Owen Tamplin, PhD – Department of Cell and Regenerative Biology, University of Wisconsin – Madison — CSB Seminar

CSB Departmental Seminar

Friday, January 16th @ 11:00 am

SPEAKER: Owen Tamplin, PhD – Department of Cell and Regenerative Biology, University of Wisconsin – Madison

TITLE: The blood stem cell microenvironment: development and function across the lifespan

ABSTRACT: Our lab primarily focuses on understanding the hematopoietic stem cell (HSC) niche microenvironment. HSC transplantation is a curative treatment for many blood diseases and cancers, however, many of these procedures still fail and there is a need to improve success rates. Therefore, a better understanding of the signals and adhesion molecules in the HSC microenvironment that regulate engraftment of HSCs after transplantation, and maintain HSCs in an undifferentiated state, are critical for improving clinical HSC therapies. Our lab uses complementary zebrafish and mouse models for in vivo cell biology and translational studies, respectively. We integrate cutting-edge technologies to gain new perspectives on the HSC microenvironment. We are focused on three main areas of research: 1) Understanding the emergence and migration of HSCs between different sites of hematopoiesis in the embryo; 2) Defining the role of neurotransmitters and metabolites in the HSC niche; 3) Generating new animal models for the study of development and disease.

HOST: Felix Gunawan

LOCATION: Cell and Systems Biology, 25 Harbord Street, Suite 432

LIVESTREAM LINK: https://csb.utoronto.ca/live-stream/