Welcome to the Department of Cell & Systems Biology

The molecular biology revolution has given us the unprecedented ability to explore fundamental mechanisms that govern life. Researchers in the Department of Cell & Systems Biology work to understand these mechanisms at all levels of biological organization using a wide array of state-of-the-art molecular, genomic, proteomic, cell biological, imaging, physiological and computational tools and methods.

- - KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control Dhaliwal NK, Abatti LE, Mitchell JA Genes & Dev 2019 (June 20) doi:10.1101/gad.324319.119
  - A cargo model of yolk syncytial nuclear migration during zebrafish epiboly. Fei Z, Bae K, Parent SE, Wan H, Goodwin K, Theisen U, Tanentzapf G, Bruce AEE., Development. 2019 Jan 2;146(1). doi: 10.1242/dev.169664.
  - Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration. Gerber T, Murawala P, Knapp D, Masselink W, Schuez M, Hermann S, Gac-Santel M, Nowoshilow S, Kageyama J, Khattak S, Currie JD, Camp JG, Tanaka EM, Treutlein B. Science. 2018 Oct 26;362(6413). doi: 10.1126/science.aaq0681.
  - Oxidative Stress Orchestrates Cell Polarity to Promote Embryonic Wound Healing. Hunter MV, Willoughby PM, Bruce AEE, Fernandez-Gonzalez R. Dev Cell. 2018 Nov 5;47(3):377-387.e4. doi: 10.1016/j.devcel.2018.10.013.
  - Collision of Expanding Actin Caps with Actomyosin Borders for Cortical Bending and Mitotic Rounding in a Syncytium. Zhang Y, Yu JC, Jiang T, Fernandez-Gonzalez R, Harris TJC. Dev Cell. 2018 Jun 4;45(5):551-564.e4. doi: 10.1016/j.devcel.2018.04.024.