Special Seminar – Principal Investigator Gregory Emery, Institute for Research in Immunology and Cancer

CSB Seminar

Principal Investigator Gregory Emery

Vesicular Trafficking and Cell Signalling Research Unit, Institute for Research in Immunology and Cancer
Associate Professor, Department of Pathology and Cell Biology, Faculty of Medicine, Université de MontréalInstitute for Research in Immunology and Cancer

“Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration”

Thursday, June 14, 2018
2:00-3:00 p.m. at RW 432
Host: Professor Rodrigo Fernandez-Gonzalez

Collective cell migration is a fundamental process involved in development, wound healing and metastasis. In the Drosophila ovary, border cells form a small cluster that migrates collectively through the egg chamber. To achieve directed motility, the border cell cluster must coordinate the formation of protrusions in their leader cell and contractility at the rear. The mechanism that restricts protrusions to leader cells requires the activity of the actin and plasma membrane linker Moesin. Herein, we show that the Ste20-like kinase Misshapen phosphorylates Moesin in vitro and in border cells. Depletion of Misshapen disrupts this protrusion restriction mechanism, thereby allowing other cells within the cluster to protrude as well. In addition, we show that Misshapen is critical to generate contractile forces both at the rear of the cluster and at the base of protrusions. Importantly, we find that in Misshapen-depleted clusters, expression of constitutively active forms of Moesin or Rok kinase restores protrusion restriction and contractility, respectively. Together, our results indicate that Misshapen is a master regulator of border cell migration as it coordinates two independent pathways that restrict protrusion formation to the leader cells and induces contractile forces.

Professor Peter McCourt named the Jack Dainty Distinguished Professor at the University of Toronto

Professor Peter McCourt has been named the Jack Dainty Distinguished Professor at the University of Toronto.

The purpose of the Distinguished Professor program is to advance and recognize individuals with highly distinguished accomplishments and those who display exceptional promise, who maintain an extraordinary level of activity in their research and scholarly work and have achieved pre-eminence in their field in line with the University’s stated objectives and emerging priorities.
You can read a snapshot of some of his accomplishments here:


Congratulations Professor McCourt on this most deserved recognition!