Ian Orchard

Professor Emeritus


Campus

UTM

CSB Appointment

Emeritus, Full

Education

Ph.D D.Sc. University of Birmingham, UK
B.Sc. University of Birmingham, UK

Titles and Honors

University of Toronto Distinguished Professor

Primary Undergraduate Department

Biology, UTM

Graduate Programs

Cell & Systems Biology
Genome Biology & Bioinformatics

Academic or Administrative Appointments

Emeritus Professors at UTM

Research Description

We examine the functioning of the nervous system, using insects as experimental models. We establish the mechanisms by which the nervous system communicates; examining hormonal, synaptic, and modulatory mechanism.


Contact Information

Office Phone: 905-569-4751
Office: DV3035
Lab: DV3017A
Lab Phone: 905-569-4752
Email

Mailing Address

Department of Biology
University of Toronto
3359 Mississauga Road
Mississauga, ON L5L 1C6
Canada

Visit lab’s website


Publications

2018

A Rhodnius prolixus Insulin Receptor and Its Conserved Intracellular Signaling Pathway and Regulation of Metabolism

Defferrari MS, Da Silva SR, Orchard I, Lange AB
2018, Frontiers in Endocrinology, 10.3389/fendo.2018.00745

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2014

Structure-activity relationships of two Rhodnius prolixus calcitonin-like diuretic hormone analogs

Zandawala M, Poulos C, Orchard I
2014, Peptides, 24703964

Identification and functional characterization of FGLamide-related allatostatin receptor in Rhodnius prolixus

Zandawala M, Orchard I
2015, Insect biochemistry and molecular biology, 57, 1-10, 25500190

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2013

Isolation and functional characterization of calcitonin-like diuretic hormone receptors in Rhodnius prolixus

Zandawala M, Li S, Hauser F, Grimmelikhuijzen CJ, Orchard I
2013, PloS one, 8, e82466, 24312424

Evidence for a conserved CCAP-signaling pathway controlling ecdysis in a hemimetabolous insect, Rhodnius prolixus

Lee D, Orchard I, Lange AB
2013, Frontiers in neuroscience, 7, 207, 24204330

Molecular characterization and possible biological roles of allatotropin in Rhodnius prolixus

Masood M, Orchard I
2014, Peptides, 53, 159-71, 24177575

Post-feeding physiology in Rhodnius prolixus: the possible role of FGLamide-related allatostatins

Zandawala M, Orchard I
2013, General and comparative endocrinology, 194, 311-7, 24161751

Expression analysis and molecular characterization of aquaporins in Rhodnius prolixus

Staniscuaski F, Paluzzi JP, Real-Guerra R, Carlini CR, Orchard I
2013, Journal of insect physiology, 59, 1140-50, 24035749

The molecular characterization of the kinin transcript and the physiological effects of kinins in the blood-gorging insect, Rhodnius prolixus

Bhatt G, da Silva R, Nachman RJ, Orchard I
2014, Peptides, 53, 148-58, 23624318

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2012

The distribution and physiological effects of the myoinhibiting peptides in the kissing bug, rhodnius prolixus

Lange AB, Alim U, Vandersmissen HP, Mizoguchi A, Vanden Broeck J, Orchard I
2012, Frontiers in neuroscience, 6, 98, 22783161

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2011

Investigation of the potential involvement of eicosanoid metabolites in anti-diuretic hormone signaling in Rhodnius prolixus

Paluzzi JP, Young P, Defferrari MS, Orchard I, Carlini CR, O'Donnell MJ
2012, Peptides, 34, 127-34, 22079222

Cloning of the cDNA, localization, and physiological effects of FGLamide-related allatostatins in the blood-gorging bug, Rhodnius prolixus

Zandawala M, Lytvyn Y, Taiakina D, Orchard I
2012, Insect biochemistry and molecular biology, 42, 10-21, 22061445

The Proctolin Gene and Biological Effects of Proctolin in the Blood-Feeding Bug, Rhodnius prolixus

Orchard I, Lee do H, da Silva R, Lange AB
2011, Frontiers in endocrinology, 2, 59, 22654816

Identification of the elusive peptidergic diuretic hormone in the blood-feeding bug Rhodnius prolixus: a CRF-related peptide

Te Brugge V, Paluzzi JP, Schooley DA, Orchard I
2011, The Journal of experimental biology, 214, 371-81, 21228196

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2010

Identification of kinin-related peptides in the disease vector, Rhodnius prolixus

Te Brugge V, Paluzzi JP, Neupert S, Nachman RJ, Orchard I
2011, Peptides, 32, 469-74, 20934474

Neuropeptide action in insects and crustaceans

Mykles DL, Adams ME, Gäde G, Lange AB, Marco HG, Orchard I
2010, Physiological and biochemical zoology : PBZ, 83, 836-46, 20550437

Isolation and characterization of the cDNA encoding DH(31) in the kissing bug, Rhodnius prolixus

Zandawala M, Paluzzi JP, Orchard I
2011, Molecular and cellular endocrinology, 331, 79-88, 20797422

Effects of the mycotoxin destruxin A on Locusta migratoria visceral muscles

Ruiz-Sanchez E, Lange AB, Orchard I
2010, Toxicon : official journal of the International Society on Toxinology, 56, 1043-51, 20670642

Isolation, expression analysis, and functional characterization of the first antidiuretic hormone receptor in insects

Paluzzi JP, Park Y, Nachman RJ, Orchard I
2010, Proceedings of the National Academy of Sciences of the United States of America, 107, 10290-5, 20479227

Effects of the cyclopeptide mycotoxin destruxin A on the Malpighian tubules of Rhodnius prolixus (Stål)

