BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//wp-events-plugin.com//7.3.3//EN
TZID:America/Toronto
X-WR-TIMEZONE:America/Toronto
BEGIN:VEVENT
UID:27@csb.utoronto.ca
DTSTART;TZID=America/Toronto:20251212T110000
DTEND;TZID=America/Toronto:20251212T120000
DTSTAMP:20251209T223452Z
URL:https://csb.utoronto.ca/events/csb-seminar-christopher-grefen-phd-ruhr
 -university-bochum/
SUMMARY:Christopher Grefen\, PhD - Ruhr-University Bochum  -- CSB Seminar
DESCRIPTION:CSB Departmental Seminar\nFriday\, December 12th @ 11:00 am\nSP
 EAKER: Christopher Grefen\, PhD - Ruhr-University Bochum\nTITLE: Insertion
  pathways for membrane proteins in the plant ER\nABSTRACT: Membrane protei
 ns are essential for almost every cellular process\, yet the routes they t
 ake to reach the endoplasmic reticulum (ER) are surprisingly diverse. Whil
 e many follow the classical SRP/Sec61 pathway\, a growing number rely on a
 lternative\, non-canonical routes. These include tail-anchored (TA) protei
 ns and other SRP-lacking proteins with internal transmembrane domains that
  Sec61 cannot efficiently handle.\nIn this talk\, I will share recent find
 ings from Arabidopsis thaliana that combine mechanistic insights into the 
 Guided-Entry of TA proteins (GET) pathway with the organism-level conseque
 nces of pathway loss. I will show how specific lipid species influence GET
  receptor function and how impaired insertion affects development\, tissue
  differentiation\, and stress responses. Finally\, I will present unpublis
 hed data on the SRP-independent (SND) pathway\, revealing how its loss dis
 rupts fertility and why plants rely on this alternative route for proper r
 eproductive development.\n\nHOST: Heather McFarlane\nLOCATION: Cell and S
 ystems Biology\, 25 Harbord Street\, Suite 432\nLIVESTREAM LINK: https://
 csb.utoronto.ca/live-stream/
CATEGORIES:seminar
END:VEVENT
BEGIN:VTIMEZONE
TZID:America/Toronto
X-LIC-LOCATION:America/Toronto
BEGIN:STANDARD
DTSTART:20251102T010000
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
END:STANDARD
END:VTIMEZONE
END:VCALENDAR