Rutsuko Ito

faculty_img Academic Title: Associate Professor

Campus: UTSC

CSB Appointment: Full

Primary Undergraduate Department:
Department of Psychology, UTSC

Graduate Programs:
Psychology
Neuroscience
Cell & Systems Biology

Titles and Honors
Academic or Administrative Appointments:

Education:
Ph.D. University of Cambridge 2001
BA, University of Oxford 1997

 

Mailing Address
Department of Department of Psychology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4
Canada

 

Contact Information
Office phone: 416-208-2907
Office: SW 627
Lab:
Lab phone:
Email: rito@utsc.utoronto.ca
URL: http://www.utsc.utoronto.ca/~rito/

 

Research Areas
Systems Biology
Psychology & Behavior
Neurobiology
Animal Biology

 

Research

My lab is primarily interested in investigating the neural and neurochemical mechanisms that underlie conditioned and affective influences upon approach-avoidance decision making, with a particular focus on the role of the affective cortico-limbic-striatal system and its interactions with midbrain dopaminergic systems. Crucially, a central tenet of the research is the notion that conditioned (incentive and affective) cues can take aberrant control over behaviour in psychological disorders such as drug addiction, schizophrenia, and depression. We use a multidisciplinary approach to achieve our research goals. As well as using traditional behavioural neuroscience techniques (intra-cerebral drug micro infusions), we use cutting edge techniques (chemogenetics, optogenetics), and pharmacological models of addiction, schizophrenia and addiction, in combination with novel behavioural paradigms.

 

Publications

 

 

2018

Top

Ventral Hippocampal CA1 and CA3 Differentially Mediate Learned Approach-Avoidance Conflict Processing. Schumacher A, Villaruel FR, Ussling A, Riaz S, Lee ACH, Ito R. Curr Biol. 2018 Apr 23;28(8):1318-1324.e4. doi: 10.1016/j.cub.2018.03.012. Epub 2018 Apr 5.
pubmed
 

2017

Top

Ventral, but not dorsal, hippocampus inactivation impairs reward memory expression and retrieval in contexts defined by proximal cues. Riaz S, Schumacher A, Sivagurunathan S, Van Der Meer M, Ito R. Hippocampus. 2017 Jul;27(7):822-836. doi: 10.1002/hipo.22734. Epub 2017 May 8.
pubmed
Caudal Nucleus Accumbens Core Is Critical in the Regulation of Cue-Elicited Approach-Avoidance Decisions. Hamel L, Thangarasa T, Samadi O, Ito R. eNeuro. 2017 Feb 15;4(1). pii: ENEURO.0330-16.2017. doi: 10.1523/ENEURO.0330-16.2017. eCollection 2017 Jan-Feb.
pubmed
 

2016

Top

The role of the hippocampus in approach-avoidance conflict decision-making: Evidence from rodent and human studies. Ito R, Lee AC. Behav Brain Res. 2016 Oct 15;313:345-57. doi: 10.1016/j.bbr.2016.07.039. Epub 2016 Jul 25.
pubmed
Different dosing regimens of repeated ketamine administration have opposite effects on novelty processing in rats. Schumacher A, Sivanandan B, Tolledo EC, Woldegabriel J, Ito R. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Aug 1;69:1-10. doi: 10.1016/j.pnpbp.2016.03.007. Epub 2016 Apr 8.
pubmed
The ventral hippocampus, but not the dorsal hippocampus is critical for learned approach-avoidance decision making. Schumacher A, Vlassov E, Ito R. Hippocampus. 2016 Apr;26(4):530-42. doi: 10.1002/hipo.22542. Epub 2015 Oct 23.
pubmed
 

2015

Top

Aberrant approach-avoidance conflict resolution following repeated cocaine pre-exposure. Nguyen D, Schumacher A, Erb S, Ito R. Psychopharmacology (Berl). 2015 Oct;232(19):3573-83. doi: 10.1007/s00213-015-4006-y. Epub 2015 Jul 10.
pubmed
Examining the Role of the Human Hippocampus in Approach-Avoidance Decision Making Using a Novel Conflict Paradigm and Multivariate Functional Magnetic Resonance Imaging. O’Neil EB, Newsome RN, Li IH, Thavabalasingam S, Ito R, Lee AC. J Neurosci. 2015 Nov 11;35(45):15039-49. doi: 10.1523/JNEUROSCI.1915-15.2015.
pubmed
 

