Danesh Moazed, PhD – Department of Cell Biology, Harvard Medical School — CSB Seminar
When
Event Type
CSB Departmental Seminar
Friday, April 17th @ 11:00 am
SPEAKER: Danesh Moazed, PhD – Department of Cell Biology, Harvard Medical School
TITLE: Heterochromatin and Epigenetic Inheritance Mechanisms
ABSTRACT:
The formation of heterochromatin and its faithful inheritance during development and adult life are required for silencing of transposons and lineage-specific cell identity genes. We have developed reporter-based systems that allow us to study the requirements for the establishment of epigenetic maintenance of heterochromatin in fission yeast and mammalian cells. Our work reveals roles for pathways ranging from DNA binding proteins and noncoding RNAs, which mediate specific assembly events, to complexes that mediate the spreading and epigenetic inheritance of heterochromatin. I will discuss our recent results on the roles of specificity factors, RNA decay complexes, and the DNA replication machinery in heterochromatin establishment and maintenance.
HOST: Student invitee – Saltzman Lab
LOCATION: Cell and Systems Biology, 25 Harbord Street, Suite 432
LIVESTREAM LINK: https://csb.utoronto.ca/live-stream/