NoLogo: a new statistical model highlights the diversity and suggests new classes of Crm1-dependent nuclear export signals.

Liku ME, Legere EA, Moses AM

BMC Bioinformatics 2018 02 27; 19(1):65

PMID: 29482494


Crm1-dependent Nuclear Export Signals (NESs) are clusters of alternating hydrophobic and non-hydrophobic amino acid residues between 10 to 15 amino acids in length. NESs were largely thought to follow simple consensus patterns, based on which they were categorized into 6-10 classes. However, newly discovered NESs often deviate from the established consensus patterns. Thus, identifying NESs within protein sequences remains a bioinformatics challenge.