2014

Top

Excitotoxic lesions of the infralimbic, but not prelimbic cortex facilitate reversal of appetitive discriminative context conditioning: the role of the infralimbic cortex in context generalization. Ashwell R, Ito R. Front Behav Neurosci. 2014 Feb 28;8:63. doi: 10.3389/fnbeh.2014.00063. eCollection 2014.
pubmed
Opposing roles of prelimbic and infralimbic dopamine in conditioned cue and place preference. Hayen A, Meese-Tamuri S, Gates A, Ito R. Psychopharmacology (Berl). 2014 Jun;231(12):2483-92. doi: 10.1007/s00213-013-3414-0. Epub 2014 Jan 16.
pubmed
 

2012

Top

Reward cues in space: commonalities and differences in neural coding by hippocampal and ventral striatal ensembles. Lansink CS, Jackson JC, Lankelma JV, Ito R, Robbins TW, Everitt BJ, Pennartz CM. J Neurosci. 2012 Sep 5;32(36):12444-59.
pubmed
 

2011

Top

The hippocampal-striatal axis in learning, prediction and goal-directed behavior. Pennartz CM, Ito R, Verschure PF, Battaglia FP, Robbins TW. Trends Neurosci. 2011 Oct;34(10):548-59. doi: 10.1016/j.tins.2011.08.001. Epub 2011 Sep 1.
pubmed
Opposing roles of nucleus accumbens core and shell dopamine in the modulation of limbic information processing. Ito R, Hayen A. J Neurosci. 2011 Apr 20;31(16):6001-7. doi: 10.1523/JNEUROSCI.6588-10.2011.
pubmed
Amphetamine exposure selectively enhances hippocampus-dependent spatial learning and attenuates amygdala-dependent cue learning. Ito R, Canseliet M. Neuropsychopharmacology. 2010 Jun;35(7):1440-52. doi: 10.1038/npp.2010.14. Epub 2010 Mar 3.
pubmed
 

2009

Top

Corticostriatal Interactions during Learning, Memory Processing, and Decision Making. Pennartz CM, Berke JD, Graybiel AM, Ito R, Lansink CS, van der Meer M, Redish AD, Smith KS, Voorn P. J Neurosci. 2009 Oct 14;29(41):12831-8. doi: 10.1523/JNEUROSCI.3177-09.2009.
pubmed
 

2008

Top

Functional interaction between the hippocampus and nucleus accumbens shell is necessary for the acquisition of appetitive spatial context conditioning. Ito R, Robbins TW, Pennartz CM, Everitt BJ. J Neurosci. 2008 Jul 2;28(27):6950-9. doi: 10.1523/JNEUROSCI.1615-08.2008.
pubmed
 

2006

Top

Selective excitotoxic lesions of the hippocampus and basolateral amygdala have dissociable effects on appetitive cue and place conditioning based on path integration in a novel Y-maze procedure. Ito R, Robbins TW, McNaughton BL, Everitt BJ. Eur J Neurosci. 2006 Jun;23(11):3071-80.
pubmed
 

2005

Top

The hippocampus and appetitive Pavlovian conditioning: effects of excitotoxic hippocampal lesions on conditioned locomotor activity and autoshaping. Ito R, Everitt BJ, Robbins TW. Hippocampus. 2005;15(6):713-21.
pubmed
 

2004

Top

Differential control over cocaine-seeking behavior by nucleus accumbens core and shell. Ito R, Robbins TW, Everitt BJ. Nat Neurosci. 2004 Apr;7(4):389-97. Epub 2004 Mar 21.
pubmed
 

2002

Top

Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue. Ito R, Dalley JW, Robbins TW, Everitt BJ. J Neurosci. 2002 Jul 15;22(14):6247-53.
pubmed
 

2000

Top

Dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats. Ito R, Dalley JW, Howes SR, Robbins TW, Everitt BJ. J Neurosci. 2000 Oct 1;20(19):7489-95.
pubmed