Leslie Buck

faculty_img Academic Title: Professor

Campus: St. George

CSB Appointment: Full

Primary Undergraduate Department:
Cell & Systems Biology

Graduate Programs:
Cell & Systems Biology
Collaborative Program in Neuroscience

Titles and Honors:

 


Academic or Administrative Appointments:
Associate Chair for Graduate Studies – July 1, 2009 to July 1, 2015

Education:
Ph.D. University of British Columbia 1993
B.Sc.. Brock University 1986

Mailing Address
Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
Canada
 
Contact Information
Office phone: 416-978-3506 
Office: RW 329B 
Lab: RW 328 / 329 
Lab phone: 416-946-7238 
Email: les.buck@utoronto.ca 
URL:
Research Areas
Animal Biology
Cell Biology
Neurobiology
Physiology
Research

 

Publications

2019

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Mitochondrial matrix pH acidifies during anoxia and is maintained by the FF-ATPase in anoxia-tolerant painted turtle cortical neurons..Hawrysh PJ, Buck LT. FEBS Open Bio 2019 Apr; 9(4):571-581
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2018

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Taurine activates glycine and GABA receptor currents in anoxia-tolerant painted turtle pyramidal neurons..Miles AR, Hawrysh PJ, Hossein-Javaheri N, Buck LT. J. Exp. Biol. 2018 Nov 05; 221(Pt 21):
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2017

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Stellate and pyramidal neurons in goldfish telencephalon respond differently to anoxia and GABA receptor inhibition..Hossein-Javaheri N, Wilkie MP, Lado WE, Buck LT. J. Exp. Biol. 2017 02 15; 220(Pt 4):695-704
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Assessment of anoxia tolerance and photoperiod dependence of GABAergic polarity in the pond snail Lymnaea stagnalis..Buck LT, Bond HC, Malik A. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 2017 01; 203():193-200
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2016

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Phosphorylation of the mitochondrial ATP-sensitive potassium channel occurs independently of PKCε in turtle brain..Hawrysh PJ, Miles AR, Buck LT. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2016 Oct; 200():44-53
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Sensing and surviving hypoxia in vertebrates..Jonz MG, Buck LT, Perry SF, Schwerte T, Zaccone G. Ann. N. Y. Acad. Sci. 2016 Feb; 1365(1):43-58
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2015

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Transcriptomic Responses of the Heart and Brain to Anoxia in the Western Painted Turtle..Keenan SW, Hill CA, Kandoth C, Buck LT, Warren DE. PLoS ONE 2015; 10(7):e0131669
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Decreases in mitochondrial reactive oxygen species initiate GABAA receptor-mediated electrical suppression in anoxia-tolerant turtle neurons.Hogg DW, Pamenter ME, Dukoff DJ, Buck LT. J. Physiol. (Lond.) 2015 Mar;
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Proteomic changes in the brain of the western painted turtle (Chrysemys picta bellii) during exposure to anoxia.Smith RW, Cash P, Hogg DW, Buck LT. Proteomics 2015 Jan;
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2014

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Environmental remodelling of GABAergic and glutamatergic neurotransmission: rise of the anoxia-tolerant turtle brain.Hogg DW, Hawrysh PJ, Buck LT. J. Therm. Biol. 2014 Aug;44:85-92
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Scavenging ROS dramatically increases NMDA receptor whole cell currents in painted turtle cortical neurons.Dukoff DJ, Hogg DW, Hawrsyh PJ, Buck LT. J. Exp. Biol. 2014 Jul;
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2013

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Anoxia-mediated calcium release through the mitochondrial permeability transition pore silences NMDA receptor currents in turtle neurons.Hawrysh PJ, Buck LT. J. Exp. Biol. 2013 Dec;216(Pt 23):4375-87
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The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage.Bradley Shaffer H, Minx P, Warren DE, Shedlock AM, Thomson RC, Valenzuela N, Abramyan J, Amemiya CT, Badenhorst D, Biggar KK, Borchert GM, Botka CW, Bowden RM, Braun EL, Bronikowski AM, Bruneau BG, Buck LT, Capel B, Castoe TA, Czerwinski M, Delehaunty KD, Edwards SV, Fronick CC, Fujita MK, Fulton L, Graves TA, Green RE, Haerty W, Hariharan R, Hernandez O, Hillier LW, Holloway AK, Janes D, Janzen FJ, Kandoth C, Kong L, de Koning AJ, Li Y, Literman R, McGaugh SE, Mork L, O'Laughlin M, Paitz RT, Pollock DD, Ponting CP, Radhakrishnan S, Raney BJ, Richman JM, St John J, Schwartz T, Sethuraman A, Spinks PQ, Storey KB, Thane N, Vinar T, Zimmerman LM, Warren WC, Mardis ER, Wilson RK. Genome Biol. 2013;14(3):R28
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Oxygen-sensitive reduction in Ca²⁺-activated K⁺ channel open probability in turtle cerebrocortex.Rodgers-Garlick CI, Hogg DW, Buck LT. Neuroscience 2013 May;237:243-54
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2012

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Oxygen sensitive synaptic neurotransmission in anoxia-tolerant turtle cerebrocortex.Buck LT, Hogg DW, Rodgers-Garlick C, Pamenter ME. Adv. Exp. Med. Biol. 2012;758:71-9
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Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra.Pamenter ME, Hogg DW, Gu XQ, Buck LT, Haddad GG. J. Cereb. Blood Flow Metab. 2012 Nov;32(11):2033-43
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2011

