Christina Guzzo

faculty_img Academic Title: Assistant Professor

Campus: UTSC

CSB Appointment: Full

Primary Undergraduate Department:
Biological Sciences

Graduate Programs:
Cell & Systems Biology
Academic or Administrative Appointments:

Education:
Queen’s University B.Sc.H. 2007
Queen’s University Ph.D. 2012
National Institute of Allergy and Infectious Diseases Post-doctoral Fellowship NIH 2012-2017

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
1265 Military Trail
Scarborough, ON M1C 1A4
Canada

 

Contact Information
Office phone: 416-287-7436
Office: SY 264
Lab: SW 427
Lab phone:
Email: christina.guzzo@utoronto.ca
URL:

 

Research Areas

Microbiology
Pathology
Cell Biology
Molecular Biology

 

Research

Despite the extraordinary progress made over the past 30 years in our understanding of HIV pathogenesis and the development of increasingly effective therapeutic strategies to control the pandemic, AIDS remains one of the greatest scientific and public health challenges of our time. Future advances in the field depend on a deeper knowledge of the key molecular mechanisms underlying HIV-1 homing, tropism, transmission, and pathogenesis. My research is targeted at filling this gap by investigating the role of endogenous immune modulators impacting HIV-1 infection. The major aim of my research is to delineate molecular mechanisms underlying HIV-1 transmission and pathogenesis, with an end goal of using this knowledge to inform new approaches for HIV-1 prevention and treatment. My research program investigates the role of immune modulators produced by host cells in HIV-1 infection from two angles of approach; 1) soluble, anti-viral, immune factors (e.g. antiviral cytokines/chemokines), and 2) host proteins that get incorporated into HIV-1 virions (e.g. integrin alpha 4 beta 7). The aim of these studies is to identify new vulnerabilities on the virus that may lead to novel targets for therapy and prevention.

 

Publications

 


2017
2016
2015
2014
2013
2012
2011
2010
 

2017

Top

Corrigendum: Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. Liu Q, Acharya P, Dolan MA, Zhang P, Guzzo C, Lu J, Kwon A, Gururani D, Miao H, Bylund T, Chuang GY, Druz A, Zhou T, Rice WJ, Wigge C, Carragher B, Potter CS, Kwong PD, Lusso P. Nat Struct Mol Biol. 2017 Jun 6;24(6):553. doi: 10.1038/nsmb0617-553b.
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Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing. Guzzo C, Ichikawa D, Park C, Phillips D, Liu Q, Zhang P, Kwon A, Miao H, Lu J, Rehm C, Arthos J, Cicala C, Cohen MS, Fauci AS, Kehrl JH, Lusso P. Sci Immunol. 2017 May 12;2(11). pii: eaam7341. doi: 10.1126/sciimmunol.aam7341.
pubmed
Design of HIV Coreceptor Derived Peptides That Inhibit Viral Entry at Submicromolar Concentrations. Bobyk KD, Mandadapu SR, Lohith K, Guzzo C, Bhargava A, Lusso P, Bewley CA. Mol Pharm. 2017 Jul 13. doi: 10.1021/acs.molpharmaceut.7b00155. [Epub ahead of print]
pubmed
IL-27 enhances LPS-induced IL-1β in human monocytes and murine macrophages. Petes C, Wynick C, Guzzo C, Mehta D, Logan S, Banfield BW, Basta S, Cooper A, Gee K. J Leukoc Biol. 2017 Jul;102(1):83-94. doi: 10.1189/jlb.3A0316-098R. Epub 2017 Apr 4.
pubmed
Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. Liu Q, Acharya P, Dolan MA, Zhang P, Guzzo C, Lu J, Kwon A, Gururani D, Miao H, Bylund T, Chuang GY, Druz A, Zhou T, Rice WJ, Wigge C, Carragher B, Potter CS, Kwong PD, Lusso P. Nat Struct Mol Biol. 2017 Apr;24(4):370-378. doi: 10.1038/nsmb.3382. Epub 2017 Feb 20.
pubmed
 

2016

Top

Tyrosine-sulfated V2 peptides inhibit HIV-1 infection via coreceptor mimicry. Cimbro R, Peterson FC, Liu Q, Guzzo C, Zhang P, Miao H, Van Ryk D, Ambroggio X, Hurt DE, De Gioia L, Volkman BF, Dolan MA, Lusso P. EBioMedicine. 2016 Aug;10:45-54. doi: 10.1016/j.ebiom.2016.06.037. Epub 2016 Jun 26.
pubmed
 

