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PhD Transfer Exam – Derek Seto (Desveaux lab)
May 11, 2017 @ 2:00 pm - 2:30 pm
PhD Transfer Exam
Thursday May 11th, 2:10 pm – Earth Sciences Centre, Rm. 3087
Derek Seto (Desveaux lab)
“Recognition of the Pseudomonas syringae type III effector HopF2a by the Arabidopsis R protein ZAR1“
The plant pathogen Pseudomonas syringae uses effector proteins to disrupt plant immune pathways, allowing for successful colonization. However, plants have evolved resistance (R) proteins that detect the presence of some effectors, and subsequently trigger an immune response that suppresses pathogen growth. Recognition of effectors by R proteins often involves monitoring another host protein for effector-induced molecular perturbations; upon detection of these modifications, an immune response is triggered. The effector HopF2a from P. syringae pv. aceris M302273PT has been found to trigger immunity in Arabidopsis. Recognition of HopF2a has been shown to require the R gene ZAR1, as well as ZRK3, which encodes for a kinase. The R protein ZAR1 is also involved in the recognition of two other unrelated T3SEs: HopZ1a from P. syringae pv. syringae and AvrAC from Xanthamonas campestris pv. campestris. These also require kinases from the same family as ZRK3 for their recognition: ZED1 and ZRK1, respectively. In addition to this, AvrAC requires the PBL2 kinase for its recognition as well. The objectives of this research are to identify other potential genetic requirements for HopF2a recognition in Arabidopsis, and to understand how these components are involved in the HopF2a recognition mechanism. The results of this project will show how a single R protein is able to recognize several unrelated effectors by associating with different members of a diverse family of kinases. In turn, this can demonstrate how plants can potentially defend themselves against a wide variety of pathogens.