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The relationship between NMDA receptor function and the high ammonia tolerance of anoxia-tolerant goldfish.Wilkie MP, Pamenter ME, Duquette S, Dhiyebi H, Sangha N, Skelton G, Smith MD, Buck LT. J. Exp. Biol. 2011 Dec;214(Pt 24):4107-20
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Endogenous GABA(A) and GABA(B) receptor-mediated electrical suppression is critical to neuronal anoxia tolerance.Pamenter ME, Hogg DW, Ormond J, Shin DS, Woodin MA, Buck LT. Proc. Natl. Acad. Sci. U.S.A. 2011 Jul;108(27):11274-9
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2010

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Regulation of AMPA receptor currents by mitochondrial ATP-sensitive K+ channels in anoxic turtle neurons.Zivkovic G, Buck LT. J. Neurophysiol. 2010 Oct;104(4):1913-22
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Adenosinergic modulation of neuronal activity in the pond snail Lymnaea stagnalis.Malik A, Buck LT. J. Exp. Biol. 2010 Apr;213(Pt 7):1126-32
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2009

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Matching cellular metabolic supply and demand in energy-stressed animals.Staples JF, Buck LT. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 2009 Jun;153(2):95-105
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2008

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delta-Opioid receptor antagonism induces NMDA receptor-dependent excitotoxicity in anoxic turtle cortex.Pamenter ME, Buck LT. J. Exp. Biol. 2008 Nov;211(Pt 21):3512-7
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Evidence of anoxia-induced channel arrest in the brain of the goldfish (Carassius auratus).Wilkie MP, Pamenter ME, Alkabie S, Carapic D, Shin DS, Buck LT. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2008 Nov;148(4):355-62
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Neuronal membrane potential is mildly depolarized in the anoxic turtle cortex.Pamenter ME, Buck LT. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 2008 Aug;150(4):410-4
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Endogenous reductions in N-methyl-d-aspartate receptor activity inhibit nitric oxide production in the anoxic freshwater turtle cortex.Pamenter ME, Hogg DW, Buck LT. FEBS Lett. 2008 May;582(12):1738-42
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Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons.Pamenter ME, Shin DS, Buck LT. Brain Res. 2008 Jun;1213:27-34
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Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle.Pamenter ME, Shin DS, Cooray M, Buck LT. J. Physiol. (Lond.) 2008 Feb;586(4):1043-58
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AMPA receptors undergo channel arrest in the anoxic turtle cortex.Pamenter ME, Shin DS, Buck LT. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008 Feb;294(2):R606-13
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2007

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Anoxia-induced changes in reactive oxygen species and cyclic nucleotides in the painted turtle.Pamenter ME, Richards MD, Buck LT. J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. 2007 May;177(4):473-81
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Piscine insights into comparisons of anoxia tolerance, ammonia toxicity, stroke and hepatic encephalopathy.Walsh PJ, Veauvy CM, McDonald MD, Pamenter ME, Buck LT, Wilkie MP. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 2007 Jun;147(2):332-43
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Hypoxia tolerance in reptiles, amphibians, and fishes: life with variable oxygen availability.Bickler PE, Buck LT. Annu. Rev. Physiol. 2007;69:145-70
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2006

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Excitatory actions of GABA mediate severe-hypoxia-induced depression of neuronal activity in the pond snail (Lymnaea stagnalis).Cheung U, Moghaddasi M, Hall HL, Smith JJ, Buck LT, Woodin MA. J. Exp. Biol. 2006 Nov;209(Pt 22):4429-35
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2005

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Calcium and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex.Shin DS, Wilkie MP, Pamenter ME, Buck LT. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 2005 Sep;142(1):50-7
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2004

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Adenosine as a signal for ion channel arrest in anoxia-tolerant organisms.Buck LT. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2004 Nov;139(3):401-14
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Bacterial infection and tissue-specific Hsp72, -73 and -90 expression in western painted turtles.Ramaglia V, Harapa GM, White N, Buck LT. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2004 Jun;138(2):139-48
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Time-dependent expression of heat shock proteins 70 and 90 in tissues of the anoxic western painted turtle.Ramaglia V, Buck LT. J. Exp. Biol. 2004 Oct;207(Pt 21):3775-84
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2003

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Effect of anoxia and pharmacological anoxia on whole-cell NMDA receptor currents in cortical neurons from the western painted turtle.Shin DS, Buck LT. Physiol. Biochem. Zool. 2003 Jan-Feb;76(1):41-51
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Gap junctions do not underlie changes in whole-cell conductance in anoxic turtle brain.Shin DS, Ghai H, Cain SW, Buck LT. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 2003 Jan;134(1):181-94
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Tissue-specific expression of inducible and constitutive Hsp70 isoforms in the western painted turtle.Scott MA, Locke M, Buck LT. J. Exp. Biol. 2003 Jan;206(Pt 2):303-11
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2002

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Molecular adaptations for survival during anoxia: lessons from lower vertebrates.Bickler PE, Donohoe PH, Buck LT. Neuroscientist 2002 Jun;8(3):234-42
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