Memory-Associated Dynamic Regulation of the “Stable” Core of the Chromatin Particle

Zovkic IB, Sweatt JD

Neuron 2015 Jul;87(1):1-4

PMID: 26139363


Chromatin is a critical regulator of neural plasticity, but basic principles of chromatin function in neurons are unclear. In this issue of Neuron, Maze et al. (2015) establish histone H3.3 turnover as a novel mechanism contributing to CNS gene regulation, synaptic plasticity, and cognition.