Michael Reber

faculty_img Academic Title: Associate Professor

Campus: St. George

CSB Appointment: Cross Appointment

Primary Undergraduate Department: Department of Opthamology and Vision Science

Graduate Programs:
Laboratory Medicine and Pathobiology
Cell and Systems Biology

Academic or Administrative Appointments

Education:
Ph.D. Genetics, Diderot University, Paris (FR) 2000,
MSc Life Sciences, Diderot University, Paris (FR) 1996

Mailing Address
Krembil Research Institute – KDT
60 Leonard Avenue
Toronto, ON
M5G 0S8

 

Contact Information
Office phone: 416-634-7937
Office: 8KD419
Lab phone: 416-634-8177
Lab: 8KD417
Email: michael.reber@uhnresearch.ca
URL: http://www.reberlab.com/

 

Research Areas

Neurobiology
Systems Biology
Molecular Biology
Bioinformatics & Computational Biology
Cell Biology
Psychology & Behavior

 

Research


Brain function relies on the efficient processing of sensory information which requires formation and interaction of sensory maps in different areas. Vision is the prevailing sense in several species including humans. Visual information is carried by the optic nerve to different brain structures, among them the superior colliculus (SC) involved in the control of visual attention.
1) What are the mechanisms governing visual network formation in the SC?
2) How do neurodegenerative diseases impact the integrity of the network?
3) What are the behavioral consequences of a defective wiring?
These are the fundamental questions we address using state-of-the-art experimental and theoretical approaches.
1) We study the role and mechanism of action of different families of guidance cues involved in the control of visual maps formation in rodent models. We generate computational models to simulate these mapping processes.
2) We ask whether and how the visual system compensates for a loss of connectivity in animal models of neurodegenerative diseases. We analyze visual maps integrity and seek to identify the molecular mechanisms of compensation/adaptation.
3) Defective visual maps in the SC lead to attentional deficits in animal models, consistent with the SC’s function. We ask whether manipulating/training visual attention using high-tech devices can affect/improve behavioral responses.
We believe this integrated view of visual system development and function will provide answers as to how vision develops and works in normal and pathological contexts and what can be done to restore/preserve vision in neurodegenerative diseases.

 

Publications

 

 

2018

Top

Visual Maps Development: Reconsidering the Role of Retinal Efnas and Basic Principle of Map Alignment. Savier E, Reber M. Front Cell Neurosci. 2018 Mar 21;12:77. doi: 10.3389/fncel.2018.00077. eCollection 2018.
pubmed
 

2017

Top

A molecular mechanism for the topographic alignment of convergent neural maps. Savier E, Eglen SJ, Bathélémy A, Perraut M, Pfrieger FW, Lemke G, Reber M. Elife. 2017 Mar 14;6. pii: e20470. doi: 10.7554/eLife.20470.
pubmed
 

2015

Top

Estimating the location and size of retinal injections from orthogonal images of an intact retina. Hjorth JJ, Savier E, Sterratt DC, Reber M, Eglen SJ. BMC Neurosci. 2015 Nov 21;16:80. doi: 10.1186/s12868-015-0217-8.
pubmed
Defective response inhibition and collicular noradrenaline enrichment in mice with duplicated retinotopic map in the superior colliculus. Mathis C, Savier E, Bott JB, Clesse D, Bevins N, Sage-Ciocca D, Geiger K, Gillet A, Laux-Biehlmann A, Goumon Y, Lacaud A, Lelièvre V, Kelche C, Cassel JC, Pfrieger FW, Reber M. Brain Struct Funct. 2015;220(3):1573-84. doi: 10.1007/s00429-014-0745-5. Epub 2014 Mar 20.
pubmed
 

2013

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Cellular communication between neurons and glial cells: an overview Pfrieger FW, Reber M. Med Sci (Paris). 2013 Feb;29(2):142-4. doi: 10.1051/medsci/2013292009. Epub 2013 Feb 28.
pubmed
 

2012

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Relevance of exocytotic glutamate release from retinal glia. Slezak M, Grosche A, Niemiec A, Tanimoto N, Pannicke T, Münch TA, Crocker B, Isope P, Härtig W, Beck SC, Huber G, Ferracci G, Perraut M, Reber M, Miehe M, Demais V, Lévêque C, Metzger D, Szklarczyk K, Przewlocki R, Seeliger MW, Sage-Ciocca D, Hirrlinger J, Reichenbach A, Reibel S, Pfrieger FW. Neuron. 2012 May 10;74(3):504-16. doi: 10.1016/j.neuron.2012.03.027.
pubmed
 

2011

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Multifunctionalized electrospun silk fibers promote axon regeneration in central nervous system. Wittmer CR, Claudepierre T, Reber M, Wiedemann P, Garlick JA, Kaplan D, Egles C. Adv Funct Mater. 2011 Nov 22;21(22):4202. Epub 2011 Nov 16.
pubmed
Genetic dissection of EphA receptor signaling dynamics during retinotopic mapping. Bevins N, Lemke G, Reber M. J Neurosci. 2011 Jul 13;31(28):10302-10. doi: 10.1523/JNEUROSCI.1652-11.2011.
pubmed
 

2008

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Implication of neuropilin 2/semaphorin 3F in retinocollicular map formation. Claudepierre T, Koncina E, Pfrieger FW, Bagnard D, Aunis D, Reber M. Dev Dyn. 2008 Nov;237(11):3394-403. doi: 10.1002/dvdy.21759.
pubmed
 

2007

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Eph receptors and ephrin ligands in axon guidance. Reber M, Hindges R, Lemke G. Adv Exp Med Biol. 2007;621:32-49. doi: 10.1007/978-0-387-76715-4_3.
pubmed
 

2005

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Retinotectal mapping: new insights from molecular genetics. Lemke G, Reber M. Annu Rev Cell Dev Biol. 2005;21:551-80.
pubmed
vHnf1 regulates specification of caudal rhombomere identity in the chick hindbrain. Aragón F, Vázquez-Echeverría C, Ulloa E, Reber M, Cereghini S, Alsina B, Giraldez F, Pujades C. Dev Dyn. 2005 Nov;234(3):567-76.
pubmed
 

2004

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A relative signalling model for the formation of a topographic neural map. Reber M, Burrola P, Lemke G. Nature. 2004 Oct 14;431(7010):847-53.
pubmed
 

2003

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Functions of HNF1 family members in differentiation of the visceral endoderm cell lineage. Haumaitre C, Reber M, Cereghini J Biol Chem. 2003 Oct 17;278(42):40933-42. Epub 2003 Jul 14.
pubmed
 

2002

Top

The onecut transcription factor HNF6 is required for normal development of the biliary tract. Clotman F, Lannoy VJ, Reber M, Cereghini S, Cassiman D, Jacquemin P, Roskams T, Rousseau GG, Lemaigre FP. Development. 2002 Apr;129(8):1819-28.
pubmed
 

2001

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Variant hepatocyte nuclear factor 1 expression in the mouse genital tract. Reber M, Cereghini S. Mech Dev. 2001 Jan;100(1):75-8.
pubmed
 

1999

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Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification. Barbacci E, Reber M, Ott MO, Breillat C, Huetz F, Cereghini S. Development. 1999 Nov;126(21):4795-805.
pubmed