Ian Orchard
Professor Emeritus
Campus
UTM
CSB Appointment
Emeritus, Full
Education
Ph.D D.Sc. University of Birmingham, UK
B.Sc. University of Birmingham, UK
Titles and Honors
University of Toronto Distinguished Professor
Primary Undergraduate Department
Biology, UTM
Graduate Programs
Cell & Systems Biology
Genome Biology & Bioinformatics
Academic or Administrative Appointments
Emeritus Professors at UTM
Research Description
We examine the functioning of the nervous system, using insects as experimental models. We establish the mechanisms by which the nervous system communicates; examining hormonal, synaptic, and modulatory mechanism.
Contact Information
Office Phone: 905-569-4751
Office: DV3035
Lab: DV3017A
Lab Phone: 905-569-4752
Email
Mailing Address
Department of Biology
University of Toronto
3359 Mississauga Road
Mississauga, ON L5L 1C6
Canada
Publications
2018
A Rhodnius prolixus Insulin Receptor and Its Conserved Intracellular Signaling Pathway and Regulation of Metabolism
Defferrari MS, Da Silva SR, Orchard I, Lange AB
2018, Frontiers in Endocrinology, 10.3389/fendo.2018.00745
2014
Structure-activity relationships of two Rhodnius prolixus calcitonin-like diuretic hormone analogs
Zandawala M, Poulos C, Orchard I
2014, Peptides, 24703964
Identification and functional characterization of FGLamide-related allatostatin receptor in Rhodnius prolixus
Zandawala M, Orchard I
2015, Insect biochemistry and molecular biology, 57, 1-10, 25500190
2013
Isolation and functional characterization of calcitonin-like diuretic hormone receptors in Rhodnius prolixus
Zandawala M, Li S, Hauser F, Grimmelikhuijzen CJ, Orchard I
2013, PloS one, 8, e82466, 24312424
Evidence for a conserved CCAP-signaling pathway controlling ecdysis in a hemimetabolous insect, Rhodnius prolixus
Lee D, Orchard I, Lange AB
2013, Frontiers in neuroscience, 7, 207, 24204330
Molecular characterization and possible biological roles of allatotropin in Rhodnius prolixus
Masood M, Orchard I
2014, Peptides, 53, 159-71, 24177575
Post-feeding physiology in Rhodnius prolixus: the possible role of FGLamide-related allatostatins
Zandawala M, Orchard I
2013, General and comparative endocrinology, 194, 311-7, 24161751
Expression analysis and molecular characterization of aquaporins in Rhodnius prolixus
Staniscuaski F, Paluzzi JP, Real-Guerra R, Carlini CR, Orchard I
2013, Journal of insect physiology, 59, 1140-50, 24035749
The molecular characterization of the kinin transcript and the physiological effects of kinins in the blood-gorging insect, Rhodnius prolixus
Bhatt G, da Silva R, Nachman RJ, Orchard I
2014, Peptides, 53, 148-58, 23624318
2012
The distribution and physiological effects of the myoinhibiting peptides in the kissing bug, rhodnius prolixus
Lange AB, Alim U, Vandersmissen HP, Mizoguchi A, Vanden Broeck J, Orchard I
2012, Frontiers in neuroscience, 6, 98, 22783161
2011
Investigation of the potential involvement of eicosanoid metabolites in anti-diuretic hormone signaling in Rhodnius prolixus
Paluzzi JP, Young P, Defferrari MS, Orchard I, Carlini CR, O'Donnell MJ
2012, Peptides, 34, 127-34, 22079222
Cloning of the cDNA, localization, and physiological effects of FGLamide-related allatostatins in the blood-gorging bug, Rhodnius prolixus
Zandawala M, Lytvyn Y, Taiakina D, Orchard I
2012, Insect biochemistry and molecular biology, 42, 10-21, 22061445
The Proctolin Gene and Biological Effects of Proctolin in the Blood-Feeding Bug, Rhodnius prolixus
Orchard I, Lee do H, da Silva R, Lange AB
2011, Frontiers in endocrinology, 2, 59, 22654816
Identification of the elusive peptidergic diuretic hormone in the blood-feeding bug Rhodnius prolixus: a CRF-related peptide
Te Brugge V, Paluzzi JP, Schooley DA, Orchard I
2011, The Journal of experimental biology, 214, 371-81, 21228196
2010
Identification of kinin-related peptides in the disease vector, Rhodnius prolixus
Te Brugge V, Paluzzi JP, Neupert S, Nachman RJ, Orchard I
2011, Peptides, 32, 469-74, 20934474
Neuropeptide action in insects and crustaceans
Mykles DL, Adams ME, Gäde G, Lange AB, Marco HG, Orchard I
2010, Physiological and biochemical zoology : PBZ, 83, 836-46, 20550437
Isolation and characterization of the cDNA encoding DH(31) in the kissing bug, Rhodnius prolixus
Zandawala M, Paluzzi JP, Orchard I
2011, Molecular and cellular endocrinology, 331, 79-88, 20797422
Effects of the mycotoxin destruxin A on Locusta migratoria visceral muscles
Ruiz-Sanchez E, Lange AB, Orchard I
2010, Toxicon : official journal of the International Society on Toxinology, 56, 1043-51, 20670642
Isolation, expression analysis, and functional characterization of the first antidiuretic hormone receptor in insects
Paluzzi JP, Park Y, Nachman RJ, Orchard I
2010, Proceedings of the National Academy of Sciences of the United States of America, 107, 10290-5, 20479227
