David Guttman

faculty_img Academic Title: Professor

Campus: St. George

CSB Appointment: Full

Primary Undergraduate Department:
Cell & Systems Biology

Graduate Programs:
Cell & Systems Biology
Genome Biology & Bioinformatics

Titles and Honors:
Canada Research Chair in Comparative Genomics

Academic or Administrative Appointments:
Associate Chair for Research
Director, Centre for the Analysis of Genome Evolution & Function

Education:
Ph.D. Stony Brook University 1994
B.Sc. Washington University in St. Louis 1987

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
25 Willcocks St.
Toronto, ON M5S 3B2
Canada
 

 

Contact Information
Office phone: 416-978-6865 
Office: ESC 4041 
Lab: ESC 4039 
Lab phone: 416-946-7121 
Email: david.guttman@utoronto.ca 
URL: http://labs.csb.utoronto.ca/guttman

 

Research Areas
Bioinformatics & Computational Biology
Comparative Genomics
Evolutionary Biology
Functional Genomics
Genetics
Microbiology
Pathology
Plant Biology

 

Research

The Guttman lab has two major foci. First, we are studying the evolution of host specificity and virulence in pathogenic bacteria. We are specifically interested in identifying the genetic determinants of host specificity, and determining what factors determine if a particular bacterial-host interaction is benign or results in disease. Our work will lead to a better understanding of where the genetic potential for virulence originates and how is it maintained in bacterial populations. Most of this work is done with the agriculturally important plant pathogen Pseudomonas syringae and the model plant Arabidopsis thaliana. Our second focus is on the structure, dynamics, and function of bacterial communities (microbiomes) associated with both humans and plants. We are specifically interested in understanding how polymicrobial communities influence the expression and course of disease. Microbiomes have been shown to dramatically influence immune development and disease resistance and progression. Most of this work is focused on cystic fibrosis, and plant resistance, although we also study a number of other human pathologies such as inflammatory bowel disease. We use a wide range of comparative, evolutionary and functional genomic approaches in the group. We have a particularly strong emphasis on using evolutionary and bioinformatic approaches to generate hypotheses that can then be functionally validated through traditional molecular and biochemical assays.

 

Publications

 

