BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//wp-events-plugin.com//7.2.3.1//EN
TZID:America/Toronto
X-WR-TIMEZONE:America/Toronto
BEGIN:VEVENT
UID:9@csb.utoronto.ca
DTSTART;TZID=America/Toronto:20251205T110000
DTEND;TZID=America/Toronto:20251205T120000
DTSTAMP:20251121T205507Z
URL:https://csb.utoronto.ca/events/csb-seminar-ingo-braasch-phd-michigan-s
 tate-university/
SUMMARY:Ingo Braasch\, PhD - Michigan State University -- CSB Seminar
DESCRIPTION:CSB Departmental Seminar\nFriday\, December 5th @ 11:00 am\nSPE
 AKER: Ingo Braasch\, PhD - Michigan State University\nTITLE: A Blast From 
 the Past: ‘Living Fossils’ Bridge Gene Regulation Across Long Evolutio
 nary Distances in Vertebrates\nABSTRACT: Identifying cis-regulatory elemen
 ts (CREs) across distant vertebrate lineages remains a major challenge. Ma
 ny CREs are undetectable across taxa due to sequence divergence beyond rec
 ognition\, CRE turnover\, and the emergence of lineage-specific regulatory
  elements. This disconnect is especially pronounced in widely used model s
 ystems like rodents and teleost fishes\, which exhibit rapid molecular seq
 uence evolution.\nTeleosts\, including key biomedical models like zebrafis
 h\, are often used to study vertebrate genome function and regulation. How
 ever\, a lineage-specific teleost genome duplication (TGD) drastically res
 haped their genome structure and regulatory networks. Their accelerated se
 quence evolution\, likely driven by the TGD\, has obscured many ancestral 
 CREs\, complicating efforts to trace the evolution of gene regulation acro
 ss vertebrates.\nIn contrast\, holostean fishes – gars (genera Lepisoste
 us and Atractosteus) and bowfins (genus Amia) – retain some of the slowe
 st-evolving genomes among vertebrates. These “living fossils” provide 
 a unique window into early bony vertebrate evolution. Their unduplicated g
 enomes\, conserved development\, and archaic morphologies offer critical i
 nsight into deep homologies that have been masked by rapid evolution in th
 e derived teleost and tetrapod lineages.\nLeveraging haplotype-resolved ge
 nome assemblies from multiple holostean species we use comparative genomic
 s\, single-cell transcriptomics\, and epigenomic profiling in holosteans t
 o reveal ancestral CREs and recover hidden gene regulatory landscapes acro
 ss bony vertebrates. The evolutionary stability of holostean genomes enabl
 es the identification of conserved vertebrate CREs that would otherwise re
 main hidden for fast-evolving taxa. Our work underscores the immense value
  of including slow-evolving lineages across the Vertebrate Tree of Life to
  reconstruct the deep history of gene regulation and uncover the genome re
 gulatory logic that shapes vertebrate biodiversity.\n\nHOST: Max Shafer\nL
 OCATION: Cell and Systems Biology\, 25 Harbord Street\, Suite 432\nLIVEST
 REAM LINK: https://csb.utoronto.ca/live-stream/
CATEGORIES:seminar
END:VEVENT
BEGIN:VTIMEZONE
TZID:America/Toronto
X-LIC-LOCATION:America/Toronto
BEGIN:STANDARD
DTSTART:20251102T010000
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
END:STANDARD
END:VTIMEZONE
END:VCALENDAR