Ted Erclik

faculty_img Academic Title: Assistant Professor

Campus: UTM

CSB Appointment: Full

Primary Undergraduate Department:
Biology

Graduate Programs:
Cell & Systems Biology
Developmental Biology

Education: PhD – University of Toronto 2007

 

Mailing Address
Department of Biology
University of Toronto – Mississauga
3359 Mississauga Road North
Mississauga, ON L5L 1C6
Canada
 

 

Contact Information
Office phone: 905-569-5755 
Office: DV 3046 
Lab: DV 2026 
Lab phone:  
Email: ted.erclik@utoronto.ca 
URL: http://www.utm.utoronto.ca/biology/people/erclik-ted

 

Research Areas
Developmental Biology
Neurobiology
Molecular Biology
Genetics

 

Research

Our lab’s goal is to understand how complex neural circuits develop from an initial population of stem cells. Current projects in the lab investigate (1) the mechanisms by which neural stem cells generate diversity and (2) the rules that govern the reorganization of neurons during circuit development. As a model system, we use the Drosophila optic lobe, which is the visual processing center of the fruit fly brain. Recent advances in the tools available to Drosophila neurobiologists, including the ability to label and genetically manipulate single stem cells and neurons, make the fly brain an ideal system in which to study neural circuit development. Additionally, the striking similarities shared between the optic lobe and the mammalian neuroretina, in both their modes of neurogenesis and organization, make findings in the optic lobe especially relevant to our understanding of human visual system development and disease.

 

Publications

 


2017

Top

Integration of temporal and spatial patterning generates neural diversity. Erclik T, Li X, Courgeon M, Bertet C, Chen Z, Baumert R, Ng J, Koo C, Arain U, Behnia R, del Valle Rodriguez A, Senderowicz L, Negre N, White KP, Desplan C. Nature. 2017 Jan 19;541(7637):365-370. doi: 10.1038/nature20794. Epub 2017 Jan 11.
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2016

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A Unique Class of Neural Progenitors in the Drosophila Optic Lobe Generates Both Migrating Neurons and Glia. Chen Z, Del Valle Rodriguez A, Li X, Erclik T, Fernandes VM, Desplan C. Cell Rep. 2016 Apr 14. pii: S2211-1247(16)30332-1. doi: 10.1016/j.celrep.2016.03.061. [Epub ahead of print]
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2014

Top

Temporal patterning of neuroblasts controls Notch-mediated cell survival through regulation of Hid or Reaper. Bertet C, Li X, Erclik T, Cavey M, Wells B, Desplan C. Cell. 2014 Aug 28;158(5):1173-86. doi: 10.1016/j.cell.2014.07.045.
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2013

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Temporal patterning of Drosophila medulla neuroblasts controls neural fates. Pell LG, Li X, Erclik T, Bertet C, Chen Z, Voutev R, Venkatesh S, Morante J, Celik A, Desplan C. Nature. 2013 Jun 27;498(7455):456-62. doi: 10.1038/nature12319. Epub 2013 Jun 19.
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2011

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Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6. Pell LG, Morante J, Erclik T, Desplan C. Development. 2011 Feb;138(4):687-93. doi: 10.1242/dev.056069. Epub 2011 Jan 5.
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2009

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Eye evolution at high resolution: the neuron as a unit of homology. Erclik T, Hartenstein V, McInnes RR, Lipshitz HD. Dev Biol. 2009 Aug 1;332(1):70-9. doi: 10.1016/j.ydbio.2009.05.565. Epub 2009 May 23. Review.
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2008

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Conserved role of the Vsx genes supports a monophyletic origin for bilaterian visual systems. Erclik T, Hartenstein V, Lipshitz HD, McInnes RR. Curr Biol. 2008 Sep 9;18(17):1278-87. doi: 10.1016/j.cub.2008.07.076. Epub 2008 Aug 28.
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2007

Top

Specification and development of the pars intercerebralis and pars lateralis, neuroendocrine command centers in the Drosophila brain. de Velasco B, Erclik T, Shy D, Sclafani J, Lipshitz H, McInnes R, Hartenstein V. Dev Biol. 2007 Feb 1;302(1):309-23. Epub 2006 Sep 26.
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