Ruiz-Sanchez E, Orchard I, Lange AB
2010, Toxicon : official journal of the International Society on Toxinology, 55, 1162-70, 20060849

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2009

The antidiuretic neurohormone RhoprCAPA-2 downregulates fluid transport across the anterior midgut in the blood-feeding insect Rhodnius prolixus

Ianowski JP, Paluzzi JP, Te Brugge VA, Orchard I
2010, American journal of physiology. Regulatory, integrative and comparative physiology, 298, R548-57, 20007522

A second gene encodes the anti-diuretic hormone in the insect, Rhodnius prolixus

Paluzzi JP, Orchard I
2010, Molecular and cellular endocrinology, 317, 53-63, 19931590

Neurohormones implicated in the control of Malpighian tubule secretion in plant sucking heteropterans: The stink bugs Acrosternum hilare and Nezara viridula

Coast GM, TeBrugge VA, Nachman RJ, Lopez J, Aldrich JR, Lange A, Orchard I
2010, Peptides, 31, 468-73, 19772880

Peptides and serotonin control feeding-related events in Rhodnius prolixus

Orchard I
2009, Frontiers in bioscience (Elite edition), 1, 250-62, 19482642

Biological activity of diuretic factors on the anterior midgut of the blood-feeding bug, Rhodnius prolixus

Te Brugge V, Ianowski JP, Orchard I
2009, General and comparative endocrinology, 162, 105-12, 19408362

Diuretic and antidiuretic hormones in the blood-gorging bug Rhodnius prolixus

Orchard I, Paluzzi JP
2009, Annals of the New York Academy of Sciences, 1163, 501-3, 19456399

Invitro effect of Canavalia ensiformis urease and the derived peptide Jaburetox-2Ec on Rhodnius prolixus Malpighian tubules

Stanisçuaski F, Te Brugge V, Carlini CR, Orchard I
2009, Journal of insect physiology, 55, 255-63, 19121321

Physiological activity of neuropeptide f on the hindgut of the blood-feeding hemipteran, Rhodnius prolixus

Gonzalez R, Orchard I
2009, Journal of insect science (Online), 9, 1-14, 20050776

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2008

Isolation, cloning, and expression mapping of a gene encoding an antidiuretic hormone and other CAPA-related peptides in the disease vector, Rhodnius prolixus

Paluzzi JP, Russell WK, Nachman RJ, Orchard I
2008, Endocrinology, 149, 4638-46, 18511504

Amino acid sequence and biological activity of a calcitonin-like diuretic hormone (DH31) from Rhodnius prolixus

Brugge VA, Schooley DA, Orchard I
2008, The Journal of experimental biology, 211, 382-90, 18203994

Differential actions of diuretic factors on the Malpighian tubules of Rhodnius prolixus

Donini A, O'Donnell MJ, Orchard I
2008, The Journal of experimental biology, 211, 42-8, 18083731

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2007

Characterization of neuropeptide F-like immunoreactivity in the blood-feeding hemipteran, Rhodnius prolixus

Gonzalez R, Orchard I
2008, Peptides, 29, 545-58, 18201798

Insect neuroendocrinology in the post-genomic era

Nässel D, Orchard I
2007, General and comparative endocrinology, 153, 57-8, 17666203

Isolation and sequencing of two FMRFamide-related peptides from the gut of Locusta migratoria L

Hill SR, Orchard I
2007, Peptides, 28, 1490-7, 17707763

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2006

Distribution, activity and evidence for the release of an anti-diuretic peptide in the kissing bug Rhodnius prolixus

Paluzzi JP, Orchard I
2006, The Journal of experimental biology, 209, 907-15, 16481579

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2005

Serotonin: a coordinator of feeding-related physiological events in the blood-gorging bug, Rhodnius prolixus

Orchard I
2006, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 144, 316-24, 16377224

The distribution and activity of tachykinin-related peptides in the blood-feeding bug, Rhodnius prolixus

Kwok R, Chung D, Brugge VT, Orchard I
2005, Peptides, 26, 43-51, 15626503

In vitro analysis of the digestive enzymes amylase and alpha-glucosidase in the midguts of Locusta migratoria L. in response to the myosuppressin, SchistoFLRFamide

Hill SR, Orchard I
2005, Journal of insect physiology, 51, 1-9, 15686640

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2004

The influence of diet and feeding state on FMRFamide-related peptides in the gut of Locusta migratoria L

Hill SR, Orchard I
2004, Peptides, 25, 105-14, 15003362

The effects of dopamine agonists and antagonists on the secretory responses in the salivary glands of the locust (Locusta migratoria)

Keating C, Orchard I
2004, Journal of insect physiology, 50, 17-23, 15037089

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2003

FMRFamide-related peptides in the gut of Locusta migratoria L.: a comprehensive map and developmental profile

Hill SR, Orchard I
2003, Peptides, 24, 1511-24, 14706530

The distribution and effects of Dippu-allatostatin-like peptides in the blood-feeding bug, Rhodnius prolixus

Sarkar NR, Tobe SS, Orchard I
2003, Peptides, 24, 1553-62, 14706534

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2002

Central effects of the peptides, SchistoFLRFamide and proctolin, on locust oviduct contraction

Kwok R, Orchard I
2002, Peptides, 23, 1925-32, 12431730

Characterization of a putative SchistoFLRFamide receptor in the CNS of Locusta migratoria

Kwok R, Orchard I
2002, Peptides, 23, 765-72, 11897396

Contractions associated with the salivary glands of the blood-feeding bug, Rhodnius prolixus: evidence for both a neural and neurohormonal coordination

Orchard I, Brugge VT
2002, Peptides, 23, 693-700, 11897388

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