David Lovejoy

faculty_img Academic Title: Professor

Campus: St. George

CSB Appointment: Full

Primary Undergraduate Department:
Cell & Systems Biology

Graduate Programs:
Cell & Systems Biology
Chemical & Physical Sciences

Titles and Honors:


Academic or Administrative Appointments:
Chair, University Animal Care Committee

Education:
Ph.D. University of Victoria
B.Sc. University of Alberta

 

Mailing Address
Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
Canada
 

 

Contact Information
Office phone: 416-946-7259 
Office: RW 305B 
Lab: RW 304 / 305 
Lab phone: 416-978-2483 
Email: david.lovejoy@utoronto.ca 
URL:

 

Research Areas
Animal Biology
Biotechnology
Cell Biology
Neurobiology
Physiology

 

Research

Our research program is focused on the actions of three families of peptide hormones that encompass metabolism, stress and reproduction. These include 1) teneurin C-terminal associated peptide family; 2) Corticotropin-releasing hormone family, and 3) gonadotropin releasing hormone family. Our interest is how paralogous expansion of stress and metabolism based peptides act to regulate reproduction, growth and behaviour. Current studies utilize mammal, fish and tunicate models to provide and understanding how these systems evolve in vertebrates. Other studies are aimed at developing new approaches for the treatment of human stress associated pathology in the area of neurological, metabolic and fertility disorders.

 

Publications

2014

Top
Repeated intravenous administrations of teneurin-C terminal associated peptide (TCAP)-1 attenuates reinstatement of cocaine seeking by corticotropin-releasing factor (CRF) in rats.Erb S, McPhee M, Brown ZJ, Kupferschmidt DA, Song L, Lovejoy DA.Behav. Brain Res. 2014 Aug;269:1-5
pubmed
Molecular evolution of GPCRs: CRH/CRH receptors.Lovejoy DA, Chang BS, Lovejoy NR, del Castillo J.J. Mol. Endocrinol. 2014 Jun;52(3):T43-60
pubmed
C-terminal region of teneurin-1 co-localizes with the dystroglycan complex in adult mouse testes and regulates testicular size and testosterone production.Chand D, Colacci M, Dixon K, Kollara A, Brown TJ, Lovejoy DA.Histochem. Cell Biol. 2014 Feb;141(2):191-211
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2013

Top
Appetite-suppressing effects and interactions of centrally administered corticotropin-releasing factor, urotensin I and serotonin in rainbow trout (Oncorhynchus mykiss).Ortega VA, Lovejoy DA, Bernier NJ.Front Neurosci 2013;7:196
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Evolution and phylogeny of the corticotropin-releasing factor (CRF) family of peptides: expansion and specialization in the vertebrates.Lovejoy DA, de Lannoy L.J. Chem. Neuroanat. 2013 Dec;54:50-6
pubmed
Teneurin C-terminal associated peptides (TCAP): modulators of corticotropin-releasing factor (CRF) physiology and behavior.Chen Y, Xu M, De Almeida R, Lovejoy DA.Front Neurosci 2013;7:166
pubmed
Systems approaches to genomic and epigenetic inter-regulation of peptide hormones in stress and reproduction.Lovejoy DA, Barsyte-Lovejoy D.Prog. Biophys. Mol. Biol. 2013 Dec;113(3):375-86
pubmed
Origin of chordate peptides by horizontal protozoan gene transfer in early metazoans and protists: evolution of the teneurin C-terminal associated peptides (TCAP).Chand D, de Lannoy L, Tucker R, Lovejoy DA.Gen. Comp. Endocrinol. 2013 Jul;188:144-50
pubmed
C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells.Chand D, Casatti CA, de Lannoy L, Song L, Kollara A, Barsyte-Lovejoy D, Brown TJ, Lovejoy DA.Mol. Cell. Neurosci. 2013 Jan;52:38-50
pubmed

2012

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Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells.Ng T, Chand D, Song L, Al Chawaf A, Watson JD, Boutros PC, Belsham DD, Lovejoy DA.Regul. Pept. 2012 Feb;174(1-3):79-89
pubmed
Modulation of neuroplastic changes and corticotropin-releasing factor-associated behavior by a phylogenetically ancient and conserved peptide family.Tan LA, Chand D, De Almeida R, Xu M, De Lannoy L, Lovejoy DA.Gen. Comp. Endocrinol. 2012 May;176(3):309-13
pubmed

