Vincent Tropepe
Professor and Vice Dean, Research
Campus
St. George (downtown)
CSB Appointment
Full
Research Areas
Animal Biology, Cell Biology, Developmental Biology, Genetics / Genomics, Molecular Biology, Neurobiology, Systems Biology
Education
Ph.D. University of Toronto 2000
B.Sc. McMaster University 1994
Primary Undergraduate Department
Cell & Systems Biology
Graduate Programs
Cell & Systems Biology
Academic or Administrative Appointments
Vice-Dean, Research (Faculty of Arts & Science)
Research Description
The production of nerve cells (neurogenesis) is a life-long process with regional specialization that is critical for the formation of distinct functional domains in the vertebrate nervous system. Moreover, neurogenesis in the mature nervous system may contribute to the structural changes that underlie neural plasticity, which is crucial for sensory processing and behaviour. My lab investigates how neurogenesis contributes to the generation and maintenance of regional nerve cell diversity throughout life. We utilize various molecular genetic techniques in order to identify and characterize the molecular mechanisms that govern vertebrate neurogenesis.
Contact Information
Office Phone: 416-946-0338
Office: RW618A
Lab: RW607/RW618/RW619
Lab Phone: 416-946-0593 / 416-946-7218
Email
Mailing Address
Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
Canada
Recent News
Publications
2021
Usher syndrome type 1-associated gene, pcdh15b, is required for photoreceptor structural integrity in zebrafish
Miles A, Blair C, Emili A, Tropepe V
2021, Disease Models & Mechanisms, 10.1242/dmm.048965
2018
The role of neuro-epithelial-like and radial-glial stem and progenitor cells in development, plasticity, and repair.
Lindsey BW, Hall ZJ, Heuzé A, Joly JS, Tropepe V, Kaslin J
2018, Progress in neurobiology, 170, 99-114, 29902500
Movement maintains forebrain neurogenesis via peripheral neural feedback in larval zebrafish.
Hall ZJ, Tropepe V
2018, eLife, 7, 29528285
2017
Cone-like rhodopsin expressed in the all-cone retina of the colubrid pine snake as a potential adaptation to diurnality.
Bhattacharyya N, Darren B, Schott RK, Tropepe V, Chang BSW
2017, The Journal of experimental biology, 220, 2418-2425, 28468872
2016
A second visual rhodopsin gene, rh1-2, is expressed in zebrafish photoreceptors and found in other ray-finned fishes.
Morrow JM, Lazic S, Dixon Fox M, Kuo C, Schott RK, de A Gutierrez E, Santini F, Tropepe V, Chang BS
2017, The Journal of experimental biology, 220, 294-303, 27811293
G9a and ZNF644 Physically Associate to Suppress Progenitor Gene Expression during Neurogenesis.
Olsen JB, Wong L, Deimling S, Miles A, Guo H, Li Y, Zhang Z, Greenblatt JF, Emili A, Tropepe V
2016, Stem cell reports, 7, 454-470, 27546533
2015
Evolutionary transformation of rod photoreceptors in the all-cone retina of a diurnal garter snake.
Schott RK, Müller J, Yang CG, Bhattacharyya N, Chan N, Xu M, Morrow JM, Ghenu AH, Loew ER, Tropepe V, Chang BS
2016, Proceedings of the National Academy of Sciences of the United States of America, 113, 356-61, 26715746
Nonsense mutation in the WDR73 gene is associated with Galloway-Mowat syndrome.
Ben-Omran T, Fahiminiya S, Sorfazlian N, Almuriekhi M, Nawaz Z, Nadaf J, Khadija KA, Zaineddin S, Kamel H, Majewski J, Tropepe V
2015, Journal of medical genetics, 52, 381-90, 25873735
Mutual antagonism of the paired-type homeobox genes, vsx2 and dmbx1, regulates retinal progenitor cell cycle exit upstream of ccnd1 expression.