Effects of the cyclopeptide mycotoxin destruxin A on the Malpighian tubules of Rhodnius prolixus (Stål)
Ruiz-Sanchez E, Orchard I, Lange AB
2010, Toxicon : official journal of the International Society on Toxinology, 55, 1162-70, 20060849
2009
The antidiuretic neurohormone RhoprCAPA-2 downregulates fluid transport across the anterior midgut in the blood-feeding insect Rhodnius prolixus
Ianowski JP, Paluzzi JP, Te Brugge VA, Orchard I
2010, American journal of physiology. Regulatory, integrative and comparative physiology, 298, R548-57, 20007522
A second gene encodes the anti-diuretic hormone in the insect, Rhodnius prolixus
Paluzzi JP, Orchard I
2010, Molecular and cellular endocrinology, 317, 53-63, 19931590
Neurohormones implicated in the control of Malpighian tubule secretion in plant sucking heteropterans: The stink bugs Acrosternum hilare and Nezara viridula
Coast GM, TeBrugge VA, Nachman RJ, Lopez J, Aldrich JR, Lange A, Orchard I
2010, Peptides, 31, 468-73, 19772880
Peptides and serotonin control feeding-related events in Rhodnius prolixus
Orchard I
2009, Frontiers in bioscience (Elite edition), 1, 250-62, 19482642
Biological activity of diuretic factors on the anterior midgut of the blood-feeding bug, Rhodnius prolixus
Te Brugge V, Ianowski JP, Orchard I
2009, General and comparative endocrinology, 162, 105-12, 19408362
Diuretic and antidiuretic hormones in the blood-gorging bug Rhodnius prolixus
Orchard I, Paluzzi JP
2009, Annals of the New York Academy of Sciences, 1163, 501-3, 19456399
Invitro effect of Canavalia ensiformis urease and the derived peptide Jaburetox-2Ec on Rhodnius prolixus Malpighian tubules
Stanisçuaski F, Te Brugge V, Carlini CR, Orchard I
2009, Journal of insect physiology, 55, 255-63, 19121321
Physiological activity of neuropeptide f on the hindgut of the blood-feeding hemipteran, Rhodnius prolixus
Gonzalez R, Orchard I
2009, Journal of insect science (Online), 9, 1-14, 20050776
2008
Isolation, cloning, and expression mapping of a gene encoding an antidiuretic hormone and other CAPA-related peptides in the disease vector, Rhodnius prolixus
Paluzzi JP, Russell WK, Nachman RJ, Orchard I
2008, Endocrinology, 149, 4638-46, 18511504
Amino acid sequence and biological activity of a calcitonin-like diuretic hormone (DH31) from Rhodnius prolixus
Brugge VA, Schooley DA, Orchard I
2008, The Journal of experimental biology, 211, 382-90, 18203994
Differential actions of diuretic factors on the Malpighian tubules of Rhodnius prolixus
Donini A, O'Donnell MJ, Orchard I
2008, The Journal of experimental biology, 211, 42-8, 18083731
2007
Characterization of neuropeptide F-like immunoreactivity in the blood-feeding hemipteran, Rhodnius prolixus
Gonzalez R, Orchard I
2008, Peptides, 29, 545-58, 18201798
Insect neuroendocrinology in the post-genomic era
Nässel D, Orchard I
2007, General and comparative endocrinology, 153, 57-8, 17666203
Isolation and sequencing of two FMRFamide-related peptides from the gut of Locusta migratoria L
Hill SR, Orchard I
2007, Peptides, 28, 1490-7, 17707763
2006
Distribution, activity and evidence for the release of an anti-diuretic peptide in the kissing bug Rhodnius prolixus
Paluzzi JP, Orchard I
2006, The Journal of experimental biology, 209, 907-15, 16481579
2005
Serotonin: a coordinator of feeding-related physiological events in the blood-gorging bug, Rhodnius prolixus
Orchard I
2006, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 144, 316-24, 16377224
The distribution and activity of tachykinin-related peptides in the blood-feeding bug, Rhodnius prolixus
Kwok R, Chung D, Brugge VT, Orchard I
2005, Peptides, 26, 43-51, 15626503
In vitro analysis of the digestive enzymes amylase and alpha-glucosidase in the midguts of Locusta migratoria L. in response to the myosuppressin, SchistoFLRFamide
Hill SR, Orchard I
2005, Journal of insect physiology, 51, 1-9, 15686640
2004
The influence of diet and feeding state on FMRFamide-related peptides in the gut of Locusta migratoria L
Hill SR, Orchard I
2004, Peptides, 25, 105-14, 15003362
The effects of dopamine agonists and antagonists on the secretory responses in the salivary glands of the locust (Locusta migratoria)
Keating C, Orchard I
2004, Journal of insect physiology, 50, 17-23, 15037089
2003
FMRFamide-related peptides in the gut of Locusta migratoria L.: a comprehensive map and developmental profile
Hill SR, Orchard I
2003, Peptides, 24, 1511-24, 14706530
The distribution and effects of Dippu-allatostatin-like peptides in the blood-feeding bug, Rhodnius prolixus
Sarkar NR, Tobe SS, Orchard I
2003, Peptides, 24, 1553-62, 14706534
2002
Central effects of the peptides, SchistoFLRFamide and proctolin, on locust oviduct contraction
Kwok R, Orchard I
2002, Peptides, 23, 1925-32, 12431730
Characterization of a putative SchistoFLRFamide receptor in the CNS of Locusta migratoria
Kwok R, Orchard I
2002, Peptides, 23, 765-72, 11897396