2016

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Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.Azad, M B, T Konya, R R Persaud, D S Guttman, R S Chari, C J Field, M R Sears, et al. 2015. BJOG : an international journal of obstetrics and gynaecology, no. 6 (September 28). doi:10.1111/1471-0528.13601.
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Evolution, genomics and epidemiology of Pseudomonas syringae: Challenges in Bacterial Molecular Plant Pathology.Baltrus, David A, Honour C McCann, and David S Guttman. 2016. Molecular plant pathology, no. 1 (November 25). doi:10.1111/mpp.12506.
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Prophages mediate defense against phage infection through diverse mechanisms.Bondy-Denomy, Joseph, Jason Qian, Edze R Westra, Angus Buckling, David S Guttman, Alan R Davidson, and Karen L Maxwell. 2016. The ISME journal, no. 12 (June 3). doi:10.1038/ismej.2016.79.
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High fecal IgA is associated with reduced Clostridium difficile colonization in infants.Bridgman, Sarah L, Tedd Konya, Meghan B Azad, David S Guttman, Malcolm R Sears, Allan B Becker, Stuart E Turvey, et al. 2016. Microbes and infection, no. 9 (May 24). doi:10.1016/j.micinf.2016.05.001.
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Oral Vancomycin Followed by Fecal Transplantation Versus Tapering Oral Vancomycin Treatment for Recurrent Clostridium difficile Infection: An Open-Label, Randomized Controlled Trial.Hota, Susy S, Valerie Sales, George Tomlinson, Mary Jane Salpeter, Allison McGeer, Bryan Coburn, David S Guttman, Donald E Low, and Susan M Poutanen. 2016. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (November 9). doi:ciw731.
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Image-Based Quantification of Plant Immunity and Disease.Laflamme, Bradley, Maggie Middleton, Timothy Lo, Darrell Desveaux, and David S Guttman. 2016. Molecular plant-microbe interactions : MPMI (December 20).
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Disentangling Interactions in the Microbiome: A Network Perspective. Layeghifard, Mehdi, David M Hwang, and David S Guttman. 2016. Trends in microbiology (December 1). doi:S0966-842X(16)30185-8.
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The HopF family of Pseudomonas syringae type III secreted effectors.Lo, Timothy, Noushin Koulena, Derek Seto, David S Guttman, and Darrell Desveaux. 2016. Molecular plant pathology (April 6). doi:10.1111/mpp.12412.
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Genomic screens identify a new phytobacterial microbe-associated molecular pattern and the cognate Arabidopsis receptor-like kinase that mediates its immune elicitation.Mott, G Adam, Shalabh Thakur, Elwira Smakowska, Pauline W Wang, Youssef Belkhadir, Darrell Desveaux, and David S Guttman. 2016. Genome biology (May 9). doi:10.1186/s13059-016-0955-7.
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Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways.Ryczko, Michael C, Judy Pawling, Rui Chen, Anas M Abdel Rahman, Kevin Yau, Julia K Copeland, Cunjie Zhang, et al. 2016. Scientific reports (March 14). doi:10.1038/srep23043.
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NKT Cell-Deficient Mice Harbor an Altered Microbiota That Fuels Intestinal Inflammation during Chemically Induced Colitis. Selvanantham, Thirumahal, Qiaochu Lin, Cynthia Xinyi Guo, Anuradha Surendra, Stephanie Fieve, Nichole K Escalante, David S Guttman, et al. 2016. Journal of immunology (Baltimore, Md. : 1950), no. 11 (October 31).
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A De-Novo Genome Analysis Pipeline (DeNoGAP) for large-scale comparative prokaryotic genomics studies.Thakur, Shalabh, and David S Guttman. 2016. BMC bioinformatics, no. 1 (June 30). doi:10.1186/s12859-016-1142-2.
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Phytopathogen Genome Announcement: Draft Genome Sequences of 62 Pseudomonas syringae Type and Pathotype Strains. Thakur, Shalabh, Bevan S Weir, and David S Guttman. 2016. Molecular plant-microbe interactions : MPMI, no. 4 (March 17). doi:10.1094/MPMI-01-16-0013-TA.
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Association of host genome with intestinal microbial composition in a large healthy cohort. Turpin, Williams, Osvaldo Espin-Garcia, Wei Xu, Mark S Silverberg, David Kevans, Michelle I Smith, David S Guttman, et al. 2016. Nature genetics, no. 11 (October 3). doi:10.1038/ng.3693.
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Chronic infection phenotypes of Pseudomonas aeruginosa are associated with failure of eradication in children with cystic fibrosis. Vidya, P, L Smith, T Beaudoin, Y C Yau, S Clark, B Coburn, D S Guttman, D M Hwang, and V Waters. 2016. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, no. 1.
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Gene Slider: sequence logo interactive data-visualization for education and research. Waese, Jamie, Asher Pasha, Ting Ting Wang, Anna van Weringh, David S Guttman, and Nicholas J Provart. 2016. Bioinformatics (Oxford, England), no. 23 (August 13).
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2015

