Adam Mott

faculty_img Academic Title: Assistant Professor

Campus: UTSC

CSB Appointment: Full

Primary Undergraduate Department: Department of Biological Sciences

Graduate Programs:
Cell and Systems Biology

Academic or Administrative Appointments:

Ph.D. Harvard University, 2008
B.Sc. University of British Columbia, 2001

Mailing Address
Department of Cell & Systems Biology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4
Contact Information
Office phone: 416-287-7427
Lab phone:
Lab:SY-270 Lab 1
URL: n/a
Research Areas
Plant Biology
Systems Biology
Molecular Biology
Cell Biology
Evolutionary Biology

All living things must be able to sense and respond to their environment in order to survive and thrive. Plants are unable to move in order to seek better environmental conditions or to avoid pathogens and pests. Instead, they have a large number of cell surface receptors that collect information about environmental conditions and pathogen presence. The information gathered by these receptors is integrated by the plant cell and used to guide energy expenditures that optimize growth and immune activation. Our lab studies these receptors so that we can understand what signals each one perceives, how the receptors interact to combine the information that each one gathers, and how they evolved to perform these functions. To do this we use a variety of techniques in the wet lab combined with computational analyses of large data-sets. We focus on the model organism Arabidopsis thaliana, and then take our discoveries from that system and translate them into improved crop varieties to support local agriculture.


An extracellular network of Arabidopsis leucine-rich repeat receptor kinases..Smakowska-Luzan E, Mott GA, Parys K, Stegmann M, Howton TC, Layeghifard M, Neuhold J, Lehner A, Kong J, Grünwald K, Weinberger N, Satbhai SB, Mayer D, Busch W, Madalinski M, Stolt-Bergner P, Provart NJ, Mukhtar MS, Zipfel C, Desveaux D, Guttman DS, Belkhadir Y. Nature 2018 01 18; 553(7688):342-346
A High-Sensitivity, Microtiter-Based Plate Assay for Plant Pattern-Triggered Immunity..Mott GA, Desveaux D, Guttman DS. Mol. Plant Microbe Interact. 2018 05; 31(5):499-504


An Alternative Strategy for Trypanosome Survival in the Mammalian Bloodstream Revealed through Genome and Transcriptome Analysis of the Ubiquitous Bovine Parasite Trypanosoma (Megatrypanum) theileri..Kelly S, Ivens A, Mott GA, O\'Neill E, Emms D, Macleod O, Voorheis P, Tyler K, Clark M, Matthews J, Matthews K, Carrington M. Genome Biol Evol 2017 08 01; 9(8):2093-2109
The study of pattern-triggered immunity in Arabidopsis.Mott GA, Guttman DS, Desveaux D. 2017. Canadian Journal of Plant Pathology.


Genomic screens identify a new phytobacterial microbe-associated molecular pattern and the cognate Arabidopsis receptor-like kinase that mediates its immune elicitation..Mott GA, Thakur S, Smakowska E, Wang PW, Belkhadir Y, Desveaux D, Guttman DS. Genome Biol. 2016 May 09; 17():98


Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis..Lewis JD, Wilton M, Mott GA, Lu W, Hassan JA, Guttman DS, Desveaux D. PLoS ONE 2014; 9(12):e116152
Peptides and small molecules of the plant-pathogen apoplastic arena..Mott GA, Middleton MA, Desveaux D, Guttman DS. Front Plant Sci 2014; 5():677
The Pseudomonas syringae type III effector HopF2 suppresses Arabidopsis stomatal immunity..Hurley B, Lee D, Mott A, Wilton M, Liu J, Liu YC, Angers S, Coaker G, Guttman DS, Desveaux D. PLoS ONE 2014; 9(12):e114921


Targeting cattle-borne zoonoses and cattle pathogens using a novel trypanosomatid-based delivery system..Mott GA, Wilson R, Fernando A, Robinson A, MacGregor P, Kennedy D, Schaap D, Matthews JB, Matthews KR. PLoS Pathog. 2011 Oct; 7(10):e1002340
A soluble factor from Trypanosoma cruzi inhibits transforming growth factor-ß-induced MAP kinase activation and gene expression in dermal fibroblasts..Mott GA, Costales JA, Burleigh BA. PLoS ONE 2011; 6(9):e23482


Modulation of host cell mechanics by Trypanosoma cruzi..Mott A, Lenormand G, Costales J, Fredberg JJ, Burleigh BA. J. Cell. Physiol. 2009 Feb; 218(2):315-22


The role of host cell lysosomes in Trypanosoma cruzi invasion..Mott GA, Burleigh BA. Subcell. Biochem. 2008; 47():165-73