Adam Mott

faculty_img Academic Title: Assistant Professor

Campus: UTSC

CSB Appointment: Full

Primary Undergraduate Department: Department of Biological Sciences

Graduate Programs:
Cell and Systems Biology

Academic or Administrative Appointments:

Ph.D. Harvard University, 2008
B.Sc. University of British Columbia, 2001


Mailing Address
Department of Cell & Systems Biology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4


Contact Information
Office phone: 416-287-7427
Lab phone:
Lab:SY-270 Lab 1
URL: n/a


Research Areas
Plant Biology
Systems Biology
Molecular Biology
Cell Biology
Evolutionary Biology



All living things must be able to sense and respond to their environment in order to survive and thrive. Plants are unable to move in order to seek better environmental conditions or to avoid pathogens and pests. Instead, they have a large number of cell surface receptors that collect information about environmental conditions and pathogen presence. The information gathered by these receptors is integrated by the plant cell and used to guide energy expenditures that optimize growth and immune activation. Our lab studies these receptors so that we can understand what signals each one perceives, how the receptors interact to combine the information that each one gathers, and how they evolved to perform these functions. To do this we use a variety of techniques in the wet lab combined with computational analyses of large data-sets. We focus on the model organism Arabidopsis thaliana, and then take our discoveries from that system and translate them into improved crop varieties to support local agriculture.







An extracellular network of Arabidopsis leucine-rich repeat receptor kinases. Smakowska-Luzan E, Mott GA, Parys K, Stegmann M, Howton TC, Layeghifard M, Neuhold J, Lehner A, Kong J, Grünwald K, Weinberger N, Satbhai SB, Mayer D, Busch W, Madalinski M, Stolt-Bergner P, Provart NJ, Mukhtar MS, Zipfel C, Desveaux D, Guttman DS, Belkhadir Y. Nature. 2018 Jan 18;553(7688):342-346. doi: 10.1038/nature25184. Epub 2018 Jan 10.
A High-Sensitivity, Microtiter-Based Plate Assay for Plant Pattern-Triggered Immunity. Mott GA, Desveaux D, Guttman DS. Mol Plant Microbe Interact. 2018 May;31(5):499-504. doi: 10.1094/MPMI-11-17-0279-TA. Epub 2018 Feb 28.



An Alternative Strategy for Trypanosome Survival in the Mammalian Bloodstream Revealed through Genome and Transcriptome Analysis of the Ubiquitous Bovine Parasite Trypanosoma (Megatrypanum) theileri. Kelly S, Ivens A, Mott GA, O’Neill E, Emms D, Macleod O, Voorheis P, Tyler K, Clark M, Matthews J, Matthews K, Carrington M. Genome Biol Evol. 2017 Aug 1;9(8):2093-2109. doi: 10.1093/gbe/evx152.pubmed
The study of pattern-triggered immunity in Arabidopsis. G. Adam Mott, David S. Guttman & Darrell Desveaux. Canadian Journal of Plant Pathology, Pages 275-281 | Accepted 12 Jul 2017, Accepted author version posted online: 19 Jul 2017, Published online: 09 Aug 2017DOI



Genomic screens identify a new phytobacterial microbe-associated molecular pattern and the cognate Arabidopsis receptor-like kinase that mediates its immune elicitation. Mott GA, Thakur S, Smakowska E, Wang PW, Belkhadir Y, Desveaux D, Guttman DS. Genome Biol. 2016 May 9;17:98. doi: 10.1186/s13059-016-0955-7.



Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis. Lewis JD, Wilton M, Mott GA, Lu W, Hassan JA, Guttman DS, Desveaux D. PLoS One. 2014 Dec 29;9(12):e116152. doi: 10.1371/journal.pone.0116152. eCollection 2014.
Peptides and small molecules of the plant-pathogen apoplastic arena. Mott GA, Middleton MA, Desveaux D, Guttman DS. Front Plant Sci. 2014 Nov 28;5:677. doi: 10.3389/fpls.2014.00677. eCollection 2014.
The Pseudomonas syringae type III effector HopF2 suppresses Arabidopsis stomatal immunity. Hurley B, Lee D, Mott A, Wilton M, Liu J, Liu YC, Angers S, Coaker G, Guttman DS, Desveaux D. PLoS One. 2014 Dec 11;9(12):e114921. doi: 10.1371/journal.pone.0114921. eCollection 2014.



Targeting cattle-borne zoonoses and cattle pathogens using a novel trypanosomatid-based delivery system. Mott GA, Wilson R, Fernando A, Robinson A, MacGregor P, Kennedy D, Schaap D, Matthews JB, Matthews KR. PLoS Pathog. 2011 Oct;7(10):e1002340. doi: 10.1371/journal.ppat.1002340. Epub 2011 Oct 27.
A soluble factor from Trypanosoma cruzi inhibits transforming growth factor-ß-induced MAP kinase activation and gene expression in dermal fibroblasts. Mott GA, Costales JA, Burleigh BA. PLoS One. 2011;6(9):e23482. doi: 10.1371/journal.pone.0023482. Epub 2011 Sep 8.



Modulation of host cell mechanics by Trypanosoma cruzi. Mott A, Lenormand G, Costales J, Fredberg JJ, Burleigh BA. J Cell Physiol. 2009 Feb;218(2):315-22. doi: 10.1002/jcp.21606.



The role of host cell lysosomes in Trypanosoma cruzi invasion. Mott GA, Burleigh BA. Subcell Biochem. 2008;47:165-73.