Mauricio Terebiznik

faculty_img Academic Title: Associate Professor

Campus: UTSC

CSB Appointment: Full

Primary Undergraduate Department:
Biological Sciences, UTSC

Graduate Programs:
Cell & Systems Biology

Physical & Environmental Sciences

Titles and Honors:
Academic or Administrative Appointments:
Ph.D. University of Buenos Aires


Mailing Address
Department of Cell & Systems Biology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4


Contact Information
Office phone: 416-287-7655
Office: SW 535A
Lab: SW 316A
Lab phone: 416-208-2692


Research Areas
Cell Biology
Structural Biology



My laboratory specializes in cellular microbiology and cell biology. We investigate different unexplored aspects of the interplay of macrophages, and epithelial cells with the intracellular pathogen Legionella pneumophila (Legionella). Legionella is pleomorphic and its different morphotypes carry different levels of virulence. The filamentous Legionella (FL) has been reported in patient samples since the first descriptions of this bacteria. However, its virulence has never been investigated. In my laboratory we study the cellular pathways subverted by FL to enter epithelial cells and how bacterial filamentous morphology contribute in the disruption of phagocytosis in macrophages. We are also interested in Legionella pneumophila’s mechanism for biofilm development and attachment to abiotic surfaces and cells. We are also interested in the study of the phagocytosis of asbestos. Fibers of asbestos deposit on lung airways and ultimately accumulate in the parietal pleura. Longer fibers cannot be cleared by macrophages and persist to induce inflammatory responses, leading to fibrosis and mesothelioma. The persistence of these fibers has been attributed to the inability of macrophages to engulf fibers, causing phagocytosis to stall at the phagocytic cup stage. My lab, is studying the phagocytosis of asbestos to cha




The Legionella pneumophila collagen-like protein mediates sedimentation, autoaggregation, and pathogen-phagocyte interactions.Abdel-Nour M, Duncan C, Prashar A, Rao C, Ginevra C, Jarraud S, Low DE, Ensminger AW, Terebiznik MR, Guyard C. Appl. Environ. Microbiol. 2014 Feb;80(4):1441-54


Filamentous morphology of bacteria delays the timing of phagosome morphogenesis in macrophages.Prashar A, Bhatia S, Gigliozzi D, Martin T, Duncan C, Guyard C, Terebiznik MR. J. Cell Biol. 2013 Dec;203(6):1081-97


Chlamydia trachomatis vacuole maturation in infected macrophages.Sun HS, Eng EW, Jeganathan S, Sin AT, Patel PC, Gracey E, Inman RD, Terebiznik MR, Harrison RE. J. Leukoc. Biol. 2012 Oct;92(4):815-27
Mechanism of invasion of lung epithelial cells by filamentous Legionella pneumophila.Prashar A, Bhatia S, Tabatabaeiyazdi Z, Duncan C, Garduño RA, Tang P, Low DE, Guyard C, Terebiznik MR. Cell. Microbiol. 2012 Oct;14(10):1632-55
Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans.Raju D, Hussey S, Ang M, Terebiznik MR, Sibony M, Galindo-Mata E, Gupta V, Blanke SR, Delgado A, Romero-Gallo J, Ramjeet MS, Mascarenhas H, Peek RM, Correa P, Streutker C, Hold G, Kunstmann E, Yoshimori T, Silverberg MS, Girardin SE, Philpott DJ, El Omar E, Jones NL. Gastroenterology 2012 May;142(5):1160-71


Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells.Terebiznik MR, Raju D, Vázquez CL, Torbricki K, Kulkarni R, Blanke SR, Yoshimori T, Colombo MI, Jones NL. Autophagy 2009 Apr;5(3):370-9


SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34.Mallo GV, Espina M, Smith AC, Terebiznik MR, Alemán A, Finlay BB, Rameh LE, Grinstein S, Brumell JH. J. Cell Biol. 2008 Aug;182(4):741-52
Autophagy: healthy eating and self-digestion for gastroenterologists.Hussey S, Terebiznik MR, Jones NL. J. Pediatr. Gastroenterol. Nutr. 2008 May;46(5):496-506


Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2.Binker MG, Cosen-Binker LI, Terebiznik MR, Mallo GV, McCaw SE, Eskelinen EL, Willenborg M, Brumell JH, Saftig P, Grinstein S, Gray-Owen SD. Cell. Microbiol. 2007 Sep;9(9):2153-66
Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L, Grinstein S. J. Gen. Physiol. 2007 Apr;129(4):267-83


Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella.Terebiznik MR, Vieira OV, Marcus SL, Slade A, Yip CM, Trimble WS, Meyer T, Finlay BB, Grinstein S. Nat. Cell Biol. 2002 Oct;4(10):766-73