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Genomic and Gene-Expression Comparisons among Phage-Resistant Type-IV Pilus Mutants of Pseudomonas syringae pathovar phaseolicola.Sistrom, Mark, Derek Park, Heath E O’Brien, Zheng Wang, David S Guttman, Jeffrey P Townsend, and Paul E Turner. 2015. PloS one, no. 12 (December 15). doi:10.1371/journal.pone.0144514.
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Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation. Kim, Sang Hu, Shawn T Clark, Anuradha Surendra, Julia K Copeland, Pauline W Wang, Ron Ammar, Cathy Collins, et al. 2015. PLoS pathogens, no. 11 (November 20). doi:10.1371/journal.ppat.1005308.
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Elevated Temperature Differentially Influences Effector-Triggered Immunity Outputs in Arabidopsis.Menna, Alexandra, Dang Nguyen, David S Guttman, and Darrell Desveaux. 2015. Frontiers in plant science (November 9). doi:10.3389/fpls.2015.00995.
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Chronic infection phenotypes of Pseudomonas aeruginosa are associated with failure of eradication in children with cystic fibrosis.Vidya P, Smith L, Beaudoin T, Yau YC, Clark S, Coburn B, Guttman DS, Hwang DM, Waters V.Eur. J. Clin. Microbiol. Infect. Dis. 2015 Oct;
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Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.Azad MB, Konya T, Persaud RR, Guttman DS, Chari RS, Field CJ, Sears MR, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL, .BJOG 2015 Sep;
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Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung.Diaz Caballero J, Clark ST, Coburn B, Zhang Y, Wang PW, Donaldson SL, Tullis DE, Yau YC, Waters VJ, Hwang DM, Guttman DS.MBio 2015;6(5):e00981-15
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Comparative genomic analysis of multiple strains of two unusual plant pathogens: Pseudomonas corrugata and Pseudomonas mediterranea.Trantas EA, Licciardello G, Almeida NF, Witek K, Strano CP, Duxbury Z, Ververidis F, Goumas DE, Jones JD, Guttman DS, Catara V, Sarris PF.Front Microbiol 2015;6:811
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Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis.Clark ST, Diaz Caballero J, Cheang M, Coburn B, Wang PW, Donaldson SL, Zhang Y, Liu M, Keshavjee S, Yau YC, Waters VJ, Elizabeth Tullis D, Guttman DS, Hwang DM.Sci Rep 2015;5:10932
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The human microbiome.Coburn B, Guttman DS.CMAJ 2015 Aug;187(11):825
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Lung microbiota across age and disease stage in cystic fibrosis.Coburn B, Wang PW, Diaz Caballero J, Clark ST, Brahma V, Donaldson S, Zhang Y, Surendra A, Gong Y, Elizabeth Tullis D, Yau YC, Waters VJ, Hwang DM, Guttman DS.Sci Rep 2015;5:10241
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Regulation of obesity-related insulin resistance with gut anti-inflammatory agents.Luck H, Tsai S, Chung J, Clemente-Casares X, Ghazarian M, Revelo XS, Lei H, Luk CT, Shi SY, Surendra A, Copeland JK, Ahn J, Prescott D, Rasmussen BA, Chng MH, Engleman EG, Girardin SE, Lam TK, Croitoru K, Dunn S, Philpott DJ, Guttman DS, Woo M, Winer S, Winer DA.Cell Metab. 2015 Apr;21(4):527-42
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Seasonal Community Succession of the Phyllosphere Microbiome.Copeland JK, Yuan L, Layeghifard M, Wang PW, Guttman DS.Mol. Plant Microbe Interact. 2015 Mar;28(3):274-285
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Infant gut microbiota and food sensitization: associations in the first year of life.Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, HayGlass KT, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL, .Clin. Exp. Allergy 2015 Jan;
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2014