Wong L, Power N, Miles A, Tropepe V
2015, Developmental biology, 402, 216-28, 25872183
2014
Changes in the social environment induce neurogenic plasticity predominantly in niches residing in sensory structures of the zebrafish brain independently of cortisol levels
Lindsey BW, Tropepe V
2014, Developmental neurobiology, 24753454
Casting a wider fish net on animal models in neuropsychiatric research
Hall ZJ, De Serrano AR, Rodd FH, Tropepe V
2014, Progress in neuro-psychopharmacology & biological psychiatry, 24726811
2012
Cockayne syndrome b maintains neural precursor function
Sacco R, Tamblyn L, Rajakulendran N, Bralha FN, Tropepe V, Laposa RR
2013, DNA repair, 12, 110-20, 23245699
Toll-like signaling and the cytokine IL-6 regulate histone deacetylase dependent neuronal survival
Forgione N, Tropepe V
2012, PloS one, 7, e41033, 22848425
The cellular composition of neurogenic periventricular zones in the adult zebrafish forebrain
Lindsey BW, Darabie A, Tropepe V
2012, The Journal of comparative neurology, 520, 2275-316, 22318736
Zfhx1b induces a definitive neural stem cell fate in mouse embryonic stem cells
Dang LT, Wong L, Tropepe V
2012, Stem cells and development, 21, 2838-51, 22594450
2011
Histone deacetylase inhibition promotes Caspase-independent cell death of ventral midbrain neurons
Forgione N, Tropepe V
2011, Molecular and cellular neurosciences, 48, 117-28, 21763771
The PI3K/Akt/mTOR pathway mediates retinal progenitor cell survival under hypoxic and superoxide stress
Sanghera KP, Mathalone N, Baigi R, Panov E, Wang D, Zhao X, Hsu H, Wang H, Tropepe V, Ward M, Boyd SR
2011, Molecular and cellular neurosciences, 47, 145-53, 21463685
Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae
Souza BR, Romano-Silva MA, Tropepe V
2011, The Journal of neuroscience : the official journal of the Society for Neuroscience, 31, 5512-25, 21471388
The role of dopaminergic signalling during larval zebrafish brain development: a tool for investigating the developmental basis of neuropsychiatric disorders
Souza BR, Tropepe V
2011, Reviews in the neurosciences, 22, 107-19, 21615265
2010
Waste management and adult neurogenesis
Mattocks M, Tropepe V
2010, Cell stem cell, 7, 421-2, 20887944
Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development
Wong L, Weadick CJ, Kuo C, Chang BS, Tropepe V
2010, BMC developmental biology, 10, 100, 20860823
FGF dependent regulation of Zfhx1b gene expression promotes the formation of definitive neural stem cells in the mouse anterior neurectoderm
Dang LT, Tropepe V
2010, Neural development, 5, 13, 20459606
2009
Neurogenic potential of isolated precursor cells from early post-gastrula somitic tissue
Tropepe V, Alton K, Sachewsky N, Cheng V, Kuo C, Morshead CM
2009, Stem cells and development, 18, 1533-42, 19326969
2007
Kinship and Descent: Redefining the Stem Cell Compartment in the Adult Hippocampus
Tropepe V
2007, Cell stem cell, 1, 481-483, 18371384
Kinship and descent: redefining the stem cell compartment in the adult hippocampus
Tropepe V
2007, Cell stem cell, 1, 481-3, 18938741
A comparative framework for understanding the biological principles of adult neurogenesis
Lindsey BW, Tropepe V
2006, Progress in neurobiology, 80, 281-307, 17218052
2006
Neural induction and neural stem cell development
Dang L, Tropepe V
2006, Regenerative medicine, 1, 635-52, 17465732
Genomic sequence and spatiotemporal expression comparison of zebrafish mbx1 and its paralog, mbx2
Chang L, Khoo B, Wong L, Tropepe V
2006, Development genes and evolution, 216, 647-54, 16733737
2005
Identification of a BMP inhibitor-responsive promoter module required for expression of the early neural gene zic1
Tropepe V, Li S, Dickinson A, Gamse JT, Sive HL
2006, Developmental biology, 289, 517-29, 16307736
2002
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells
Hitoshi S, Alexson T, Tropepe V, Donoviel D, Elia AJ, Nye JS, Conlon RA, Mak TW, Bernstein A, van der Kooy D
2002, Genes & development, 16, 846-58, 11937492