Welcome to the Department of Cell & Systems Biology

The molecular biology revolution has given us the unprecedented ability to explore fundamental mechanisms that govern life. Researchers in the Department of Cell & Systems Biology work to understand these mechanisms at all levels of biological organization using a wide array of state-of-the-art molecular, genomic, proteomic, cell biological, imaging, physiological and computational tools and methods.

- - KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control Dhaliwal NK, Abatti LE, Mitchell JA, Genes & Dev 2019;33(1):1-14 [CSB story on this paper] [UofT story on this paper]
  - High Temporal-Resolution Transcriptome Landscape of Early Maize Seed Development Yi F, Gu W, Chen J, Song N, Gao X, Zhang X, Zhou Y, Ma X, Song W, Zhao H, Esteban E, Pasha A, Provart NJ, Lai J, Plant Cell. 2019 May;31(5):974-992.
  - A cargo model of yolk syncytial nuclear migration during zebrafish epiboly. Fei Z, Bae K, Parent SE, Wan H, Goodwin K, Theisen U, Tanentzapf G, Bruce AEE, Development. 2019 Jan 2;146(1). [Video summary of this paper]
  - Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration. Gerber T, Murawala P, Knapp D, Masselink W, Schuez M, Hermann S, Gac-Santel M, Nowoshilow S, Kageyama J, Khattak S, Currie JD, Camp JG, Tanaka EM, Treutlein B, Science. 2018 Oct 26;362(6413).
  - Oxidative Stress Orchestrates Cell Polarity to Promote Embryonic Wound Healing. Hunter MV, Willoughby PM, Bruce AEE, Fernandez-Gonzalez R, Dev Cell. 2018 Nov 5;47(3):377-387.e4.
  - Collision of Expanding Actin Caps with Actomyosin Borders for Cortical Bending and Mitotic Rounding in a Syncytium. Zhang Y, Yu JC, Jiang T, Fernandez-Gonzalez R, Harris TJC. Dev Cell. 2018 Jun 4;45(5):551-564.e4.