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Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis.Lewis JD, Wilton M, Mott GA, Lu W, Hassan JA, Guttman DS, Desveaux D.PLoS ONE 2014;9(12):e116152
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Proteomics of effector-triggered immunity (ETI) in plants.Hurley B, Subramaniam R, Guttman DS, Desveaux D.Virulence 2014;5(7):752-60
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Peptides and small molecules of the plant-pathogen apoplastic arena.Mott GA, Middleton MA, Desveaux D, Guttman DS.Front Plant Sci 2014;5:677
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The Pseudomonas syringae Type III Effector HopF2 Suppresses Arabidopsis Stomatal Immunity.Hurley B, Lee D, Mott A, Wilton M, Liu J, Liu YC, Angers S, Coaker G, Guttman DS, Desveaux D.PLoS ONE 2014;9(12):e114921
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Opinion: Conservation and stewardship of the human microbiome.O’Doherty KC, Neufeld JD, Brinkman FS, Gardner H, Guttman DS, Beiko RG.Proc. Natl. Acad. Sci. U.S.A. 2014 Oct;111(40):14312-3
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Proteomics of effector-triggered immunity (ETI) in plants.Hurley B, Subramaniam R, Guttman DS, Desveaux D.Virulence 2014 Sep;5(7)
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Microbial genome-enabled insights into plant-microorganism interactions.Guttman D, McHardy AC, Schulze-Lefert P.Nat. Rev. Genet. 2014 Sep;
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Gut microbial metabolism drives transformation of msh2-deficient colon epithelial cells.Belcheva A, Irrazabal T, Robertson SJ, Streutker C, Maughan H, Rubino S, Moriyama EH, Copeland JK, Kumar S, Green B, Geddes K, Pezo RC, Navarre WW, Milosevic M, Wilson BC, Girardin SE, Wolever TM, Edelmann W, Guttman DS, Philpott DJ, Martin A.Cell 2014 Jul;158(2):288-99
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Associations between bacterial communities of house dust and infant gut.Konya T, Koster B, Maughan H, Escobar M, Azad MB, Guttman DS, Sears MR, Becker AB, Brook JR, Takaro TK, Kozyrskyj AL, Scott JA, .Environ. Res. 2014 May;131:25-30
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HopZ4 from Pseudomonas syringae, a Member of the HopZ Type III Effector Family from the YopJ Superfamily, Inhibits the Proteasome in Plants.Ustün S, König P, Guttman DS, Börnke F.Mol. Plant Microbe Interact. 2014 Jul;27(7):611-23
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The rise of the undead: Pseudokinases as mediators of effector-triggered immunity.Lewis JD, Lo T, Bastedo P, Guttman DS, Desveaux D.Plant Signal Behav 2014 Jan;9(1)
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Next-generation mapping of genetic mutations using bulk population sequencing.Austin RS, Chatfield SP, Desveaux D, Guttman DS.Methods Mol. Biol. 2014;1062:301-15
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2013

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The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a.Lewis JD, Lee AH, Hassan JA, Wan J, Hurley B, Jhingree JR, Wang PW, Lo T, Youn JY, Guttman DS, Desveaux D.Proc. Natl. Acad. Sci. U.S.A. 2013 Nov;110(46):18722-7
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Characterization of the gut-associated microbiome in inflammatory pouch complications following ileal pouch-anal anastomosis.Tyler AD, Knox N, Kabakchiev B, Milgrom R, Kirsch R, Cohen Z, McLeod RS, Guttman DS, Krause DO, Silverberg MS.PLoS ONE 2013;8(9):e66934
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Genomic analysis of the Kiwifruit pathogen Pseudomonas syringae pv. actinidiae provides insight into the origins of an emergent plant disease.McCann HC, Rikkerink EH, Bertels F, Fiers M, Lu A, Rees-George J, Andersen MT, Gleave AP, Haubold B, Wohlers MW, Guttman DS, Wang PW, Straub C, Vanneste JL, Vanneste J, Rainey PB, Templeton MD.PLoS Pathog. 2013;9(7):e1003503
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Neutral genomic microevolution of a recently emerged pathogen, Salmonella enterica serovar Agona.Zhou Z, McCann A, Litrup E, Murphy R, Cormican M, Fanning S, Brown D, Guttman DS, Brisse S, Achtman M.PLoS Genet. 2013 Apr;9(4):e1003471
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Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity.Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Sears MR, Becker AB, Scott JA, Kozyrskyj AL.Allergy Asthma Clin Immunol 2013;9(1):15
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Phytopathogen type III effectors as probes of biological systems.Lee AH, Middleton MA, Guttman DS, Desveaux D.Microb Biotechnol 2013 May;6(3):230-40
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Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months.Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, .CMAJ 2013 Mar;185(5):385-94
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Gut microbiota diversity and atopic disease: does breast-feeding play a role?.Azad MB, Becker AB, Guttman DS, Sears MR, Scott JA, Kozyrskyj AL, .J. Allergy Clin. Immunol. 2013 Jan;131(1):247-8
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2012