2011

Top
Interfacial behavior of immortalized hypothalamic mouse neurons detected by acoustic wave propagation.Cheung S, Fick LJ, Belsham DD, Lovejoy DA, Thompson M.Analyst 2011 Nov;136(21):4412-21
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Teneurin C-terminal associated peptide (TCAP)-1 modulates dendritic morphology in hippocampal neurons and decreases anxiety-like behaviors in rats.Tan LA, Al Chawaf A, Vaccarino FJ, Boutros PC, Lovejoy DA.Physiol. Behav. 2011 Aug;104(2):199-204
pubmed
Stress and reproduction: controversies and challenges.Chand D, Lovejoy DA.Gen. Comp. Endocrinol. 2011 May;171(3):253-7
pubmed
Identification of members of the gonadotropin-releasing hormone (GnRH), corticotropin-releasing factor (CRF) families in the genome of the holocephalan, Callorhinchus milii (elephant shark).Nock TG, Chand D, Lovejoy DA.Gen. Comp. Endocrinol. 2011 Apr;171(2):237-44
pubmed
Teneurin C-terminal associated peptide-1 blocks the effects of corticotropin-releasing factor on reinstatement of cocaine seeking and on cocaine-induced behavioural sensitization.Kupferschmidt DA, Lovejoy DA, Rotzinger S, Erb S.Br. J. Pharmacol. 2011 Feb;162(3):574-83
pubmed

2010

Top
Behavioral effects of neuropeptides in rodent models of depression and anxiety.Rotzinger S, Lovejoy DA, Tan LA.Peptides 2010 Apr;31(4):736-56
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Characterization of a corticotropin-releasing factor (CRF)/diuretic hormone-like peptide from tunicates: insight into the origins of the vertebrate CRF family.Lovejoy DA, Barsyte-Lovejoy D.Gen. Comp. Endocrinol. 2010 Jan;165(2):330-6
pubmed

2009

Top
Evolution of complementary peptide systems: teneurin C-terminal-associated peptides and corticotropin-releasing factor superfamilies.Lovejoy DA, Rotzinger S, Barsyte-Lovejoy D.Ann. N. Y. Acad. Sci. 2009 Apr;1163:215-20
pubmed
Teneurin C-terminal associated peptide (TCAP)-1 attenuates corticotropin-releasing factor (CRF)-induced c-Fos expression in the limbic system and modulates anxiety behavior in male Wistar rats.Tan LA, Xu K, Vaccarino FJ, Lovejoy DA, Rotzinger S.Behav. Brain Res. 2009 Jul;201(1):198-206
pubmed
Structural evolution of urotensin-I: reflections of life before corticotropin releasing factor.Lovejoy DA.Gen. Comp. Endocrinol. 2009 Oct;164(1):15-9
pubmed

2008

Top
Repeated intracerebral teneurin C-terminal associated peptide (TCAP)-1 injections produce enduring changes in behavioral responses to corticotropin-releasing factor (CRF) in rat models of anxiety.Tan LA, Xu K, Vaccarino FJ, Lovejoy DA, Rotzinger S.Behav. Brain Res. 2008 Mar;188(1):195-200
pubmed

2007

Top
Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypothalamic cells.Trubiani G, Al Chawaf A, Belsham DD, Barsyte-Lovejoy D, Lovejoy DA.Brain Res. 2007 Oct;1176:27-36
pubmed
Corticotropin-releasing factor (CRF)-induced behaviors are modulated by intravenous administration of teneurin C-terminal associated peptide-1 (TCAP-1).Al Chawaf A, Xu K, Tan L, Vaccarino FJ, Lovejoy DA, Rotzinger S.Peptides 2007 Jul;28(7):1406-15
pubmed

2006

Top
Teneurin C-terminal associated peptides: an enigmatic family of neuropeptides with structural similarity to the corticotropin-releasing factor and calcitonin families of peptides.Lovejoy DA, Al Chawaf A, Cadinouche MZ.Gen. Comp. Endocrinol. 2006 Sep;148(3):299-305
pubmed
Phylogeny of the corticotropin-releasing factor family of peptides in the metazoa.Lovejoy DA, Jahan S.Gen. Comp. Endocrinol. 2006 Mar;146(1):1-8
pubmed

2005

Top
Gonadotropin-releasing hormone: gene evolution, expression, and regulation.Belsham DD, Lovejoy DA.Vitam. Horm. 2005;71:59-94
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Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity.Wang L, Rotzinger S, Al Chawaf A, Elias CF, Barsyte-Lovejoy D, Qian X, Wang NC, De Cristofaro A, Belsham D, Bittencourt JC, Vaccarino F, Lovejoy DA.Brain Res. Mol. Brain Res. 2005 Feb;133(2):253-65
pubmed

2004

Top
Cloning and characterization of teneurin C-terminus associated peptide (TCAP)-3 from the hypothalamus of an adult rainbow trout (Oncorhynchus mykiss).Qian X, Barsyte-Lovejoy D, Wang L, Chewpoy B, Gautam N, Al Chawaf A, Lovejoy DA.Gen. Comp. Endocrinol. 2004 Jun;137(2):205-16
pubmed

2003

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Urocortin in the central nervous system of a primate (Cebus apella): sequencing, immunohistochemical, and hybridization histochemical characterization.Vasconcelos LA, Donaldson C, Sita LV, Casatti CA, Lotfi CF, Wang L, Cadinouche MZ, Frigo L, Elias CF, Lovejoy DA, Bittencourt JC.J. Comp. Neurol. 2003 Aug;463(2):157-75
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