John Peever

faculty_img Academic Title:  Professor

Campus: St. George

CSB Appointment: Full

Primary Undergraduate Department:
Cell & Systems Biology

Graduate Programs:
Cell & Systems Biology

Titles and Honors:
CIHR Research Fellow

Academic or Administrative Appointments:
Director Centre for Biology Timing and Cognition
VP Research Canadian Sleep Society

Education:
Ph.D. University of Toronto 2001
Mailing Address
Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
Canada
Contact Information
Office phone: 416-946-5564
Office: RW 315B
Lab: RW307/314/315
Lab phone: 946-7236/7235/7240
Email: john.peever@utoronto.ca
URL: http://www.peeverlab.com/
Research Areas
Neurobiology
Physiology
Systems Biology
Research

Our research aims to understand how the brain generates and regulates behavioral arousal states. My research team uses optogenetic and pharmacogenetic methods to dissect the brain circuitry controlling behavioral arousal state, particularly sleep. This work will not only identify the pathways that trigger sleep and wakefulness, it will also be invaluable in understanding how breakdown in brain circuits contributes to sleep disorders such as narcolepsy and REM sleep behavior disorder.

Publications

2019

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Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy..Szabo ST, Thorpy MJ, Mayer G, Peever JH, Kilduff TS. Sleep Med Rev 2019 02; 43():23-36
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2018

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Brainstem Nuclei Associated with Mediating Apnea-Induced Respiratory Motor Plasticity..Lui S, Torontali Z, Tadjalli A, Peever J. Sci Rep 2018 Aug 23; 8(1):12709
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Neuroscience: A \'Skin Warming\' Circuit that Promotes Sleep and Body Cooling..Peever J. Curr. Biol. 2018 Jul 23; 28(14):R800-R802
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2017

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The Biology of REM Sleep..Peever J, Fuller PM. Curr. Biol. 2017 Nov 20; 27(22):R1237-R1248
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Brain Circuitry Controlling Sleep and Wakefulness..Horner RL, Peever JH. Continuum (Minneap Minn) 2017 08; 23(4, Sleep Neurology):955-972
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Degeneration of rapid eye movement sleep circuitry underlies rapid eye movement sleep behavior disorder..McKenna D, Peever J. Mov. Disord. 2017 05; 32(5):636-644
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Circuit mechanisms of sleepiness and cataplexy in narcolepsy..Pintwala S, Peever J. Curr. Opin. Neurobiol. 2017 06; 44():50-58
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GABA Cells in the Central Nucleus of the Amygdala Promote Cataplexy..Snow MB, Fraigne JJ, Thibault-Messier G, Chuen VL, Thomasian A, Horner RL, Peever J. J. Neurosci. 2017 04 12; 37(15):4007-4022
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2016

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Monoamine Release during Unihemispheric Sleep and Unihemispheric Waking in the Fur Seal.Lyamin OI, Lapierre JL, Kosenko PO, Kodama T, Bhagwandin A, Korneva SM, Peever JH, Mukhametov LM, Siegel JM. Sleep 2016;39(3):625-36
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2014

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Cataplexy-clinical aspects, pathophysiology and management strategy.Dauvilliers Y, Siegel JM, Lopez R, Torontali ZA, Peever JH. Nat Rev Neurol 2014 Jul;10(7):386-95
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Noradrenergic modulation of masseter muscle activity during natural rapid eye movement sleep requires glutamatergic signalling at the trigeminal motor nucleus.Schwarz PB, Mir S, Peever JH. J. Physiol. (Lond.) 2014 May;
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Cholinergic involvement in control of REM sleep paralysis.Torontali ZA, Grace KP, Horner RL, Peever JH. J. Physiol. (Lond.) 2014 Apr;592(Pt 7):1425-6
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2013

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Melanin-concentrating hormone neurons promote and stabilize sleep.Fraigne JJ, Peever JH. Sleep 2013 Dec;36(12):1767-8
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Brain biology: jerked around by sleep.Fraigne JJ, Peever JH. Curr. Biol. 2013 Nov;23(21):R954-6
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A noradrenergic mechanism functions to couple motor behavior with arousal state.Burgess CR, Peever JH. Curr. Biol. 2013 Sep;23(18):1719-25
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Amygdala lesions reduce cataplexy in orexin knock-out mice.Burgess CR, Oishi Y, Mochizuki T, Peever JH, Scammell TE. J. Neurosci. 2013 Jun;33(23):9734-42
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Symmetrical serotonin release during asymmetrical slow-wave sleep: implications for the neurochemistry of sleep-waking states.Lapierre JL, Kosenko PO, Kodama T, Peever JH, Mukhametov LM, Lyamin OI, Siegel JM. J. Neurosci. 2013 Feb;33(6):2555-61
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2012

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Identification of the transmitter and receptor mechanisms responsible for REM sleep paralysis.Brooks PL, Peever JH. J. Neurosci. 2012 Jul;32(29):9785-95
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2011

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Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump.Kirshenbaum GS, Clapcote SJ, Duffy S, Burgess CR, Petersen J, Jarowek KJ, Yücel YH, Cortez MA, Snead OC, Vilsen B, Peever JH, Ralph MR, Roder JC. Proc. Natl. Acad. Sci. U.S.A. 2011 Nov;108(44):18144-9
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Dopamine triggers skeletal muscle tone by activating D1-like receptors on somatic motoneurons.Schwarz PB, Peever JH. J. Neurophysiol. 2011 Sep;106(3):1299-309
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Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice.Brooks PL, Peever JH. J. Neurosci. 2011 May;31(19):7111-21
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2010

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Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy.Burgess CR, Tse G, Gillis L, Peever JH. Sleep 2010 Oct;33(10):1295-304
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Noradrenergic control of trigeminal motoneurons in sleep: relevance to sleep apnea.Schwarz PB, Peever JH. Adv. Exp. Med. Biol. 2010;669:281-4
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GABAergic and glycinergic control of upper airway motoneurons in rapid eye movement sleep.Brooks PL, Peever JH. Adv. Exp. Med. Biol. 2010;669:259-62
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2008

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Unraveling the mechanisms of REM sleep atonia.Brooks PL, Peever JH. Sleep 2008 Nov;31(11):1492-7
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Noradrenaline triggers muscle tone by amplifying glutamate-driven excitation of somatic motoneurones in anaesthetized rats.Schwarz PB, Yee N, Mir S, Peever JH. J. Physiol. (Lond.) 2008 Dec;586(Pt 23):5787-802
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Glycinergic and GABA(A)-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia.Brooks PL, Peever JH. J. Neurosci. 2008 Apr;28(14):3535-45
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Biochemical control of airway motor neurons during rapid eye movement sleep.Brooks PL, Peever JH. Adv. Exp. Med. Biol. 2008;605:437-41
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2003

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Connections between respiratory neurones in the neonatal rat transverse medullary slice studied with cross-correlation.Li YM, Shen L, Peever JH, Duffin J. J. Physiol. (Lond.) 2003 May;549(Pt 1):327-32
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Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonism.Peever JH, Lai YY, Siegel JM. J. Neurophysiol. 2003 May;89(5):2591-600
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2002

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Acetazolamide and respiratory chemosensitivity to CO(2) in the neonatal rat transverse medullary slice.Necakov A, Peever JH, Shen L, Duffin J. Respir Physiol Neurobiol 2002 Sep;132(3):279-87
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Bilateral coordination of inspiratory neurones in the rat.Shen L, Peever JH, Duffin J. Pflugers Arch. 2002 Mar;443(5-6):829-35
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