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Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole.Schreiber KJ, Austin RS, Gong Y, Zhang J, Fung P, Wang PW, Guttman DS, Desveaux D.BMC Plant Biol. 2012;12:226
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Analysis of the cystic fibrosis lung microbiota via serial Illumina sequencing of bacterial 16S rRNA hypervariable regions.Maughan H, Wang PW, Diaz Caballero J, Fung P, Gong Y, Donaldson SL, Yuan L, Keshavjee S, Zhang Y, Yau YC, Waters VJ, Tullis DE, Hwang DM, Guttman DS.PLoS ONE 2012;7(10):e45791
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Comparison of three typing methods for Pseudomonas aeruginosa isolates from patients with cystic fibrosis.Waters V, Zlosnik JE, Yau YC, Speert DP, Aaron SD, Guttman DS.Eur. J. Clin. Microbiol. Infect. Dis. 2012 Dec;31(12):3341-50
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Extensive remodeling of the Pseudomonas syringae pv. avellanae type III secretome associated with two independent host shifts onto hazelnut.O’Brien HE, Thakur S, Gong Y, Fung P, Zhang J, Yuan L, Wang PW, Yong C, Scortichini M, Guttman DS.BMC Microbiol. 2012;12:141
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Pseudomonas syringae pv. actinidiae (PSA) isolates from recent bacterial canker of kiwifruit outbreaks belong to the same genetic lineage.Mazzaglia A, Studholme DJ, Taratufolo MC, Cai R, Almeida NF, Goodman T, Guttman DS, Vinatzer BA, Balestra GM.PLoS ONE 2012;7(5):e36518
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Pulmonary bacterial communities in surgically resected noncystic fibrosis bronchiectasis lungs are similar to those in cystic fibrosis.Maughan H, Cunningham KS, Wang PW, Zhang Y, Cypel M, Chaparro C, Tullis DE, Waddell TK, Keshavjee S, Liu M, Guttman DS, Hwang DM.Pulm Med 2012;2012:746358
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Identification of innate immunity elicitors using molecular signatures of natural selection.McCann HC, Nahal H, Thakur S, Guttman DS.Proc. Natl. Acad. Sci. U.S.A. 2012 Mar;109(11):4215-20
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A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion.Lee AH, Hurley B, Felsensteiner C, Yea C, Ckurshumova W, Bartetzko V, Wang PW, Quach V, Lewis JD, Liu YC, Börnke F, Angers S, Wilde A, Guttman DS, Desveaux D.PLoS Pathog. 2012 Feb;8(2):e1002523
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Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis.Lee SJ, Lee J, Li KK, Holland D, Maughan H, Guttman DS, Yusta B, Drucker DJ.Endocrinology 2012 Mar;153(3):1141-51
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Quantitative Interactor Screening with next-generation Sequencing (QIS-Seq) identifies Arabidopsis thaliana MLO2 as a target of the Pseudomonas syringae type III effector HopZ2.Lewis JD, Wan J, Ford R, Gong Y, Fung P, Nahal H, Wang PW, Desveaux D, Guttman DS.BMC Genomics 2012;13:8
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E622, a miniature, virulence-associated mobile element.Stavrinides J, Kirzinger MW, Beasley FC, Guttman DS.J. Bacteriol. 2012 Jan;194(2):509-17
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HopAS1 recognition significantly contributes to Arabidopsis nonhost resistance to Pseudomonas syringae pathogens.Sohn KH, Saucet SB, Clarke CR, Vinatzer BA, O’Brien HE, Guttman DS, Jones JD.New Phytol. 2012 Jan;193(1):58-66
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2011

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Use of low-coverage, large-insert, short-read data for rapid and accurate generation of enhanced-quality draft Pseudomonas genome sequences.O’Brien HE, Gong Y, Fung P, Wang PW, Guttman DS.PLoS ONE 2011;6(11):e27199
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Tri6 is a global transcription regulator in the phytopathogen Fusarium graminearum.Nasmith CG, Walkowiak S, Wang L, Leung WW, Gong Y, Johnston A, Harris LJ, Guttman DS, Subramaniam R.PLoS Pathog. 2011 Sep;7(9):e1002266
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The YopJ superfamily in plant-associated bacteria.Lewis JD, Lee A, Ma W, Zhou H, Guttman DS, Desveaux D.Mol. Plant Pathol. 2011 Dec;12(9):928-37
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Evolution of plant pathogenesis in Pseudomonas syringae: a genomics perspective.O’Brien HE, Thakur S, Guttman DS.Annu Rev Phytopathol 2011;49:269-89
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Next-generation mapping of Arabidopsis genes.Austin RS, Vidaurre D, Stamatiou G, Breit R, Provart NJ, Bonetta D, Zhang J, Fung P, Gong Y, Wang PW, McCourt P, Guttman DS.Plant J. 2011 Aug;67(4):715-25
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Transcriptomic responses of the softwood-degrading white-rot fungus Phanerochaete carnosa during growth on coniferous and deciduous wood.MacDonald J, Doering M, Canam T, Gong Y, Guttman DS, Campbell MM, Master ER.Appl. Environ. Microbiol. 2011 May;77(10):3211-8
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Next-generation genomics of Pseudomonas syringae.O’Brien HE, Desveaux D, Guttman DS.Curr. Opin. Microbiol. 2011 Feb;14(1):24-30
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2010

