 29;42(19):11921-7. doi:
10.1093/nar/gku896. Epub 2014 Oct 1. PubMed PMID: 25274732; PubMed Central PMCID:
For an up to date list of publications please visit: http://www.utm.utoronto.ca/milsteinlab/publications/.