Judith Mandl, PhD – Department of Physiology, McGill University — CSB Seminar
When
Event Type
CSB Departmental Seminar
Friday, February 20th @ 11:00 am
SPEAKER: Judith Mandl, PhD – Department of Physiology, McGill University
TITLE: Feeling their way to immunity: The emerging role of T cell proprioception
ABSTRACT:
Judith Mandl, PhD, is an Associate Professor in the Department of Physiology at McGill University and currently holds a Tier 2 Canada Research Chair in Immune Cell Dynamics.
Her team studies the complex migration choreography of immune cells that is critical to effective immune responses, with a particular focus on T cells.
Recent work has focused on the specific challenges T cells face as they move through tissues, to what extent nuclear deformability and cytoskeletal processes define how T cells make decisions as they navigate, the consequences of perturbing immune cell migration for T cell function and differentiation, and the specific interactions made by T cells during their migration which leads to heterogeneity in their behaviour.
Her lab applies state-of-the-art microscopy and systems biology tools, using mouse models to link aspects of individual immune cell migratory behaviour to both within-cell cytoskeletal processes and whole organismal-level readouts such as cell differentiation, homeostasis and responses to infection.
HOST: Sergey Plotnikov
LOCATION: Cell and Systems Biology, 25 Harbord Street, Suite 432
LIVESTREAM LINK: https://csb.utoronto.ca/live-stream/