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CSB Departmental Seminar – Professor Stephen Rogers, University of North Carolina at Chapel Hill

March 22 @ 11:00 am - 12:00 pm

CSB Departmental Seminar

Professor Stephen Rogers,

University of North Carolina

“Control of mechanosensation in Drosophila by the microtubule acetylase dTAT”

Friday March 22, 2019
11:00 a.m. – 12:00 p.m. at RW 432
Host:
Professor Joshua Currie
josh.currie@utoronto.ca
Abstract:

At the cellular level, α-tubulin acetylation alters the structure of microtubules to render them mechanically resistant to compressive forces. How this biochemical property of microtubule acetylation relates to mechanosensation remains unknown, though prior studies have shown that microtubule acetylation plays a role in touch perception. Here, we identify the major Drosophila α-tubulin acetylase (dTAT) and show that it plays key roles in several forms of mechanosensation while exerting little effect on other sensory modalities. dTAT is highly expressed in neurons of the larval peripheral nervous system (PNS) but is not required for normal neuronal morphogenesis. We show that mutation of the acetylase gene or the K40 acetylation site in α-tubulin impairs mechanical sensitivity in sensory neurons and behavioral responses to gentle touch, harsh touch, gravity, and sound stimulus, but not thermal stimulus. Finally, we show that dTAT is required for mechanically-induced activation of NOMPC, a microtubule-associated transient receptor potential channel, and functions to maintain integrity of the microtubule cytoskeleton in response to mechanical stimulation.

Details

Date:
March 22
Time:
11:00 am - 12:00 pm

Venue

Ramsay Wright Building, Room 432
25 Harbord St.
Toronto, ON M5S 3G5 Canada

Organizer

University of Toronto, Cell & Systems Biology