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Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populations.Anderson JB, Funt J, Thompson DA, Prabhu S, Socha A, Sirjusingh C, Dettman JR, Parreiras L, Guttman DS, Regev A, Kohn LM.Curr. Biol. 2010 Aug;20(15):1383-8
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Allele-specific virulence attenuation of the Pseudomonas syringae HopZ1a type III effector via the Arabidopsis ZAR1 resistance protein.Lewis JD, Wu R, Guttman DS, Desveaux D.PLoS Genet. 2010 Apr;6(4):e1000894
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PAMDB, a multilocus sequence typing and analysis database and website for plant-associated microbes.Almeida NF, Yan S, Cai R, Clarke CR, Morris CE, Schaad NW, Schuenzel EL, Lacy GH, Sun X, Jones JB, Castillo JA, Bull CT, Leman S, Guttman DS, Setubal JC, Vinatzer BA.Phytopathology 2010 Mar;100(3):208-15
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Pseudomonas syringae strains naturally lacking the classical P. syringae hrp/hrc Locus are common leaf colonizers equipped with an atypical type III secretion system.Clarke CR, Cai R, Studholme DJ, Guttman DS, Vinatzer BA.Mol. Plant Microbe Interact. 2010 Feb;23(2):198-210
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2009

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Bacterial evolution: dynamic genomes and the power of transformation.Guttman DS.Curr. Biol. 2009 Sep;19(18):R857-9
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The targeting of plant cellular systems by injected type III effector proteins.Lewis JD, Guttman DS, Desveaux D.Semin. Cell Dev. Biol. 2009 Dec;20(9):1055-63
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Using a commercial DiversiLab semiautomated repetitive sequence-based PCR typing technique for identification of Escherichia coli clone ST131 producing CTX-M-15.Pitout JD, Campbell L, Church DL, Wang PW, Guttman DS, Gregson DB.J. Clin. Microbiol. 2009 Apr;47(4):1212-5
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Allelic variants of the Pseudomonas syringae type III effector HopZ1 are differentially recognized by plant resistance systems.Zhou H, Morgan RL, Guttman DS, Ma W.Mol. Plant Microbe Interact. 2009 Feb;22(2):176-89
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2008

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A phylogenomic analysis of the shikimate dehydrogenases reveals broadscale functional diversification and identifies one functionally distinct subclass.Singh S, Stavrinides J, Christendat D, Guttman DS.Mol. Biol. Evol. 2008 Oct;25(10):2221-32
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Evolution of prokaryotic and eukaryotic virulence effectors.Ma W, Guttman DS.Curr. Opin. Plant Biol. 2008 Aug;11(4):412-9
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New and sensitive assay for determining Pseudomonas aeruginosa metallo-beta-lactamase resistance to imipenem.Tan J, Pitout JD, Guttman DS.J. Clin. Microbiol. 2008 May;46(5):1870-2
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The HopZ family of Pseudomonas syringae type III effectors require myristoylation for virulence and avirulence functions in Arabidopsis thaliana.Lewis JD, Abada W, Ma W, Guttman DS, Desveaux D.J. Bacteriol. 2008 Apr;190(8):2880-91
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Evolution of the type III secretion system and its effectors in plant-microbe interactions.McCann HC, Guttman DS.New Phytol. 2008;177(1):33-47
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Host-pathogen interplay and the evolution of bacterial effectors.Stavrinides J, McCann HC, Guttman DS.Cell. Microbiol. 2008 Feb;10(2):285-92
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2007

