Christina Guzzo

faculty_img Academic Title: Assistant Professor

Campus: UTSC

CSB Appointment: Full

Primary Undergraduate Department:
Biological Sciences

Graduate Programs:
Cell & Systems Biology

Academic or Administrative Appointments:

Education:
Queen’s University B.Sc.H. 2007
Queen’s University Ph.D. 2012
National Institute of Allergy and Infectious Diseases Post-doctoral Fellowship NIH 2012-2017

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4
Canada

 

Contact Information
Office phone: 416-287-7436
Office: SY 264
Lab: SW 427
Lab phone:
Email: christina.guzzo@utoronto.ca
URL:

 

Research Areas

Microbiology
Pathology
Cell Biology
Molecular Biology

 

Research

Despite the extraordinary progress made over the past 30 years in our understanding of HIV pathogenesis and the development of increasingly effective therapeutic strategies to control the pandemic, AIDS remains one of the greatest scientific and public health challenges of our time. Future advances in the field depend on a deeper knowledge of the key molecular mechanisms underlying HIV-1 homing, tropism, transmission, and pathogenesis. My research is targeted at filling this gap by investigating the role of endogenous immune modulators impacting HIV-1 infection. The major aim of my research is to delineate molecular mechanisms underlying HIV-1 transmission and pathogenesis, with an end goal of using this knowledge to inform new approaches for HIV-1 prevention and treatment. My research program investigates the role of immune modulators produced by host cells in HIV-1 infection from two angles of approach; 1) soluble, anti-viral, immune factors (e.g. antiviral cytokines/chemokines), and 2) host proteins that get incorporated into HIV-1 virions (e.g. integrin alpha 4 beta 7). The aim of these studies is to identify new vulnerabilities on the virus that may lead to novel targets for therapy and prevention.

 

Publications