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MSc Exit Seminar – Delara Dadsepah -Tuesday, May 29, 2018
May 29, 2018 @ 2:10 pm - 3:00 pm
MSc Exit Seminar
Tuesday, May 29, 2018 at 2:10pm CCT -3000, University of Toronto at Mississauga
Delara Dadsepah (Levine Lab)
Anatomical and Behavioural Characterization of Dpr-Interacting Protein Beta in Drosophila melanogaster
The mammalian limbic system has many important biological functions. During development, the limbic-system associated membrane protein (LSAMP) plays a crucial role by ensuring proper neuronal connectivity within the system. Similarly, the LSAMP homologue in the Drosophila, the Dpr-interacting protein beta (DIP-β), is believed to assist in neuronal formation during the development of the fly central nervous system. Other data suggests that DIP-β even regulates social interactions. Researchers have only more recently begun investigating DIP-β however, and DIP-β remains to be extensively studied. Thus, the aim of this project was to fully characterize DIP-β expression in the brain and the behaviour of DIP-β mutants, to obtain a better understanding of DIP-β function. DIP-β’s predominant expression in the optic lobes and regions in the central brain, along with changes in behavioural rhythmicity observed in DIP-β mutants, suggests DIP-β may be associated with clock mechanisms.