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Convergent evolution of phytopathogenic pseudomonads onto hazelnut.Wang PW, Morgan RL, Scortichini M, Guttman DS.Microbiology (Reading, Engl.) 2007 Jul;153(Pt 7):2067-73
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2006

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Type III effector diversification via both pathoadaptation and horizontal transfer in response to a coevolutionary arms race.Ma W, Dong FF, Stavrinides J, Guttman DS.PLoS Genet. 2006 Dec;2(12):e209
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Bioinformatics-enabled identification of the HrpL regulon and type III secretion system effector proteins of Pseudomonas syringae pv. phaseolicola 1448A.Vencato M, Tian F, Alfano JR, Buell CR, Cartinhour S, DeClerck GA, Guttman DS, Stavrinides J, Joardar V, Lindeberg M, Bronstein PA, Mansfield JW, Myers CR, Collmer A, Schneider DJ.Mol. Plant Microbe Interact. 2006 Nov;19(11):1193-206
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Terminal reassortment drives the quantum evolution of type III effectors in bacterial pathogens.Stavrinides J, Ma W, Guttman DS.PLoS Pathog. 2006 Oct;2(10):e104
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Comparative genomics of host-specific virulence in Pseudomonas syringae.Sarkar SF, Gordon JS, Martin GB, Guttman DS.Genetics 2006 Oct;174(2):1041-56
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Diversifying selection drives the evolution of the type III secretion system pilus of Pseudomonas syringae.Guttman DS, Gropp SJ, Morgan RL, Wang PW.Mol. Biol. Evol. 2006 Dec;23(12):2342-54
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2005

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Phylogenetic characterization of virulence and resistance phenotypes of Pseudomonas syringae.Hwang MS, Morgan RL, Sarkar SF, Wang PW, Guttman DS.Appl. Environ. Microbiol. 2005 Sep;71(9):5182-91
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Proposed guidelines for a unified nomenclature and phylogenetic analysis of type III Hop effector proteins in the plant pathogen Pseudomonas syringae.Lindeberg M, Stavrinides J, Chang JH, Alfano JR, Collmer A, Dangl JL, Greenberg JT, Mansfield JW, Guttman DS.Mol. Plant Microbe Interact. 2005 Apr;18(4):275-82
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2004

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The PCR amplification and characterization of entire Pseudomonas syringae hrp/hrc clusters.Gropp SJ, Guttman DS.Mol. Plant Pathol. 2004 Mar;5(2):137-40
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Diverse evolutionary mechanisms shape the type III effector virulence factor repertoire in the plant pathogen Pseudomonas syringae.Rohmer L, Guttman DS, Dangl JL.Genetics 2004 Jul;167(3):1341-60
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Nucleotide sequence and evolution of the five-plasmid complement of the phytopathogen Pseudomonas syringae pv. maculicola ES4326.Stavrinides J, Guttman DS.J. Bacteriol. 2004 Aug;186(15):5101-15
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Evolution of the core genome of Pseudomonas syringae, a highly clonal, endemic plant pathogen.Sarkar SF, Guttman DS.Appl. Environ. Microbiol. 2004 Apr;70(4):1999-2012
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Plants as models for the study of human pathogenesis.Guttman DS.Biotechnol. Adv. 2004 May;22(5):363-82
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Complete sequence and evolutionary genomic analysis of the Pseudomonas aeruginosa transposable bacteriophage D3112.Wang PW, Chu L, Guttman DS.J. Bacteriol. 2004 Jan;186(2):400-10
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Mosaic evolution of the severe acute respiratory syndrome coronavirus.Stavrinides J, Guttman DS.J. Virol. 2004 Jan;78(1):76-82
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2002

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A functional screen for the type III (Hrp) secretome of the plant pathogen Pseudomonas syringae.Guttman DS, Vinatzer BA, Sarkar SF, Ranall MV, Kettler G, Greenberg JT.Science 2002 Mar;295(5560):1722-6
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