2015

Top

Engineering Metamorphic Chemokine Lymphotactin/XCL1 into the GAG-Binding, HIV-Inhibitory Dimer Conformation. Fox JC, Tyler RC, Guzzo C, Tuinstra RL, Peterson FC, Lusso P, Volkman BF. ACS Chem Biol. 2015 Nov 20;10(11):2580-8. doi: 10.1021/acschembio.5b00542. Epub 2015 Sep 2.
pubmed
Structural Determinants for the Selective Anti-HIV-1 Activity of the All-β Alternative Conformer of XCL1. Guzzo C, Fox JC, Miao H, Volkman BF, Lusso P. J Virol. 2015 Sep;89(17):9061-7. doi: 10.1128/JVI.01285-15. Epub 2015 Jun 17.
pubmed
Characterization of HIV-1 entry inhibitors with broad activity against R5 and X4 viral strains. Sironi F, Malnati M, Mongelli N, Cozzi P, Guzzo C, Ghezzi S, Martínez-Romero C, García-Sastre A, Lusso P, Jabes D, Biswas P. J Transl Med. 2015 Apr 2;13:107. doi: 10.1186/s12967-015-0461-9.
pubmed
 

2014

Top

Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity. Cimbro R, Gallant TR, Dolan MA, Guzzo C, Zhang P, Lin Y, Miao H, Van Ryk D, Arthos J, Gorshkova I, Brown PH, Hurt DE, Lusso P. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3152-7. doi: 10.1073/pnas.1314718111. Epub 2014 Feb 3.
pubmed
 

2013

Top

The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1. Guzzo C, Fox J, Lin Y, Miao H, Cimbro R, Volkman BF, Fauci AS, Lusso P. PLoS Pathog. 2013;9(12):e1003852. doi: 10.1371/journal.ppat.1003852. Epub 2013 Dec 26.
pubmed
 

2012

Top

The TLR2 agonists lipoteichoic acid and Pam3CSK4 induce greater pro-inflammatory responses than inactivated Mycobacterium butyricum. Gambhir V, Yildiz C, Mulder R, Siddiqui S, Guzzo C, Szewczuk M, Gee K, Basta S. Cell Immunol. 2012 Nov;280(1):101-7. doi: 10.1016/j.cellimm.2012.12.001. Epub 2012 Dec 19.
pubmed
IL-27 increases BST-2 expression in human monocytes and T cells independently of type I IFN. Guzzo C, Jung M, Graveline A, Banfield BW, Gee K. Sci Rep. 2012;2:974. doi: 10.1038/srep00974. Epub 2012 Dec 13.
pubmed
IL-27-induced gene expression is downregulated in HIV-infected subjects. Guzzo C, Hopman WM, Che Mat NF, Wobeser W, Gee K. PLoS One. 2012;7(9):e45706. doi: 10.1371/journal.pone.0045706. Epub 2012 Sep 25.
pubmed
IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes. Guzzo C, Ayer A, Basta S, Banfield BW, Gee K. J Immunol. 2012 Jan 15;188(2):864-73. doi: 10.4049/jimmunol.1101912. Epub 2011 Dec 7.
pubmed
 

2011

Top

Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling. Abdulkhalek S, Amith SR, Franchuk SL, Jayanth P, Guo M, Finlay T, Gilmour A, Guzzo C, Gee K, Beyaert R, Szewczuk MR. J Biol Chem. 2011 Oct 21;286(42):36532-49. doi: 10.1074/jbc.M111.237578. Epub 2011 Aug 26.
pubmed
Interleukin-23-induced interleukin-23 receptor subunit expression is mediated by the Janus kinase/signal transducer and activation of transcription pathway in human CD4 T cells. Che Mat NF, Zhang X, Guzzo C, Gee K. J Interferon Cytokine Res. 2011 Apr;31(4):363-71. doi: 10.1089/jir.2010.0083. Epub 2010 Dec 7.
pubmed
 

2010

Top

Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo. Finlay TM, Abdulkhalek S, Gilmour A, Guzzo C, Jayanth P, Amith SR, Gee K, Beyaert R, Szewczuk MR. Glycoconj J. 2010 Aug;27(6):583-600. doi: 10.1007/s10719-010-9302-5. Epub 2010 Aug 10.
pubmed
Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes. Guzzo C, Che Mat NF, Gee K. J Biol Chem. 2010 Aug 6;285(32):24404-11. doi: 10.1074/jbc.M110.112599. Epub 2010 Jun 2.
pubmed